Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Erica I Williams"'
Autor:
Jeffrey J. Lochhead, Erica I. Williams, Elizabeth S. Reddell, Emma Dorn, Patrick T. Ronaldson, Thomas P. Davis
Publikováno v:
Cells, Vol 12, Iss 4, p 645 (2023)
The neurovascular unit (NVU) is an anatomical group of cells that establishes the blood–brain barrier (BBB) and coordinates cerebral blood flow in association with neuronal function. In cerebral gray matter, cellular constituents of the NVU include
Externí odkaz:
https://doaj.org/article/1f52541bf61b4460a59d90affe72ff93
Autor:
Junzhi Yang, Robert D. Betterton, Erica I. Williams, Joshua A. Stanton, Elizabeth S. Reddell, Chidinma E. Ogbonnaya, Emma Dorn, Thomas P. Davis, Jeffrey J. Lochhead, Patrick T. Ronaldson
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 949 (2022)
The consumption of acetaminophen (APAP) can induce neurological changes in human subjects; however, effects of APAP on blood–brain barrier (BBB) integrity are unknown. BBB changes by APAP can have profound consequences for brain delivery of co-admi
Externí odkaz:
https://doaj.org/article/3bb6e64239064ecc9e872abbd242f14f
Autor:
Kelsy L. Nilles, Erica I. Williams, Robert D. Betterton, Thomas P. Davis, Patrick T. Ronaldson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1898 (2022)
Globally, stroke is a leading cause of death and long-term disability. Over the past decades, several efforts have attempted to discover new drugs or repurpose existing therapeutics to promote post-stroke neurological recovery. Preclinical stroke stu
Externí odkaz:
https://doaj.org/article/e1c5b26816644d24ad839ec0b210494c
Publikováno v:
Drug Transporters. :283-317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::312e0afd9e1606f75ab0d5ee044a549c
https://doi.org/10.1002/9781119739883.ch14
https://doi.org/10.1002/9781119739883.ch14
Autor:
Erica I Williams, Robert Betterton, Joshua A Stanton, Jeffrey J Lochhead, Thomas P Davis, Patrick T Ronaldson
Publikováno v:
Stroke. 54
Clinical development of new drugs for ischemic stroke has been challenging. In contrast, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (i.e., statins) are routinely administered to stroke patients because they improve neurological outcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dfb50d08e463d5e4a26622596f1fe6d
https://doi.org/10.1161/str.54.suppl_1.tp205
https://doi.org/10.1161/str.54.suppl_1.tp205
Autor:
Robert Betterton, Erica I Williams, Joshua Stanton, Jeffrey Lochhead, Tom Davis, Patrick Ronaldson
Publikováno v:
Stroke. 54
Objectives: We have shown that transforming growth factor-β (TGF-β)/activin-like kinase 1 (ALK1) signaling at the blood-brain barrier (BBB) can regulate organic anion transporting polypeptide 1a4 (Oatp1a4), a transporter involved in brain uptake of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9835402b64986f28f1a1d810a461cf8d
https://doi.org/10.1161/str.54.suppl_1.tp209
https://doi.org/10.1161/str.54.suppl_1.tp209
Autor:
Joshua Stanton, Erica I Williams, Robert Betterton, Jeffrey Lochhead, Thomas Davis, Patrick Ronaldson
Publikováno v:
Stroke. 54
Purpose: Cationic drugs have often been considered for stroke treatment but their utility is dependent upondelivery across the blood-brain barrier (BBB). This process can involve transporters for cationic substratessuch as organic cation transporters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba37c64474fba09ebc0f14a3ee17a6b
https://doi.org/10.1161/str.54.suppl_1.wp244
https://doi.org/10.1161/str.54.suppl_1.wp244
Autor:
Robert D. Betterton, Erica I. Williams, Kelsy L. Nilles, Thomas P. Davis, Patrick T. Ronaldson
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629253
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38cd85606247e365a7c5aa26b0179eb2
https://doi.org/10.1007/978-1-0716-2926-0_28
https://doi.org/10.1007/978-1-0716-2926-0_28
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 154 (2020)
Ischemic stroke is the 5th leading cause of death in the United States. Despite significant improvements in reperfusion therapies, stroke patients still suffer from debilitating neurocognitive deficits. This indicates an essential need to develop nov
Externí odkaz:
https://doaj.org/article/3aad241a073642c2bc870f754ae5b3f6
Autor:
Joshua A. Stanton, Erica I. Williams, Robert D. Betterton, Thomas P. Davis, Patrick T. Ronaldson
Publikováno v:
Exp Neurol
Drug discovery and development for stroke is challenging as evidenced by few drugs that have advanced beyond a Phase III clinical trial. Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist that has been shown to be neuroprotective in vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843b16248b4630917fa3074de498c326
https://europepmc.org/articles/PMC9620710/
https://europepmc.org/articles/PMC9620710/