Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Erica Klaassen"'
Autor:
Eva Thijssen, Bert Tuk, Michel Cakici, Veerle vanVelze, Erica Klaassen, Frans Merkus, Teus vanLaar, Philip Kremer, Geert Jan Groeneveld
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Abstract Apomorphine, used to treat OFF episodes in patients with Parkinson's disease (PD), is typically administered via subcutaneous injections. Administration of an oromucosal solution could offer a non‐invasive and user‐friendly alternative.
Externí odkaz:
https://doaj.org/article/b89f94e53ffc45488671639f383ea4eb
Autor:
Sebastiaan J. W. vanKraaij, Diana R. Pereira, Bastiaan Smal, Luciana Summo, Anne Konkel, Janine Lossie, Andreas Busjahn, Tom N. Grammatopoulos, Erica Klaassen, Robert Fischer, Wolf‐Hagen Schunck, Pim Gal, Matthijs Moerland
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 7, Pp 1258-1271 (2023)
Abstract The development of pharmacological therapies for mitochondrial diseases is hampered by the lack of tissue‐level and circulating biomarkers reflecting effects of compounds on endothelial and mitochondrial function. This phase 0 study aimed
Externí odkaz:
https://doaj.org/article/994c545b4faf49d8965af13ecec37248
Autor:
Francis Dijkstra, Patricio O’Donnell, Erica Klaassen, Derek Buhl, Mahnaz Asgharnejad, Laura Rosen, Rob Zuiker, Joop van Gerven, Gabriël Jacobs
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract TAK-653 is a novel AMPA receptor positive allosteric modulator in clinical development for the treatment of major depressive disorder (MDD). This study aimed to measure the functional pharmacodynamic central nervous system (CNS) effects of T
Externí odkaz:
https://doaj.org/article/62a8cd476bd44bbca0c331fce96852f3
Autor:
Sebastiaan J. W. van Kraaij, Diana R. Pereira, Bastiaan Smal, Luciana Summo, Anne Konkel, Janine Lossie, Andreas Busjahn, Tom N. Grammatopoulos, Erica Klaassen, Robert Fischer, Wolf‐Hagen Schunck, Pim Gal, Matthijs Moerland
The development of pharmacological therapies for mitochondrial diseases is hampered by the lack of tissue-level and circulating biomarkers reflecting effects of compounds on endothelial and mitochondrial function. This phase 0 study aimed to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89dc274fab140f77179c6c3db555d4e
http://edoc.mdc-berlin.de/23361/1/23361oa.pdf
http://edoc.mdc-berlin.de/23361/1/23361oa.pdf
Autor:
Sebastiaan Kraaij, Laura Borghans, Erica Klaassen, Pim Gal, Jeroen van der Grond, Ken Tripp, Chris Winrow, Chad Glasser, Geert Jan Groeneveld
Aim Dysfunction of nitric oxide (NO) – soluble guanylate cyclase (sGC) – cyclic guanosine monophosphate (cGMP) signalling is implicated in the pathophysiology of cognitive impairment and dementia. Zagociguat is a central nervous system-(CNS-) pen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e5111b20a4145a1cf9181d8c1288fc6
https://doi.org/10.22541/au.167877726.69861020/v1
https://doi.org/10.22541/au.167877726.69861020/v1
Autor:
Hemme Hijma, Ingrid Koopmans, Erica Klaassen, Robert Jan Doll, Rob Zuiker, Geert Jan Groeneveld
Publikováno v:
British Journal of Clinical Pharmacology. WILEY
British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology
Aim: We assessed whether total sleep deprivation (TSD) in combination with pain tests yields a reliable method to assess altered pain thresholds, which subsequently may be used to investigate (novel) analgesics in healthy subjects. Methods: This was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c870fe4bea324c7d5f9946f41924fab7
https://hdl.handle.net/1887/3572118
https://hdl.handle.net/1887/3572118
Autor:
Marloes G. J. van Dongen, Marieke de Kam, Leonie van Meer, Erica Klaassen, Bas Goulouze, Matthijs Moerland, Jacobus Burggraaf, Adam F. Cohen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 359:280-289
ISIS 388626 is an antisense sodium-glucose cotransporter 2 (SGLT2) inhibitor designed to treat type 2 diabetes mellitus by induction of glucosuria. ISIS 388626 was demonstrated to be safe and effective in preclinical trails in several species. We und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31a0ae62a667d8ac26a9bb579abca80
https://doi.org/10.1124/jpet.116.233809
https://doi.org/10.1124/jpet.116.233809
Autor:
Daniël, Kleinloog, Marieke, Liem-Moolenaar, Gabriël, Jacobs, Erica, Klaassen, Marieke, de Kam, Ron, Hijman, Joop, van Gerven
Publikováno v:
Journal of psychopharmacology (Oxford, England). 26(10)
Δ⁹-Tetrahydrocannabinol (THC) produces transient psychomimetic effects in healthy volunteers, constituting a pharmacological model for psychosis. The dopaminergic antagonist haloperidol has previously been shown to reduce these effects. This place
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d28b9ddd215c6c1a20332141cd95235
https://pubmed.ncbi.nlm.nih.gov/22596206
https://pubmed.ncbi.nlm.nih.gov/22596206