Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Erica J. Fratz-Berilla"'
Autor:
Erica J. Fratz-Berilla, Casey Kohnhorst, Nicholas Trunfio, Xin Bush, Aron Gyorgypal, Cyrus Agarabi
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e25512- (2024)
Culture pH is a critical process parameter during CHO cell bioreactor operations that is key for proper cell growth, protein production, and maintaining the critical quality attributes of a monoclonal antibody drug substance. The traditional means of
Externí odkaz:
https://doaj.org/article/acbdf2b755b546b48268b58abee6b86f
Autor:
Nicole Azer, Nicholas Trunfio, Erica J. Fratz‐Berilla, Jin Sung Hong, Jackie Cullinan, Talia Faison, Cyrus D. Agarabi, David N. Powers
Publikováno v:
Biotechnology Progress.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::796d122d9431d7ec7d57b7aa6e8409ee
https://doi.org/10.1002/btpr.3347
https://doi.org/10.1002/btpr.3347
Autor:
null Nicole Azer, null Nicholas Trunfio, null Erica J. Fratz‐Berilla, null Jin Sung Hong, null Jackie Cullinan, null Talia Faison, null Cyrus D. Agarabi, null David N. Powers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::901347a56680e707d08894746390c2ac
https://doi.org/10.1002/btpr.3347/v2/response1
https://doi.org/10.1002/btpr.3347/v2/response1
Autor:
Sai Rashmika Velugula-Yellela, Scott Lute, Carl Breuning, Sarah A. Johnson, Julie Wang, Matthew R. Brown, Meng-Jung Chiang, Talia Faison, Sherri Dolan, Kurt Brorson, Erica J. Fratz‐Berilla
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 74:201-212
Capture bioprocessing unit operations were previously shown to clear or kill several log10 of a model mycoplasma Acholeplasma laidlawii in lab-scale spike/removal studies. Here, we confirm this observation with two additional mollicute species releva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e497f409729c1e71fbe18811fb6695
https://doi.org/10.5731/pdajpst.2018.009613
https://doi.org/10.5731/pdajpst.2018.009613
Autor:
Sai Rashmika Velugula-Yellela, Kurt Brorson, Cyrus Agarabi, David N. Powers, Talia Faison, Erica J. Fratz‐Berilla, Casey Kohnhorst
Publikováno v:
Biotechnology and Bioengineering
Mycoplasma contamination events in biomanufacturing facilities can result in loss of production and costly cleanups. Mycoplasma may survive in mammalian cell cultures with only subtle changes to the culture and may penetrate the 0.2 µm filters often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fe4d4b1cb7397cfe00556fd2c793fd
http://europepmc.org/articles/PMC6900124
http://europepmc.org/articles/PMC6900124
Publikováno v:
Journal of Visualized Experiments.
Primary clarification is an essential step in a biomanufacturing process for the initial removal of cells from therapeutic products within the harvested cell culture fluid. While traditional methods like centrifugation or filtration are widely implem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75af46d1aff44c3b43ef096c4a2e2e6
https://doi.org/10.3791/61161
https://doi.org/10.3791/61161
Autor:
Sai Rashmika Velugula-Yellela, David N. Powers, Ryan J. Graham, Nicholas Trunfio, Erica J. Fratz‐Berilla, Adil Mohammad, Cyrus Agarabi, Talia Faison, Casey Kohnhorst, Phillip Angart
Publikováno v:
Biotechnology and Bioengineering
A mycoplasma contamination event in a biomanufacturing facility can result in costly cleanups and potential drug shortages. Mycoplasma may survive in mammalian cell cultures with only subtle changes to the culture and penetrate the standard 0.2‐µm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c901167f2fdf46a3630e46a690b4ffc6
https://pubmed.ncbi.nlm.nih.gov/32436993
https://pubmed.ncbi.nlm.nih.gov/32436993
Autor:
Chikkathur N. Madhavarao, Hamideh Parhiz, Erica J. Fratz‐Berilla, Muhammad Ashraf, Stephanie A. Ketcham
Publikováno v:
Protein Expression and Purification. 140:28-35
Human β-glucuronidase (GUS; EC 3.2.1.31) is a lysosomal enzyme that catalyzes the hydrolysis of β- d -glucuronic acid residues from the non-reducing termini of glycosaminoglycans. Impairment in GUS function leads to the metabolic disorder mucopolys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f05a32e41d80abf6b1da45866c0fae1
https://doi.org/10.1016/j.pep.2017.07.011
https://doi.org/10.1016/j.pep.2017.07.011
Autor:
Yifan Wang, Cyrus Agarabi, Sai Rashmika Velugula-Yellela, Phillip Angart, Seongkyu Yoon, Brittany Chavez, Nicholas Trunfio, Erica J. Fratz‐Berilla, David N. Powers
Publikováno v:
Biotechnology Progress
Real‐time monitoring of cell cultures in bioreactors can enable expedited responses necessary to correct potential batch failure perturbations which may normally go undiscovered until the completion of the batch and result in failure. Currently, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5946e737255120b31136c42da2274166
https://doi.org/10.1002/btpr.2894
https://doi.org/10.1002/btpr.2894
Autor:
Cyrus Agarabi, Erica J. Fratz‐Berilla, David N. Powers, Talia Faison, Casey Kohnhorst, Phillip Angart, Sai Rashmika Velugula-Yellela, Anneliese Faustino
Publikováno v:
Journal of visualized experiments : JoVE. (147)
Monoclonal antibodies (mAbs) are one of the most popular and well-characterized biological products manufactured today. Most commonly produced using Chinese hamster ovary (CHO) cells, culture and process conditions must be optimized to maximize antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4046ef6f480abfe514027fc7e55894ba
https://pubmed.ncbi.nlm.nih.gov/31107445
https://pubmed.ncbi.nlm.nih.gov/31107445