Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo.

Autor: Felix Ellett, Vahid Pazhakh, Luke Pase, Erica L Benard, Harshini Weerasinghe, Denis Azabdaftari, Sultan Alasmari, Alex Andrianopoulos, Graham J Lieschke

Publikováno v: PLoS Pathogens, Vol 14, Iss 6, p e1007063 (2018)

Neutrophils and macrophages provide the first line of cellular defence against pathogens once physical barriers are breached, but can play very different roles for each specific pathogen. This is particularly so for fungal pathogens, which can occupy

Externí odkaz: https://doaj.org/article/5bec83a24f15453abbf5e5e902ce04b5

Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling

Autor: Herman P. Spaink, Erica L. Benard, Stefan J. Roobol, Annemarie H. Meijer

Publikováno v: Developmental & Comparative Immunology. 47:223-233

Scavenger receptors on the cell surface of macrophages play an important role in host defence through their ability to bind microbial ligands and induce phagocytosis. Concurrently, signal transduction pathways are initiated that aid in defence mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b1eeefdd5d61e00bbe3e6065d77d44
https://doi.org/10.1016/j.dci.2014.07.022

Macrophage-specific gene functions in Spi1-directed innate immunity

Autor: Anna Zakrzewska, Erica L. Benard, Annemarie H. Meijer, Herman P. Spaink, Oliver W. Stockhammer, Chao Cui

Publikováno v: ResearcherID
Blood, 116(3), e1-11. American Society of Hematology

The Spi1/Pu.1 transcription factor plays a crucial role in myeloid cell development in vertebrates. Despite extensive studies of Spi1, the controlled gene group remains largely unknown. To identify genes dependent on Spi1, we used a microarray strate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a1a17cef862fc52b7b39bf5c9070ad
https://doi.org/10.1182/blood-2010-01-262873

Infection of zebrafish embryos with intracellular bacterial pathogens

Autor: Astrid M. van der Sar, Felix Ellett, Erica L. Benard, Graham J. Lieschke, Annemarie H. Meijer, Herman P. Spaink

Publikováno v: Journal of Visualized Experiments : JoVE
Scopus-Elsevier
Benard, E L, van der Sar, A M, Ellett, F, Lieschke, G J, Spaink, H P & Meijer, A H 2012, ' Infection of zebrafish embryos with intracellular bacterial pathogens ', Journal of Visualized Experiments, vol. 15, no. 61, e3781 . https://doi.org/10.3791/3781
Journal of Visualized Experiments, 15(61):e3781. MYJoVE Corporation

Zebrafish (Danio rerio) embryos are increasingly used as a model for studying the function of the vertebrate innate immune system in host-pathogen interactions 1. The major cell types of the innate immune system, macrophages and neutrophils, develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4760065b2636054d171ac231c805c7
https://pubmed.ncbi.nlm.nih.gov/22453760

Infectious Disease Modeling and Innate Immune Function in Zebrafish Embryos

Autor: Michiel van der Vaart, Oliver W. Stockhammer, Herman P. Spaink, Anna Zakrzewska, Zakia Kanwal, Annemarie H. Meijer, Erica L. Benard, Chao Cui

The major cell types of the innate immune system, macrophages and neutrophils, develop during the first two days of zebrafish embryogenesis. The interaction of these immune cells with pathogenic microbes can excellently be traced in the optically tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c51600a4617ee786d4d912c9cebced8
https://doi.org/10.1016/b978-0-12-381320-6.00012-6