Zobrazeno 1 - 10
of 401
pro vyhledávání: '"Erich Hoffmann"'
Publikováno v:
Jahresberichte und Mitteilungen des Oberrheinischen Geologischen Vereins. 99:125-164
Autor:
Hui-Ling Yen, Aleksandr S. Lipatov, Rachelle Salomon, Hiroichi Ozaki, Erich Hoffmann, Robert G. Webster
Publikováno v:
Archives of Virology. 153:427-434
The N-terminal caspase cleavage in the nucleoprotein (NP) of influenza A virus is correlated with the host origin of the virus, thus could be a molecular determinant for host range. We studied how mutations targeting the NP cleavage motif of human an
Autor:
Natalia A. Ilyushina, Hui-Ling Yen, Erich Hoffmann, Rachelle Salomon, Elena A. Govorkova, Robert G. Webster
Publikováno v:
Journal of Virology. 81:12418-12426
Effective antiviral drugs are essential for early control of an influenza pandemic. It is therefore crucial to evaluate the possible threat posed by neuraminidase (NA) inhibitor-resistant influenza viruses with pandemic potential. Four NA mutations (
Autor:
Diane J. Hulse-Post, Hui-Ling Yen, Richard J. Webby, John Franks, David Walker, Erich Hoffmann, Kelli L. Boyd, Rachelle Salomon, Toan D. Nguyen, Robert G. Webster
Publikováno v:
Journal of Virology. 81:8515-8524
The highly pathogenic (HP) influenza viruses H5 and H7 are usually nonpathogenic in mallard ducks. However, the currently circulating HP H5N1 viruses acquired a different phenotype and are able to cause mortality in mallards. To establish the molecul
Autor:
Natalia A. Ilyushina, Charles J. Russell, Elena A. Govorkova, Erich Hoffmann, Robert G. Webster
Publikováno v:
Journal of General Virology. 88:1266-1274
In the present study we determined the antiviral effect of amantadine against influenza A/Netherlands/219/03 (H7N7) virus in cell culture and in a mouse model. Amantadine at concentrations −1 day−1 did not protect animals against lethal challenge
Autor:
Christoph Scholtissek, Hui-Ling Yen, Elena A. Govorkova, Robert G. Webster, Garry L. Taylor, Erich Hoffmann, Arnold S. Monto
Publikováno v:
Journal of Virology. 80:8787-8795
Neuraminidase inhibitors (NAIs) are antivirals designed to target conserved residues at the neuraminidase (NA) enzyme active site in influenza A and B viruses. The conserved residues that interact with NAIs are under selective pressure, but only a fe
Autor:
Rachelle Salomon, Erich Hoffmann, Robert G. Webster, Elena A. Govorkova, Natalia A. Ilyushina
Publikováno v:
Antiviral Therapy. 12:363-370
Background The clinical management of H5N1 influenza virus infection in humans remains unclear. Combination chemotherapy with drugs that target different viral proteins might be more effective than monotherapy. Methods BALB/c mice were treated by ora