Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Erica L, Fletcher"'
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction and death of the photoreceptors and retinal pigment epithelium (RPE). Innate immune cell activation and accompanying para
Externí odkaz:
https://doaj.org/article/d413f7a802f14a9ba28097a5708dbb74
Autor:
Hallur Reynisson, Michael Kalloniatis, Erica L. Fletcher, Mohit N. Shivdasani, Lisa Nivison-Smith
Publikováno v:
Frontiers in Neuroanatomy, Vol 17 (2023)
IntroductionA hallmark of photoreceptor degenerations is progressive, aberrant remodeling of the surviving retinal neurons and glia following photoreceptor loss. The exact relationship between neurons and glia remodeling in this late stage of retinal
Externí odkaz:
https://doaj.org/article/0c354ed797754e768bcc1b0f94c3f067
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Neovascular AMD (nAMD) leads to vision loss and is a leading cause of visual impairment in the industrialised world. Current treatments that target blood vessel growth have not been able to treat subretinal fibrosis and nAMD patients continu
Externí odkaz:
https://doaj.org/article/9c321a43bb704a35b001b8c5b72cf379
Autor:
Josephine H. C. Wong, Jessica Y. W. Ma, Andrew I. Jobling, Alice Brandli, Ursula Greferath, Erica L. Fletcher, Kirstan A. Vessey
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the older population. Classical hallmarks of early and intermediate AMD are accumulation of drusen, a waste deposit formed under the retina, and pigmentary abnor
Externí odkaz:
https://doaj.org/article/7a461a36e84249eebe75654648f35fae
Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time
Autor:
Grace E. Lidgerwood, Anne Senabouth, Casey J.A. Smith-Anttila, Vikkitharan Gnanasambandapillai, Dominik C. Kaczorowski, Daniela Amann-Zalcenstein, Erica L. Fletcher, Shalin H. Naik, Alex W. Hewitt, Joseph E. Powell, Alice Pébay
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 19, Iss 2, Pp 223-242 (2021)
Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accurate modelling of diseases associated with maturity or age. Hence, it is important to characterise how closely cells use
Externí odkaz:
https://doaj.org/article/a1b752ada11e4c119fcf167e7656b297
Autor:
Anna Y. M. Wang, Vickie H. Y. Wong, Pei Ying Lee, Bang V. Bui, Stefanie Dudczig, Kirstan A. Vessey, Erica L. Fletcher
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract There is increasing evidence for the vulnerability of specific retinal ganglion cell (RGC) types in those with glaucoma and in animal models. In addition, the P2X7-receptor (P2X7-R) has been suggested to contribute to RGC death following sti
Externí odkaz:
https://doaj.org/article/d9083722c2204c03bafe2c974c82c662
Autor:
Jessica Y.W. Ma, Ursula Greferath, Josephine H.C. Wong, Linda J. Fothergill, Andrew I. Jobling, Kirstan A. Vessey, Erica L. Fletcher
Publikováno v:
Neurobiology of Aging. 128:1-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9065b6d9847b4bcc51ccf4f163ddcf34
https://doi.org/10.1016/j.neurobiolaging.2023.03.003
https://doi.org/10.1016/j.neurobiolaging.2023.03.003
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Microglia, the resident immune cells of the central nervous system (CNS), were once considered quiescent cells that sat in readiness for reacting to disease and injury. Over the last decade, however, it has become clear that microglia play essential
Externí odkaz:
https://doaj.org/article/27dc90e2fdd44d4794e7b062efd1d495
Autor:
Ben J. Gu, Xin Huang, Pavan K. Avula, Emily Caruso, Candace Drysdale, Kirstan A. Vessey, Amber Ou, Christopher Fowler, Tian-Hua Liu, Yong Lin, Adam Horton, Colin L. Masters, James S. Wiley, Robyn H. Guymer, Erica L. Fletcher
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Age-related macular degeneration (AMD) is characterized by the accumulation of debris in the posterior eye. In this study we evaluated peripheral blood monocyte phagocytic function at various stages of AMD and in aged matched control participants. Re
Externí odkaz:
https://doaj.org/article/46bdd72e10094b2f8229071672c38f6d
Autor:
Kiana Kakavand, Andrew I. Jobling, Ursula Greferath, Kirstan A. Vessey, Robb U. de Iongh, Erica L. Fletcher
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Photoreceptor death contributes to 50% of irreversible vision loss in the western world. Pro23His (P23H) transgenic albino rat strains are widely used models for the most common rhodopsin gene mutation associated with the autosomal dominant form of r
Externí odkaz:
https://doaj.org/article/6f4169eef20540858345535f0fb8a25b