Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Erica J. Beilharz"'
Publikováno v:
Brain Research. 853:163-173
Insulin-like growth factor-1 (IGF-1) has been shown to be neuroprotective when administered centrally following hypoxic-ischemic (HI) brain injury. However, the cerebral distribution and site of action of IGF-1 after intracerebroventricular (i.c.v.)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67bb114d2b8d78ca6e2f1e1faab5f5e
https://doi.org/10.1016/s0006-8993(99)02030-2
https://doi.org/10.1016/s0006-8993(99)02030-2
Autor:
Naomi L. Baker, Arjan Scheepens, Erica J. Beilharz, Vincenzo C. Russo, Chris E. Williams, Bronwyn Connor, Ernest Sirimanne, George A. Werther, Gary Butler, Peter D. Gluckman, Mike Dragunow
Publikováno v:
Molecular Brain Research. 59:119-134
Insulin-like growth factor 1 (IGF-1) is induced after hypoxic-ischemic (HI) brain injury, and therapeutic studies suggest that IGF-1 may restrict delayed neuronal and glial cell loss. We have used a well-characterised rat model of HI injury to extend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e53ddc292706b0e31bf43c5be70c52
https://doi.org/10.1016/s0169-328x(98)00122-3
https://doi.org/10.1016/s0169-328x(98)00122-3
Autor:
Jian Guan, Stephen Hodgkinson, Ke M. Hua, Chris E. Williams, Stephen J. M. Skinner, Peter D. Gluckman, Erica J. Beilharz
Publikováno v:
NeuroReport. 7:632-636
The movement of peptides from CSF into the parenchyma is thought to be slow and diffusion limited. However IGF-I can reduce neuronal loss at distal sites when given centrally 2 h after hypoxic-ischaemic (HI) injury. The present study determined the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e3fd30aeb17dd9085aa8e9da309ba1
https://doi.org/10.1097/00001756-199601310-00061
https://doi.org/10.1097/00001756-199601310-00061
Autor:
K. Singleton, Mike Dragunow, P. Lawlor, Edward W. Mee, Erica J. Beilharz, E. B. Walker, Richard L.M. Faull
Publikováno v:
Scopus-Elsevier
To test the hypothesis that apoptosis is involved in human brain neurodegenerative disorders, we investigated whether DNA fragmentation occurs in Alzheimer's disease (AD). Huntington's disease (HD) and Parkinson's disease, as well as in temporal lobe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17393a9b375e32eabdeae8e9f4f5beba
https://doi.org/10.1097/00001756-199505090-00026
https://doi.org/10.1097/00001756-199505090-00026
Publikováno v:
Molecular Brain Research. 29:1-14
The mechanisms leading to delayed cell death following hypoxic-ischemic injury in the developing brain are unclear. We examined the possible roles of apoptosis and microglial activation in the 21-day-old rat brain following either mild (15 min) or se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b64bce3a2c2b68d3b71680dd69dbe4
https://doi.org/10.1016/0169-328x(94)00217-3
https://doi.org/10.1016/0169-328x(94)00217-3
Autor:
Erica J. Beilharz, Rodrigo Bravo, Ernest Sirimanne, Mike Dragunow, P. Lawlor, Peter Gluckman, Chris E. Williams
Publikováno v:
Molecular Brain Research. 25:19-33
A unilateral hypoxia-ischaemia (HI) 21-day-old rat preparation was used to assess the effects of HI on the expression of the immediate-early gene proteins (IEGPs) c-Fos/FRAs, Fos B, c-Jun, Jun B, Jun D, Krox 20, Krox 24, and on the mRNA for the neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce43bbcb3da45c3c8c9d5185563f3f6
https://doi.org/10.1016/0169-328x(94)90274-7
https://doi.org/10.1016/0169-328x(94)90274-7
Publikováno v:
Neuroscience. 57:319-328
Recent studies show that focal brain injury, cerebral ischaemia, hypoglycaemia and seizures increase the expression of c-fos and brain-derived neurotrophic factor in brain. Here we report that hippocampal focal brain injury transiently induces the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce74e08baa8bb2ee90f5347294a3e1b
https://doi.org/10.1016/0306-4522(93)90065-n
https://doi.org/10.1016/0306-4522(93)90065-n
Autor:
Mike Dragunow, K. Singleton, P. Lawlor, G.A. MacGibbon, Paul E. Hughes, Peter D. Gluckman, Erica J. Beilharz, Deborah Young, Ernest Sirimanne
Publikováno v:
Molecular Brain Research. 18:347-352
Neurons undergoing delayed neuronal death produced by hypoxia-ischaemia (HI) or status epilepticus (SE) showed a massive expression of c-Jun in their nuclei 24 h after the insult. With SE there was also a weaker induction of c-Fos and Jun B in dying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d17028eb151e9605e86083d557691a
https://doi.org/10.1016/0169-328x(93)90101-t
https://doi.org/10.1016/0169-328x(93)90101-t
Autor:
Peter D. Gluckman, N.D. Klempt, M. Klempt, Erica J. Beilharz, Ernest Sirimanne, Mike Dragunow
Publikováno v:
Molecular Brain Research. 18:209-215
Recent studies suggest a role for the insulin-like growth factor (IGF) system in the repair of damaged tissue following hypoxic-ischemic injury in the infant rat brain. We have used a unilateral model of hypoxic-ischemic injury to assess the possible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f920953e31c336aadddb13b8811aafec
https://doi.org/10.1016/0169-328x(93)90191-q
https://doi.org/10.1016/0169-328x(93)90191-q
Publikováno v:
NeuroReport. 4:183-186
Recent studies have shown that MK801, a potent phencyclidine receptor ligand, causes pathomorphological changes in rat cerebrocortical neurones. Here we report that doses of MK801 (1 and 5 mg kg-1) which have been shown to produce pathomorphological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f79e0f812afd1557094ce624591357
https://doi.org/10.1097/00001756-199302000-00017
https://doi.org/10.1097/00001756-199302000-00017