Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Erich E, Wanker"'
Autor:
Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A. M. Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C. Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E. Wanker, Josef Priller, Jakob J. Metzger, Alessandro Prigione
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Expansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic in
Externí odkaz:
https://doaj.org/article/340c015abcae4c679391b04ea77b6a41
Autor:
Philipp Trepte, Christopher Secker, Julien Olivet, Jeremy Blavier, Simona Kostova, Sibusiso B Maseko, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A Calderwood, David E Hill, Markus Landthaler, Soon Gang Choi, Jean-Claude Twizere, Marc Vidal, Erich E Wanker
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 4, Pp 428-457 (2024)
Abstract Protein–protein interactions (PPIs) offer great opportunities to expand the druggable proteome and therapeutically tackle various diseases, but remain challenging targets for drug discovery. Here, we provide a comprehensive pipeline that c
Externí odkaz:
https://doaj.org/article/bd1c8039d8764608818fd46023e76135
Autor:
Annett Boeddrich, Christian Haenig, Nancy Neuendorf, Eric Blanc, Andranik Ivanov, Marieluise Kirchner, Philipp Schleumann, Irem Bayraktaroğlu, Matthias Richter, Christine Mirjam Molenda, Anje Sporbert, Martina Zenkner, Sigrid Schnoegl, Christin Suenkel, Luisa-Sophie Schneider, Agnieszka Rybak-Wolf, Bianca Kochnowsky, Lauren M. Byrne, Edward J. Wild, Jørgen E. Nielsen, Gunnar Dittmar, Oliver Peters, Dieter Beule, Erich E. Wanker
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-32 (2023)
Abstract Background Alzheimer’s disease (AD) is characterized by the intra- and extracellular accumulation of amyloid-β (Aβ) peptides. How Aβ aggregates perturb the proteome in brains of patients and AD transgenic mouse models, remains largely u
Externí odkaz:
https://doaj.org/article/84f66523eef540e7aa35e8b03a0fbf0e
Autor:
Duncan C. Miller, Pawel Lisowski, Carolin Genehr, Erich E. Wanker, Josef Priller, Alessandro Prigione, Sebastian Diecke
Publikováno v:
Stem Cell Research, Vol 68, Iss , Pp 103056- (2023)
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an abnormal length of CAG repeats in the gene HTT, leading to an elongated poly-glutamine (poly-Q) sequence in huntingtin (HTT). We used non-integrative Sendai virus to
Externí odkaz:
https://doaj.org/article/5ee51186bc8e4931ae2ca8332a5817d8
Autor:
Duncan C. Miller, Pawel Lisowski, Selene Lickfett, Barbara Mlody, Miriam Bünning, Carolin Genehr, Claas Ulrich, Erich E. Wanker, Sebastian Diecke, Josef Priller, Alessandro Prigione
Publikováno v:
Stem Cell Research, Vol 65, Iss , Pp 102976- (2022)
Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal glutamine (Q) expansion in the huntingtin protein due to elongated CAG repeats in the gene HTT. We used non-integrative episomal plasmids to generate induced pluripotent s
Externí odkaz:
https://doaj.org/article/bb9f7998ccc941c989eb4b530769af6a
Autor:
Gizem Inak, Agnieszka Rybak-Wolf, Pawel Lisowski, Tancredi M. Pentimalli, René Jüttner, Petar Glažar, Karan Uppal, Emanuela Bottani, Dario Brunetti, Christopher Secker, Annika Zink, David Meierhofer, Marie-Thérèse Henke, Monishita Dey, Ummi Ciptasari, Barbara Mlody, Tobias Hahn, Maria Berruezo-Llacuna, Nikos Karaiskos, Michela Di Virgilio, Johannes A. Mayr, Saskia B. Wortmann, Josef Priller, Michael Gotthardt, Dean P. Jones, Ertan Mayatepek, Werner Stenzel, Sebastian Diecke, Ralf Kühn, Erich E. Wanker, Nikolaus Rajewsky, Markus Schuelke, Alessandro Prigione
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Leigh syndrome (LS) is a severe neurometabolic disorder which lacks effective models. Here, the authors developed human neuronal models of LS carrying mutations in SURF1 which show impaired neuronal morphogenesis due to metabolic deficiencies.
Externí odkaz:
https://doaj.org/article/7c5258ec4a0c4d51b4034db5722f87a1
Autor:
Franziska Schindler, Nicole Praedel, Nancy Neuendorf, Severine Kunz, Sigrid Schnoegl, Michael A. Mason, Bridget A. Taxy, Gillian P. Bates, Ali Khoshnan, Josef Priller, Jan Grimm, Marcel Maier, Annett Boeddrich, Erich E. Wanker
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The deposition of mutant huntingtin (mHTT) protein aggregates in neurons of patients is a pathological hallmark of Huntington’s disease (HD). Previous investigations in cell-free and cell-based disease models showed mHTT exon-1 (mHTTex1) fragments
Externí odkaz:
https://doaj.org/article/39b7832b713b418b99c771d5d66fad70
Autor:
Soon Gang Choi, Julien Olivet, Patricia Cassonnet, Pierre-Olivier Vidalain, Katja Luck, Luke Lambourne, Kerstin Spirohn, Irma Lemmens, Mélanie Dos Santos, Caroline Demeret, Louis Jones, Sudharshan Rangarajan, Wenting Bian, Eloi P. Coutant, Yves L. Janin, Sylvie van der Werf, Philipp Trepte, Erich E. Wanker, Javier De Las Rivas, Jan Tavernier, Jean-Claude Twizere, Tong Hao, David E. Hill, Marc Vidal, Michael A. Calderwood, Yves Jacob
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Comprehensive mapping of binary protein-protein interactions requires to combine several complementary assays. Here, the authors show that complete coverage could be reached with a minimal number of assays as long as they explore various experimental
Externí odkaz:
https://doaj.org/article/2f419fab78844c44ac0e5edf56d0f33d
Autor:
Ilka Wilhelmi, Stephan Grunwald, Niclas Gimber, Oliver Popp, Gunnar Dittmar, Anup Arumughan, Erich E. Wanker, Thomas Laeger, Jan Schmoranzer, Oliver Daumke, Annette Schürmann
Publikováno v:
Molecular Metabolism, Vol 45, Iss , Pp 101151- (2021)
Objective: Hormone secretion from metabolically active tissues, such as pancreatic islets, is governed by specific and highly regulated signaling pathways. Defects in insulin secretion are among the major causes of diabetes. The molecular mechanisms
Externí odkaz:
https://doaj.org/article/1448fb0556da4f3e9a968b2dfe04626d
Autor:
Miguel A. Andrade-Navarro, Katja Mühlenberg, Eike J. Spruth, Nancy Mah, Adrián González-López, Tommaso Andreani, Jenny Russ, Matthew R. Huska, Enrique M. Muro, Jean-Fred Fontaine, Vyacheslav Amstislavskiy, Alexei Soldatov, Wilfried Nietfeld, Erich E. Wanker, Josef Priller
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a trinucleotide repeat expansion in the Huntingtin gene. As disease-modifying therapies for HD are being developed, peripheral blood cells may be used
Externí odkaz:
https://doaj.org/article/925b06c38d3f4fc9b92bb87159e9a54c