Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Erich G Chapman"'
Autor:
Navneeta Kaul, Sarala J. Pradhan, Nathan G. Boin, Madeleine M. Mason, Julian Rosales, Emily L. Starke, Emily C. Wilkinson, Erich G. Chapman, Scott A. Barbee
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 11-22 (2024)
Fragile X Syndrome (FXS) is the most common inherited form of intellectual disability and is caused by mutations in the gene encoding the Fragile X messenger ribonucleoprotein (FMRP). FMRP is an evolutionarily conserved and neuronally enriched RNA-bi
Externí odkaz:
https://doaj.org/article/2ceefdce3e2846ea83bca36538c1d3c1
Publikováno v:
eLife, Vol 3 (2014)
Dengue virus is a growing global health threat. Dengue and other flaviviruses commandeer the host cell’s RNA degradation machinery to generate the small flaviviral RNA (sfRNA), a noncoding RNA that induces cytopathicity and pathogenesis. Host cell
Externí odkaz:
https://doaj.org/article/3e1986a94ca6477582777c03339950e3
Autor:
Cheyenne N. Phillips, Shawn Schowe, Conner J. Langeberg, Namoos Siddique, Erich G. Chapman, Marino J. E. Resendiz
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Understanding how oxidatively damaged RNA is handled intracellularly is of relevance due to the link between oxidized RNA and the progression/development of some diseases as well as aging. Among the ribonucleases responsible for the decay of modified
Externí odkaz:
https://doaj.org/article/ae6fee2a1eec4c9abe6763465da4a062
Autor:
Andrea MacFadden, Zoe O’Donoghue, Patricia A. G. C. Silva, Erich G. Chapman, René C. Olsthoorn, Mark G. Sterken, Gorben P. Pijlman, Peter J. Bredenbeek, Jeffrey S. Kieft
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally
Externí odkaz:
https://doaj.org/article/b7039c42c77c4ec68cc74cfb0a5e0764
Autor:
Navneeta Kaul, Sarala J. Pradhan, Nathan G. Boin, Madeleine M. Mason, Julian Rosales, Emily L. Starke, Emily C. Wilkinson, Erich G. Chapman, Scott A. Barbee
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and is caused by mutations in the gene encoding for the Fragile X messenger ribonucleoprotein (FMRP). FMRP is an evolutionarily conserved and neuronally enriched RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ddbf42a19f2ea123ff26faf5f7ce72d
https://doi.org/10.1101/2023.05.03.539280
https://doi.org/10.1101/2023.05.03.539280
Publikováno v:
J Vis Exp
RNA is a biopolymer present in all domains of life, and its interactions with other molecules and/or reactive species, e.g., DNA, proteins, ions, drugs, and free radicals, are ubiquitous. As a result, RNA undergoes various reactions that include its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659c5b5fc386afdf02ec7b2beac22862
https://doi.org/10.3791/63720-v
https://doi.org/10.3791/63720-v
Autor:
Conner J. Langeberg, Marino J. E. Resendiz, Shawn Schowe, Erich G. Chapman, Cheyenne N. Phillips, Namoos Siddique
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences, Vol 8 (2021)
Understanding how oxidatively damaged RNA is handled intracellularly is of relevance due to the link between oxidized RNA and the progression/development of some diseases as well as aging. Among the ribonucleases responsible for the decay of modified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2317b634ffc53702cab231961bc0c9
https://doi.org/10.3389/fmolb.2021.780315
https://doi.org/10.3389/fmolb.2021.780315
Structured RNA elements that protect RNA transcripts from 5’→3’ degradation are becoming useful research tools. Here we show that exonuclease-resistant RNA structures (xrRNAs) from Flaviviruses can be used to protect heterologous messenger RNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0379cf73517df040bef5bb81496798f
https://doi.org/10.1101/2020.06.25.169177
https://doi.org/10.1101/2020.06.25.169177
Autor:
John V. McGuire, Conner J. Langeberg, Erich G. Chapman, Alison Ashby, Alexander D. Jackson, William R. W. Welch
Publikováno v:
Biochemistry
Messenger RNA degradation is an important component of overall gene expression. During the final step of eukaryotic mRNA degradation, exoribonuclease 1 (Xrn1) carries out 5′ → 3′ processive, hydrolytic degradation of RNA molecules using divalen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0321c62e123e8c05597e9c5feffb9413
https://europepmc.org/articles/PMC7780157/
https://europepmc.org/articles/PMC7780157/
Autor:
Patrícia A. G. C. Silva, Zoe O'Donoghue, Peter J. Bredenbeek, Gorben P. Pijlman, Andrea MacFadden, Jeffrey S. Kieft, Mark G. Sterken, René C. L. Olsthoorn, Erich G. Chapman
Publikováno v:
Nature Communications
Nature Communications, 9. Springer Science and Business Media LLC
Nature Communications 9 (2018) 1
Nature Communications, 9(1)
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9
Nature Communications, 9. Springer Science and Business Media LLC
Nature Communications 9 (2018) 1
Nature Communications, 9(1)
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9
Flaviviruses such as Yellow fever, Dengue, West Nile, and Zika generate disease-linked viral noncoding RNAs called subgenomic flavivirus RNAs. Subgenomic flavivirus RNAs result when the 5′–3′ progression of cellular exoribonuclease Xrn1 is bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c602e76d1e5fe7e7b3a7ef0bd1bcafc
https://pubmed.ncbi.nlm.nih.gov/29317714
https://pubmed.ncbi.nlm.nih.gov/29317714