Assessment of Methods for the Intracellular Blockade of GABAA Receptors.

Autor: Laura A Atherton, Erica S Burnell, Jack R Mellor

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160900 (2016)

Selective blockade of inhibitory synaptic transmission onto specific neurons is a useful tool for dissecting the excitatory and inhibitory synaptic components of ongoing network activity. To achieve this, intracellular recording with a patch solution

Externí odkaz: https://doaj.org/article/d54d470bda034022849b2787e143d7c9

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Autor: Minjun Li, David E. Jane, Graham L. Collingridge, Erica S. Burnell, Robert J. Thatcher, Kiran Sapkota, Arturas Volianskis, Daniel T. Monaghan, Noriko Simorowski, Hiro Furukawa, Mark W. Irvine, Jue Xiang Wang

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Wang, J X, Irvine, M W, Burnell, E S, Sapkota, K, Thatcher, R J, Li, M, Simorowski, N, Volianskis, A, Collingridge, G L, Monaghan, D T, Jane, D E & Furukawa, H 2020, ' Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors ', Nature Communications, vol. 11, no. 1, 423 . https://doi.org/10.1038/s41467-020-14321-0
Nature Communications

N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88f84ba3487ef9967bcf8d4394ee1ae

Drugs targeting mitochondrial functions

Autor: Erica S. Burnell

This chapter provides an overview of the design and development of antimalarial drugs acting on targets within the mitochondrion of the malaria parasite. The three mitochondrial targets that have been most successful with regards to drug development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::680facf919fe92d486d1004dca25531e
https://doi.org/10.1016/b978-0-08-101210-9.00010-x

Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792

Autor: Shashank M. Dravid, Kiran Sapkota, Daniel T. Monaghan, Erica S. Burnell, David E. Jane, Mark W. Irvine, Guangyu Fang, Dinesh Y. Gawande

Publikováno v: Neuropharmacology. 201:108818

N-methyl- d -aspartate (NMDA) receptors (NMDARs) are a subtype of ionotropic glutamate receptor with important roles in CNS function. Since excessive NMDAR activity can lead to neuronal cell death and epilepsy, there is interest in developing NMDAR n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6206924b5904f9414ae8507790ab847
https://doi.org/10.1016/j.neuropharm.2021.108818

Positive and Negative Allosteric Modulators of N-Methyl- d -aspartate (NMDA) Receptors:Structure-Activity Relationships and Mechanisms of Action

Autor: David E. Jane, Daniel T. Monaghan, Erica S. Burnell, Kiran Sapkota, Guangyu Fang, Mark W. Irvine

Publikováno v: Burnell, E S, Irvine, M, Fang, G, Sapkota, K, Jane, D E & Monaghan, D T 2019, ' Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors : Structure-Activity Relationships and Mechanisms of Action ', Journal of Medicinal Chemistry, vol. 62, no. 1, pp. 3-23 . https://doi.org/10.1021/acs.jmedchem.7b01640

Excitatory activity in the CNS is predominately mediated by l-glutamate through several families of l-glutamate neurotransmitter receptors. Of these, the N-methyl-d-aspartate receptor (NMDAR) family has many critical roles in CNS function and in vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e64a9a4b36cd6a367632d71ee3ffab1
http://www.scopus.com/inward/record.url?scp=85059506923&partnerID=8YFLogxK