Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression

Autor: Ilse M. Boudewijn, Alen Faiz, Katrina Steiling, Erica van der Wiel, Eef D. Telenga, Susan J. M. Hoonhorst, Nick H. T. ten Hacken, Corry-Anke Brandsma, Huib A. M. Kerstjens, Wim Timens, Irene H. Heijink, Marnix R. Jonker, Harold G. de Bruin, J. Sebastiaan Vroegop, Henk R. Pasma, Wim G. Boersma, Pascal Wielders, Frank van den Elshout, Khaled Mansour, Avrum Spira, Marc E. Lenburg, Victor Guryev, Dirkje S. Postma, Maarten van den Berge

Publikováno v: Respiratory Research, Vol 18, Iss 1, Pp 1-10 (2017)

Abstract Background Nasal gene expression profiling is a promising method to characterize COPD non-invasively. We aimed to identify a nasal gene expression profile to distinguish COPD patients from healthy controls. We investigated whether this COPD-

Externí odkaz: https://doaj.org/article/65ad28ccc1de4dada65462a59303ada5

Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD

Autor: Frank van den Elshout, Marc E. Lenburg, Wim Timens, Alen Faiz, Dirkje S. Postma, Corry-Anke Brandsma, Wim Boersma, Erica van der Wiel, Kai Imkamp, Sebastiaan J. Vroegop, Maarten van den Berge, Gerard H. Koppelman, Avrum Spira, Huib A. M. Kerstjens, Katrina Steiling, Henk R. Pasma, Ilse M. Boudewijn, Pascal Wielders, Irene H. Heijink, Khaled Mansour

Publikováno v: Scientific Reports, 10(1):17415, 1-12. Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

Hyperinflation contributes to dyspnea intensity in COPD. Little is known about the molecular mechanisms underlying hyperinflation and how inhaled corticosteroids (ICS) affect this important aspect of COPD pathophysiology. To investigate the effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc126d4b0cf667d4b408e24d6867a7ec
https://doi.org/10.1038/s41598-020-72551-0

Targeting the small airways with dry powder adenosine

Autor: Maarten van den Berge, Erica van der Wiel, Anne H. de Boer, Nick H. T. ten Hacken, Martijn P. Farenhorst, Paul Hagedoorn, Dirkje S. Postma, Henderik W. Frijlink, Anne J. Lexmond

Publikováno v: European Clinical Respiratory Journal
European Clinical Respiratory Journal, Vol 4, Iss 1 (2017)
European clinical respiratory journal, 4(1):1369328. Taylor & Francis Group

Background: Small-particle inhaled corticosteroids (ICS) provide a higher small airway deposition than large-particle ICS. However, we are still not able to identify asthma patients who will profit most from small-particle treatment. Objective: We ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171af487f701ca889e30497dba4392bf
https://research.rug.nl/en/publications/d98bfa31-5468-410f-97ef-4240b55ebedd

Adenosine dry powder inhalation for bronchial challenge testing, part 2: Proof of concept in asthmatic subjects

Autor: Nick H. T. ten Hacken, Anne J. Lexmond, Wouter Bult, Henderik W. Frijlink, Paul Hagedoorn, Erica van der Wiel, Anne H. de Boer

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics, 88(1), 148-152. ELSEVIER SCIENCE BV

Adenosine is an indirect stimulus to assess bronchial hyperresponsiveness (BHR(2)) in asthma. Bronchial challenge tests are usually performed with nebulised solutions of adenosine 5'-monophosphate (AMP(3)). The nebulised AMP test has several disadvan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36da8262f501a70a201459fd53d8e4b
https://doi.org/10.1016/j.ejpb.2014.04.008

Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: A systematic review

Autor: Erica van der Wiel, Dirkje S. Postma, Maarten van den Berge, Nick H. T. ten Hacken

Publikováno v: Journal of Allergy and Clinical Immunology. 131:646-657

Traditionally, asthma has been considered a disease that predominantly involves the large airways. Today, this concept is being challenged, and increasing evidence has become available showing that abnormalities in the small airways also contribute t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29637105b3b19de36996eddfbfe374d0
https://doi.org/10.1016/j.jaci.2012.12.1567