Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Erica P. Cai"'
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102155- (2023)
Summary: Autoimmunity-induced pancreatic beta cell failure is the main characteristic of type 1 diabetes (T1D). Here, we describe a protocol for genome-scale in vivo CRISPR-Cas9 screening for use in a mouse model of T1D. Using a non-obese-diabetic-de
Externí odkaz:
https://doaj.org/article/3beefa1d3d474167871e947a9d11e340
Autor:
Christopher J. Contreras, Noyonika Mukherjee, Renato C.S. Branco, Li Lin, Meghan F. Hogan, Erica P. Cai, Andrew A. Oberst, Steven E. Kahn, Andrew T. Templin
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101582- (2022)
Objective: Type 1 diabetes (T1D) is characterized by autoimmune-associated β-cell loss, insulin insufficiency, and hyperglycemia. Although TNFα signaling is associated with β-cell loss and hyperglycemia in non-obese diabetic mice and human T1D, th
Externí odkaz:
https://doaj.org/article/7d60d82919e94293aee44d1fed96ab69
Autor:
Cynthia T. Luk, Sally Yu Shi, Erica P. Cai, Tharini Sivasubramaniyam, Mansa Krishnamurthy, Jara J. Brunt, Stephanie A. Schroer, Daniel A. Winer, Minna Woo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The kinase FAK is important for integrin signalling and promotes cell survival. Here, the authors demonstrate FAK regulates adipocyte survival, and is particularly important for maintaining insulin sensitivity during adipose tissue expansion in the c
Externí odkaz:
https://doaj.org/article/5d165920dc0744d7a47a01caacc2dd90
Autor:
Kevin Bode, Tara MacDonald, Taylor Stewart, Bryhan Mendez, Erica P. Cai, Noelle Morrow, Yu-Chi Lee, Peng Yi, Stephan Kissler
Publikováno v:
Diabetes.
Type 1 diabetes (T1D) is caused by the immune-mediated loss of pancreatic beta cells that produce insulin. The latest advances in stem cell (SC)-beta cell differentiation methods have made a cell replacement therapy for T1D feasible. However, recurri
Autor:
Stephan Kissler, Peng Yi, Yu-Chi Lee, Noelle Morrow, Erica P. Cai, Bryhan Mendez, Taylor Stewart, Tara MacDonald, Kevin Bode
Type 1 diabetes (T1D) is caused by the immune-mediated loss of pancreatic beta cells that produce insulin. The latest advances in stem cell (SC)-beta cell differentiation methods have made a cell replacement therapy for T1D feasible. However, recurri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab250618349bd5772c3a1ed9c97edd3
https://doi.org/10.2337/figshare.22898705.v1
https://doi.org/10.2337/figshare.22898705.v1
Autor:
Jian Li, Peng Yi, Nayara C. Leite, Nese Kurt Yilmaz, Yuki Ishikawa, Jennifer Hollister-Lock, Stephan Kissler, Erica P. Cai, Douglas A. Melton, Badr Kiaf, Wei Zhang, Shurong Hou, Celia A. Schiffer
Publikováno v:
Nature metabolism
Type 1 diabetes (T1D) is caused by the autoimmune destruction of pancreatic beta cells. Pluripotent stem cells can now be differentiated into beta cells, thus raising the prospect of a cell replacement therapy for T1D. However, autoimmunity would rap
Autor:
David W. Dodington, Min Jeong Kim, Sally Yu Shi, Lauren Lin, Minna Woo, Cynthia T. Luk, Kay Uwe Wagner, Erica P. Cai, Richard P. Bazinet, Shun Yan Lu, Stephanie A. Schroer, Tharini Sivasubramaniyam
Publikováno v:
Journal of Biological Chemistry. 292:3789-3799
Hepatocellular carcinoma is an end-stage complication of non-alcoholic fatty liver disease (NAFLD). Inflammation plays a critical role in the progression of non-alcoholic fatty liver disease and the development of hepatocellular carcinoma. However, w
Autor:
Erica P. Cai, Daniel A. Winer, Stephanie A. Schroer, Minna Woo, Tharini Sivasubramaniyam, Jara J. Brunt, Sally Yu Shi, Mansa Krishnamurthy, Cynthia T. Luk
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Focal adhesion kinase (FAK) plays a central role in integrin signalling, which regulates growth and survival of tumours. Here we show that FAK protein levels are increased in adipose tissue of insulin-resistant obese mice and humans. Disruption of ad
Publikováno v:
Endocrinology. 154:3652-3659
The growing prevalence of obesity and diabetes necessitate a better understanding of the role of adipocyte biology in metabolism. Increasingly, erythropoietin (EPO) has been shown to have extraerythropoietic and cytoprotective roles. Exogenous admini
Autor:
Youhou Kang, Diana Choi, Erica P. Cai, Stephanie A. Schroer, Dan Zhu, Patrick P.L. Lam, Minna Woo, Yunfeng Liu, Herbert Y. Gaisano, Yi Zhang
Publikováno v:
Canadian Journal of Diabetes. 36:251-256
Objective We recently reported that vesicle-associated membrane protein (VAMP) isoform 8 deletion increased islet β-cell mass. We now sought to determine if VAMP8 deletion-induced increase in islet β-cell mass would provide protection against strep