Visualizing the ribonucleoprotein content of single bunyavirus virions reveals more efficient genome packaging in the arthropod host

Autor: Erick Bermúdez-Méndez, Eugene A. Katrukha, Cindy M. Spruit, Jeroen Kortekaas, Paul J. Wichgers Schreur

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Bermúdez-Méndez et al. describe a FISH-immunofluorescence method that allows simultaneous visualization of bunyavirus genome segments and virions at single-molecule resolution. They show that the packaging of bunyavirus genome segments into virions

Externí odkaz: https://doaj.org/article/dbfc585081a74283ac54d99eb9b8f688

Multimeric single-domain antibody complexes protect against bunyavirus infections

Autor: Paul J Wichgers Schreur, Sandra van de Water, Michiel Harmsen, Erick Bermúdez-Méndez, Dubravka Drabek, Frank Grosveld, Kerstin Wernike, Martin Beer, Andrea Aebischer, Olalekan Daramola, Sara Rodriguez Conde, Karen Brennan, Dorota Kozub, Maiken Søndergaard Kristiansen, Kieran K Mistry, Ziyan Deng, Jan Hellert, Pablo Guardado-Calvo, Félix A Rey, Lucien van Keulen, Jeroen Kortekaas

Publikováno v: eLife, Vol 9 (2020)

The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist. Here, we describe a br

Externí odkaz: https://doaj.org/article/77e72f756264423fbde716e30e5a2df1

Innovative Immunization Strategies for Antivenom Development

Autor: Erick Bermúdez-Méndez, Albert Fuglsang-Madsen, Sofie Føns, Bruno Lomonte, José María Gutiérrez, Andreas Hougaard Laustsen

Publikováno v: Toxins, Vol 10, Iss 11, p 452 (2018)

Snakes, scorpions, and spiders are venomous animals that pose a threat to human health, and severe envenomings from the bites or stings of these animals must be treated with antivenom. Current antivenoms are based on plasma-derived immunoglobulins or

Externí odkaz: https://doaj.org/article/8ad3ab1b04d644e48406b4d83b43c9eb

Incomplete bunyavirus particles can cooperatively support virus infection and spread

Autor: Erick Bermúdez-Méndez, Kirsten F. Bronsvoort, Mark P. Zwart, Sandra van de Water, Ingrid Cárdenas-Rey, Rianka P. M. Vloet, Constantianus J. M. Koenraadt, Gorben P. Pijlman, Jeroen Kortekaas, Paul J. Wichgers Schreur

Publikováno v: PLoS Biology. Public Library of Science
PloS Biology, 20(11)
PloS Biology 20 (2022) 11

Bunyaviruses lack a specific mechanism to ensure the incorporation of a complete set of genome segments into each virion, explaining the generation of incomplete virus particles lacking one or more genome segments. Such incomplete virus particles, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b723b3865b4f5b17e5d54d7d62287c2
https://doi.org/10.1371/journal.pbio.3001870

Multimeric single-domain antibody complexes protect against bunyavirus infections

Autor: Frank Grosveld, Sara Rodriguez Conde, Paul J. Wichgers Schreur, Dorota Kozub, Jan Hellert, Kieran K Mistry, Erick Bermúdez-Méndez, Martin Beer, Pablo Guardado-Calvo, Félix A. Rey, Karen Brennan, Ziyan Deng, Michiel M. Harmsen, Olalekan Daramola, Sandra G. P. van de Water, Jeroen Kortekaas, Dubravka Drabek, Maiken Søndergaard Kristiansen, Andrea Aebischer, Lucien van Keulen, Kerstin Wernike

Publikováno v: eLife
eLife, eLife Sciences Publication, 2020, 9, pp.e52716. ⟨10.7554/eLife.52716⟩
eLife, 9:e52716. eLife Sciences Publications
eLife, 2020, 9, pp.e52716. ⟨10.7554/eLife.52716⟩
eLife, Vol 9 (2020)
eLife 9 (2020)
eLife, 9

International audience; The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa19d5508677dc13a105be694ea4493
https://hal-pasteur.archives-ouvertes.fr/pasteur-03207969/file/elife-52716-v1.pdf