Výsledky vyhledávání - "Erich Oberholzer"

Akademický článek

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition

Autor: D. Sean Froese, Jolanta Kopec, Elzbieta Rembeza, Gustavo Arruda Bezerra, Anselm Erich Oberholzer, Terttu Suormala, Seraina Lutz, Rod Chalk, Oktawia Borkowska, Matthias R. Baumgartner, Wyatt W. Yue

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

The human enzyme MTHFR links the folate and methionine cycles, which are essential for the biosynthesis of nucleotides and proteins. Here, the authors present the crystal structure and biochemical analysis of human MTHFR, providing molecular insights

Externí odkaz: https://doaj.org/article/81b79808dd01406c825d1806af1a047c

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Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition

Autor: Elzbieta Rembeza, D. Sean Froese, Terttu Suormala, Anselm Erich Oberholzer, Oktawia Borkowska, Wyatt W. Yue, Jolanta Kopec, Gustavo Arruda Bezerra, Rod Chalk, Seraina Lutz, Matthias R. Baumgartner

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications

The folate and methionine cycles are crucial for biosynthesis of lipids, nucleotides and proteins, and production of the methyl donor S-adenosylmethionine (SAM). 5,10-methylenetetrahydrofolate reductase (MTHFR) represents a key regulatory connection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c668c6b07c00337b17f534542d0bce
http://link.springer.com/article/10.1038/s41467-018-04735-2

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Quality of life in adult patients with epilepsy and their family members

Autor: Günther Krämer, Armanda Bonomo, Priska Eggenschwiler, Sabina Jaggi, Hannele Hediger, Romy Mahrer-Imhof, Erich Oberholzer

Publikováno v: Seizure : the journal of the British Epilepsy Association

Purpose Epilepsy is not only a neurological disorder but may also have negative psychosocial consequences on people with epilepsy (PWE) and their relatives. Epilepsy has a major impact on quality of life (QoL) in PWE and family members. However, less

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed0112c17673cf65f38a1d1e6941c84

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3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles Are Selective Inhibitors of Plasmodium falciparum Glycogen Synthase Kinase-3

Autor: Laurent Meijer, Narkiss Pressburger, Wiebke Fugel, Ilya Okun, Anselm Erich Oberholzer, Lutz Preu, Ron Dzikowski, Morgane Ratin, Blandine Baratte, Sebastian Kruggel, B Gschloessl, Christian Doerig, Conrad Kunick, Laurence H. Pearl, Thomas Lemcke

Publikováno v: Journal of Medicinal Chemistry; Vol 56

Plasmodium falciparum is the infective agent responsible for malaria tropica. The glycogen synthase kinase-3 of the parasite (PfGSK-3) was suggested as a potential biological target for novel antimalarial drugs. Starting from hit structures identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4569ae9ecb15661f2273c2ee7ed4c6c5

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Small substrate, big surprise: fold, function and phylogeny of dihydroxyacetone kinases

Autor: Anselm Erich Oberholzer, Sandra Christen, Bernhard Erni, Annapurna Srinivas, Ulrich Baumann, Christina Siebold

Publikováno v: Erni, Bernhard; Siebold, Christina; Christen, Sandra; Srinivas, Annapurna; Oberholzer, Anselm; Baumann, Ulrich (2006). Small substrate, big surprise: fold, function and phylogeny of dihydroxyacetone kinases. Cellular and molecular life sciences, 63(7-8), pp. 890-900. Basel: Birkhäuser-Verlag; www.birkhauser.ch 10.1007/s00018-005-5518-0

Dihydroxyacetone (Dha) kinases are a family of sequence-conserved enzymes which utilize either ATP (in animals, plants and eubacteria) or phosphoenolpyruvate (PEP, in eubacteria) as their source of high-energy phosphate. The kinases consist of two do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68d2f072c67059d0e8d4641e7ffd1b5
https://ora.ox.ac.uk/objects/uuid:a7db8fd3-b177-4b26-a005-236138aff36d

