Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries

Autor: Tom Z. Yuan, Pankaj Garg, Linya Wang, Jordan R. Willis, Eric Kwan, Ana G Lujan Hernandez, Emily Tuscano, Emily N. Sever, Erica Keane, Cinque Soto, Eric M. Mucker, Mallorie E. Fouch, Edgar Davidson, Benjamin J. Doranz, Shweta Kailasan, M. Javad Aman, Haoyang Li, Jay W. Hooper, Erica Ollmann Saphire, James E. Crowe, Qiang Liu, Fumiko Axelrod, Aaron K. Sato

Publikováno v: mAbs, Vol 14, Iss 1 (2022)

Coronavirus disease 2019 (COVID-19) is an evolving global public health crisis in need of therapeutic options. Passive immunization of monoclonal antibodies (mAbs) represents a promising therapeutic strategy capable of conferring immediate protection

Externí odkaz: https://doaj.org/article/b6c1901170674ee7807acd867a09110b

Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer’s disease profile and possible mechanisms of disease protection

Autor: Almeida, Maria Camila, Eger, Sarah J., He, Caroline, Audouard, Morgane, Nikitina, Arina, Glasauer, Stella M.K., Han, Dasol, Mejía-Cupajita, Barbara, Acosta-Uribe, Juliana, Villalba-Moreno, Nelson David, Littau, Jessica Lisa, Elcheikhali, Megan, Rivera, Erica Keane, Carrettiero, Daniel Carneiro, Villegas-Lanau, Carlos Andrés, Sepulveda-Falla, Diego, Lopera, Francisco, Kosik, Kenneth S.

Publikováno v: In Neuron 5 June 2024 112(11):1778-1794

Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol

Autor: Stella M K, Glasauer, Susan K, Goderie, Jennifer N, Rauch, Elmer, Guzman, Morgane, Audouard, Taylor, Bertucci, Shona, Joy, Emma, Rommelfanger, Gabriel, Luna, Erica, Keane-Rivera, Steven, Lotz, Susan, Borden, Aaron M, Armando, Oswald, Quehenberger, Sally, Temple, Kenneth S, Kosik

Publikováno v: Stem Cell Reports. 17:2127-2140

Mutations in the MAPT gene that encodes tau lead to frontotemporal dementia (FTD) with pathology evident in both cerebral neurons and glia. Human cerebral organoids (hCOs) from individuals harboring pathogenic tau mutations can reveal the earliest do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb91791c7ef84ed6213ee73e21fd297a
https://doi.org/10.1016/j.stemcr.2022.07.011

Rapid exploration of the epitope coverage produced by an Ebola survivor to guide the discovery of therapeutic antibody cocktails

Autor: Tom Z. Yuan, Mohammad Javad Aman, Fumiko Takada Axelrod, Erica Keane, Aaron K. Sato, Yasmina N Abdiche, Madeleine Noonan-Shueh, Qiang Liu, Shweta Kailasan, Ana G Lujan Hernandez

Publikováno v: Antibody Therapeutics

Background Development of successful neutralizing antibodies is dependent upon broad epitope coverage to increase the likelihood of achieving therapeutic function. Recent advances in synthetic biology have allowed us to conduct an epitope binning stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1b7602025d45b02896477579bd85bf
https://pubmed.ncbi.nlm.nih.gov/33912793

Precision Proteoform Design for 4R Tau Isoform Selective Templated Aggregation.

Autor: Longhini AP; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA., DuBose A; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, USA., Lobo S; Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, USA., Vijayan V; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, USA., Bai Y; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA.; Photothermal Spectroscopy Corp., Santa Barbara, CA 93101, USA., Rivera EK; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA., Sala-Jarque J; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA., Nikitina A; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA., Carrettiero DC; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA.; Center for Natural and Human Sciences, Federal University of ABC, São Bernardo do Campo, SP, Brazil., Unger M; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA., Sclafani O; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA., Fu V; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA., Vigers M; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, USA., Buee L; Univ. Lille, Inserm, CHU Lille, LilNCog - Lille Neuroscience & Cognition, F-59000 Lille, France.; LabEx DISTALZ, Alzheimer & Tauopathies Team, F-59000 Lille, France., Landrieu I; CNRS EMR9002 - BSI - Integrative Structural Biology F-59000 Lille, France., Shell S; Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, USA., Shea JE; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, USA.; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, F-59000 Lille, France. Department of Physics, University of California, Santa Barbara, Santa Barbara, CA., Han S; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, USA.; Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, USA.; Lead Contacts., Kosik KS; Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.; Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA.; Lead Contacts.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 28. Date of Electronic Publication: 2023 Nov 28.