Constructing a gnotobiotic mouse model with a synthetic human gut microbiome to study host–microbe cross talk

Autor: Alex Steimle, Alessandro De Sciscio, Mareike Neumann, Erica T. Grant, Gabriel V. Pereira, Hiroshi Ohno, Eric C. Martens, Mahesh S. Desai

Publikováno v: STAR Protocols, Vol 2, Iss 2, Pp 100607- (2021)

Summary: Reproducible in vivo models are necessary to address functional aspects of the gut microbiome in various diseases. Here, we present a gnotobiotic mouse model that allows for the investigation of specific microbial functions within the microb

Externí odkaz: https://doaj.org/article/faee353c464c4ed4ad015b89830f2e5b

Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium

Autor: Mareike Neumann, Alex Steimle, Erica T. Grant, Mathis Wolter, Amy Parrish, Stéphanie Willieme, Dirk Brenner, Eric C. Martens, Mahesh S. Desai

Publikováno v: Gut Microbes, Vol 13, Iss 1 (2021)

The change of dietary habits in Western societies, including reduced consumption of fiber, is linked to alterations in gut microbial ecology. Nevertheless, mechanistic connections between diet-induced microbiota changes that affect colonization resis

Externí odkaz: https://doaj.org/article/533332f5f3bf4e4495a6be7d56804884

Leveraging diet to engineer the gut microbiome

Autor: Mathis Wolter, Erica T. Grant, Eric C. Martens, Mahesh Desai, Gabriel V. Pereira, Alex Steimle, Marie Boudaud

Publikováno v: Wolter, M, Grant, E T, Boudaud, M, Steimle, A, Pereira, G V, Martens, E C & Desai, M S 2021, ' Leveraging diet to engineer the gut microbiome ', Nature Reviews Gastroenterology and Hepatology, vol. 18, no. 12, pp. 885-902 . https://doi.org/10.1038/s41575-021-00512-7

Autoimmune diseases, including inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, have distinct clinical presentations but share underlying patterns of gut microbiome perturbation and intestinal barrier dysfunction. Their potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efde8b3b91e76a3fe15b7bafce6da720
https://doi.org/10.1038/s41575-021-00512-7

Long-Tailed Macaques (Macaca fascicularis) in Urban Landscapes: Gastrointestinal Parasitism and Barriers for Healthy Coexistence in Northeast Thailand

Autor: Sally Trufan, Stephen T. Kelley, Gemina Garland-Lewis, Pensri Kyes, Tawatchai Tanee, Vickie Ramirez, Penkhae Thamsenanupap, Natcha Patarapadungkit, Hutsacha Nueaitong, Peter M. Rabinowitz, Randall C. Kyes, Janna M. Schurer, Erica T. Grant

Publikováno v: The American Journal of Tropical Medicine and Hygiene. 100:357-364

Gastrointestinal parasites have diverse life cycles that can involve people, animals, and the environment (e.g., water and soil), demonstrating the utility of One Health frameworks in characterizing infection risk. Kosumpee Forest Park (Thailand) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0753c757faceae18cd3f3ea2d4a0dddc
https://doi.org/10.4269/ajtmh.18-0241

Concentrated Raw Fibers Enhance the Fiber-Degrading Capacity of a Synthetic Human Gut Microbiome

Autor: Jonathan D. Turner, Mareike Neumann, Erica T. Grant, Mahesh Desai, Alexander Steimle

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 6855, p 6855 (2021)
Steimle, A, Neumann, M, Grant, E T, Turner, J D & Desai, M S 2021, ' Concentrated raw fibers enhance the fiber-degrading capacity of a synthetic human gut microbiome ', International Journal of Molecular Sciences, vol. 22, no. 13, 6855 . https://doi.org/10.3390/ijms22136855
Volume 22
Issue 13

The consumption of prebiotic fibers to modulate the human gut microbiome is a promising strategy to positively impact health. Nevertheless, given the compositional complexity of the microbiome and its inter-individual variances, generalized recommend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16723a632acd5475c229eca9e22454b8
https://doi.org/10.3390/ijms22136855