Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Erica Miraglia"'
Autor:
Roger Strömberg, Erica Miraglia, Birgitta Agerberth, Protim Sarker, Frank Nylén, Gudmundur H. Gudmundsson, Peter Bergman, Håkan Ottosson, Rubhana Raqib
Publikováno v:
Scientific Reports
A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vi
Autor:
Frank Nylén, Andreas Cederlund, Birgitta Agerberth, Peter Bergman, Erica Miraglia, Gudmundur H. Gudmundsson
Publikováno v:
Journal of Innate Immunity. 6:365-376
Antimicrobial peptides are important for a healthy host-microbe homeostasis. In infections characterized by low levels of the human cathelicidin, LL-37, induction of its expression increases clearance of pathogens. Our aim was to discover signaling p
Autor:
Erica Miraglia, Håkan Ottosson, Frank Nylén, Gudmundur H. Gudmundsson, Roger Strömberg, Andreas Cederlund, Birgitta Agerberth
Publikováno v:
Innate Immunity. 20:364-376
Innate immunity, the front line of our defence against pathogens, relies, to a great extent, on the production of antimicrobial peptides (AMPs). These peptides exhibit antimicrobial activity and immunomodulatory properties. In humans, AMPs include th
Autor:
Erica Miraglia, Frank Nylén, Birgitta Agerberth, Susan Farmand, Gudmundur H. Gudmundsson, Peter Bergman, Håkan Ottosson, Elias S.J. Arnér, Roger Strömberg, Katarina Johansson, Marcus Cebula
Publikováno v:
Scientific Reports
Bacterial resistance against classical antibiotics is a growing problem and the development of new antibiotics is limited. Thus, novel alternatives to antibiotics are warranted. Antimicrobial peptides (AMPs) are effector molecules of innate immunity
Autor:
Dario Ghigo, Elena Gazzano, Alberto Revelli, Alessia Cipriani, Cinzia Racca, Cristina Lussiana, Daniele Viarisio, Erica Miraglia, Amalia Bosia
Publikováno v:
Fertility and Sterility. 93:2437-2440
In swim-up-selected spermatozoa of 38 normozoospermic patients, capacitated spermatozoa exhibited enhanced pentose phosphate pathway (PPP) activity and increased expression of glucose-6-phosphate dehydrogenase (G6PD). The G6PD inhibitor DHEA and the
Autor:
Sophie Doublier, Chiara Riganti, Dario Ghigo, Daniele Viarisio, Gianpiero Pescarmona, Erica Miraglia, Amalia Bosia
Publikováno v:
British Journal of Pharmacology. 156:1054-1066
Background and purpose Artemisinin is an antimalarial drug exerting pleiotropic effects, such as the inhibition of the transcription factor nuclear factor-kappa B and of the sarcoplasmic/endoplasmic reticulum Ca(++)-ATPase (SERCA) of P. falciparum. A
Autor:
Amalia Bosia, Chiara Riganti, Sophie Doublier, Manuela Polimeni, Erica Miraglia, Dario Antonio Ghigo, Costanzo Costamagna
Publikováno v:
Toxicology and Applied Pharmacology. 228:277-285
We have recently shown that apocynin elicits an oxidative stress in N11 mouse glial cells and other cell types. Here we report that apocynin increased the accumulation of nitrite, the stable derivative of nitric oxide (NO), in the extracellular mediu
Autor:
Marco Massobrio, Dario Ghigo, Alberto Revelli, Maria Luisa Rullo, Erica Miraglia, Amalia Bosia
Publikováno v:
Fertility and Sterility. 87:1059-1063
Objective To investigate whether nitric oxide (NO) may attract human spermatozoa via activation of the soluble guanylate cyclase (sGC)/cyclic guanosine monophosphate (cGMP) pathway. Design Prospective study. Setting Academic research institution. Pat
Autor:
Erica Miraglia, Amalia Bosia, Costanzo Costamagna, Dario Ghigo, Daniele Viarisio, Chiara Riganti
Publikováno v:
International Journal of Cancer. 115:924-929
Multidrug resistant (MDR) tumor cells exhibit an altered pH gradient across different cell compartments, which favors a reduced intracellular accumulation of antineoplastic drugs and a decreased therapeutic effect. In our study, we have observed that
Publikováno v:
International Journal of Oncology.
Statins are cholesterol lowering drugs that exhibit antitumor effects in several in vitro and in vivo models, and epidemiological studies indicate that statins prevent cancer. However, the molecular mechanism underlying the effects of statins still n