Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Erica K. Sinner"'
Publikováno v:
ACS Bio & Med Chem Au, Vol 2, Iss 1, Pp 4-10 (2021)
Externí odkaz:
https://doaj.org/article/a6f80892892a41a59bb5a335d44201cf
Publikováno v:
Nature. 602:343-348
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::373fe03a7c44089394481b1a7c12dbd9
https://doi.org/10.1038/s41586-021-04392-4
https://doi.org/10.1038/s41586-021-04392-4
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(34)
Complex carbapenems are important clinical antibiotics used to treat recalcitrant infections. Their biosynthetic gene clusters contain three essential B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc316f8d64969d53ddd12d7c3b7a475f
https://pubmed.ncbi.nlm.nih.gov/35969793
https://pubmed.ncbi.nlm.nih.gov/35969793
Publikováno v:
RSC Chemical Biology. 3:1028-1034
Complex carbapenems are important clinical antibiotics for difficult-to-treat infections. An essential step in the biosyntheses of these natural products is stereospecific methylation at C6 and subsequent alkylations by cobalamin-dependent radical SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8240300f3e04829a206cdfeacc8f7da1
https://doi.org/10.1039/d2cb00113f
https://doi.org/10.1039/d2cb00113f
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Complex carbapenems are important clinical antibiotics used to treat recalcitrant infections. Their biosynthetic gene clusters contain three essential B 12 -dependent radical S -adenosylmethionine (rSAM) enzymes. The majority of characterized enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb4e7e9b7e58aa6b30955bc75f043d59
https://doi.org/10.1073/pnas.2206494119
https://doi.org/10.1073/pnas.2206494119
Autor:
Erica K. Sinner, Craig A. Townsend
Publikováno v:
Methods Enzymol
Methods in Enzymology ISBN: 9780323955577
Methods in Enzymology ISBN: 9780323955577
ThnK and TokK are cobalamin-dependent radical S-adenosylmethionine enzymes that catalyze sequential methylations of a common carbapenem biosynthetic intermediate. ThnK was an early characterized member of the subfamily of cobalamin-dependent radical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8968c8903959563fd58d230863caa10c
https://pubmed.ncbi.nlm.nih.gov/35644176
https://pubmed.ncbi.nlm.nih.gov/35644176
Publikováno v:
ACS Bio Med Chem Au
ACS Bio & Med Chem Au, Vol 2, Iss 1, Pp 4-10 (2021)
ACS Bio & Med Chem Au, Vol 2, Iss 1, Pp 4-10 (2021)
While bioinformatic evidence of cobalamin-dependent radical S-adenosylmethionine (SAM) enzymes has existed since the naming of the radical SAM superfamily in 2001, none were biochemically characterized until 2011. In the past decade, the field has fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fea0660abdfab5b9ef33e170a3053f6
https://pubmed.ncbi.nlm.nih.gov/35341020
https://pubmed.ncbi.nlm.nih.gov/35341020
Cobalamin- or B12-dependent radicalS-adenosylmethionine (SAM) enzymes acting during carbapenem antibiotic biosynthesis carry out radical-mediated methyl transfers that underlie the therapeutic usefulness of these essential medicines. Here we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::380d217b1c08ae0e6acd5055066ae45d
https://doi.org/10.1101/2021.07.10.451909
https://doi.org/10.1101/2021.07.10.451909
Publikováno v:
Nature
Carbapenems are antibiotics of last resort in the clinic. Due to their potency and broad-spectrum activity, they are an important part of the antibiotic arsenal. The vital role of carbapenems is exemplified by Merck’s FDA approval for the use of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98a9509fbc5d3f43330322ea4f2ca48d
https://pubmed.ncbi.nlm.nih.gov/35110734
https://pubmed.ncbi.nlm.nih.gov/35110734
Publikováno v:
Chem Commun (Camb)
Complex carbapenem β-lactam antibiotics contain diverse C6 alkyl substituents constructed by cobalamin-dependent radical SAM enzymes. TokK installs the C6 isopropyl chain found in asparenomycin. Time-course analyses of TokK and its ortholog ThnK, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d43bc7be5daff56f616c5b803be108a
https://doi.org/10.1039/c9cc07197k
https://doi.org/10.1039/c9cc07197k