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Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

Autor: Claude Cochet, Guillaume Burgy, François Carreaux, Meera Soundararajan, Panagis Filippakopoulos, Anselm Erich Oberholzer, Emilie Durieu, Laurent Meijer, Jean Pierre Bazureau, Ralf S. Schmid, Florent Delhommel, Jonathan M. Elkins, Donald C. Lo, Tania Tahtouh, Laurence H. Pearl, Stefan Knapp

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2012, 55 (21), pp.9312-30. ⟨10.1021/jm301034u⟩
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (21), pp.9312-30. ⟨10.1021/jm301034u⟩

International audience; DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer's disease and Down syndrome. The marine sponge alkaloid leucettamine B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456717cb83042bce3cf7fc9a2b1011ce
https://doi.org/10.1021/jm301034u

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Structure and Function of CinD (YtjD) of Lactococcus lactis , a Copper-Induced Nitroreductase Involved in Defense against Oxidative Stress

Autor: Frédéric Mourlane, Ulrich Baumann, Sandro Waltersperger, Anselm Erich Oberholzer, Marc Solioz, Mélanie Mermod

Publikováno v: Journal of Bacteriology. 192:4172-4180

In Lactococcus lactis IL1403, 14 genes are under the control of the copper-inducible CopR repressor. This so-called CopR regulon encompasses the CopR regulator, two putative CPx-type copper ATPases, a copper chaperone, and 10 additional genes of unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccab2aecd4db141bd165b334b05f79e3
https://doi.org/10.1128/jb.00372-10

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Crystal Structure of the Phosphoenolpyruvate-binding Enzyme I-Domain from the Thermoanaerobacter tengcongensis PEP: Sugar Phosphotransferase System (PTS)

Autor: Ulrich Baumann, Anselm Erich Oberholzer, Christoph Bächler, Philipp Schneider, Christian Siebold, Bernhard Erni, Mario Bumann

Publikováno v: Journal of Molecular Biology. 346:521-532

Enzyme I (EI), the first component of the phosphoenolpyruvate (PEP):sugar phosphotransferase system (PTS), consists of an N-terminal protein-binding domain (EIN) and a C-terminal PEP-binding domain (EIC). EI transfers phosphate from PEP by double dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ae85159dcdcdec77407b33d4ce567b
https://doi.org/10.1016/j.jmb.2004.11.077

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Phosphoenolpyruvate: sugar phosphotransferase system from the hyperthermophilic Thermoanaerobacter tengcongensis

Autor: Vera Navdaeva, Ulrich Baumann, Andreas Zurbriggen, Philipp Schneider, Bernhard Erni, Sandro Waltersperger, Andreas Grieder, Priska Bähler, Anselm Erich Oberholzer, Christoph Bächler

Publikováno v: Biochemistry. 50(7)

Thermoanaerobacter tengcongensis is a thermophilic eubacterium that has a phosphoenolpyruvate (PEP) sugar phosphotransferase system (PTS) of 22 proteins. The general PTS proteins, enzyme I and HPr, and the transporters for N-acetylglucosamine (EIICB(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8e240f07fc39fd701d6ab73be0720e
https://pubmed.ncbi.nlm.nih.gov/21250658

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Crystal structure of enzyme I of the phosphoenolpyruvate sugar phosphotransferase system in the dephosphorylated state

Autor: Ulrich Baumann, Christian Siebold, Philipp Schneider, Bernhard Erni, Anselm Erich Oberholzer

Publikováno v: The Journal of biological chemistry. 284(48)

The bacterial phosphoenolpyruvate (PEP) sugar phosphotransferase system mediates sugar uptake and controls the carbon metabolism in response to carbohydrate availability. Enzyme I (EI), the first component of the phosphotransferase system, consists o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964e158dc8534e48a9a259077127cc6d
https://pubmed.ncbi.nlm.nih.gov/19801641

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