Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Erica L. Bradshaw"'
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Akademický článek
Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
Autor: Erica L. Bradshaw, Mary E. Spilker, Richard Zang, Loveleena Bansal, Handan He, Rhys D.O. Jones, Kha Le, Mark Penney, Edgar Schuck, Brian Topp, Alice Tsai, Christine Xu, Marjoleen J.M.A. Nijsen, Jason R. Chan
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 777-791 (2019)
Abstract Quantitative systems pharmacology (QSP) approaches have been increasingly applied in the pharmaceutical since the landmark white paper published in 2011 by a National Institutes of Health working group brought attention to the discipline. In
Externí odkaz: https://doaj.org/article/cfab4d71279e43a58805b6626dcdac0c
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2
Akademický článek
Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer
Autor: Peter J. Klauck, Stacey M. Bagby, Anna Capasso, Erica L. Bradshaw-Pierce, Heather M. Selby, Anna Spreafico, John J. Tentler, Aik Choon Tan, Jihye Kim, John J. Arcaroli, Alicia Purkey, Wells A. Messersmith, Keisuke Kuida, S. Gail Eckhardt, Todd M. Pitts
Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key regulator of multiple stages of mitotic progression. Plk1 is upregulated in many tumor types including colorectal cancer (CRC) and portends a poor prognosis. TAK
Externí odkaz: https://doaj.org/article/d4dd779ae0964c9eb1a995ae2b3952c9
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3
Akademický článek
Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models
Autor: S. Lindsey eDavis, Kelli M. Robertson, Todd M. Pitts, John J. Tentler, Erica L. Bradshaw-Pierce, Peter J. Klauck, Stacey M. Bagby, Stephanie L. Hyatt, Heather M. Selby, Anna eSpreafico, Jeffrey A Ecsedy, John J. Arcaroli, Wells A. Messersmith, Aik Choon eTan, S. Gail eEckhardt
Publikováno v: Frontiers in Pharmacology, Vol 6 (2015)
Aurora A kinase and MEK inhibitors induce different, and potentially complementary, effects on the cell cycle of malignant cells, suggesting a rational basis for utilizing these agents in combination. In this work, the combination of an Aurora A kina
Externí odkaz: https://doaj.org/article/5f6654c44590401dbc1d91d387e8147f
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9
Data from Found in Translation: Maximizing the Clinical Relevance of Nonclinical Oncology Studies
Autor: Paolo Vicini, Erica L. Bradshaw-Pierce, Judy Lucas, Gang Li, Shinji Yamazaki, Chandra Vage, Ravi Visswanathan, Xiaoying Chen, Mary E. Spilker
Purpose: The translation of nonclinical oncology studies is a subject of continuous debate. We propose that translational oncology studies need to optimize both pharmacokinetic (drug exposure) and pharmacodynamic (xenograft model) aspects. While impr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f3b5251c6cb1f7d159009e3d3a9100
https://doi.org/10.1158/1078-0432.c.6526479.v1
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