Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Erica D. Watson"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
One-carbon metabolism, including the folate cycle, has a crucial role in fetal development though its molecular function is complex and unclear. The hypomorphic Mtrrgt allele is known to disrupt one-carbon metabolism, and thus methyl group availabili
Externí odkaz:
https://doaj.org/article/55df0324c106409e94c7c6bda088b857
Autor:
Georgina E. T. Blake, Xiaohui Zhao, Hong wa Yung, Graham J. Burton, Anne C. Ferguson-Smith, Russell S. Hamilton, Erica D. Watson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Abnormal folate metabolism in mice results in transgenerational epigenetic inheritance of congenital malformations. Here, the authors provide evidence that defective folate metabolism causes germline epigenetic instability and observe multigeneration
Externí odkaz:
https://doaj.org/article/a2b6f87964694b4bad4140b486ce7efe
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Abnormal uptake or metabolism of folate increases risk of human pregnancy complications, though the mechanism is unclear. Here, we explore how defective folate metabolism influences early development by analysing mice with the hypomorphic Mtrrgt muta
Externí odkaz:
https://doaj.org/article/553ff89818d34589bf178f5560e08b38
Autor:
Alice P. Sowton, Nisha Padmanabhan, Simon J. Tunster, Ben D. McNally, Antonio Murgia, Aisha Yusuf, Julian L. Griffin, Andrew J. Murray, Erica D. Watson
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 23, Iss , Pp - (2020)
Nonalcoholic fatty liver disease (NAFLD) is associated with dietary folate deficiency and mutations in genes required for one‑carbon metabolism. However, the mechanism through which this occurs is unclear. To improve our understanding of this link,
Externí odkaz:
https://doaj.org/article/b828d8c6f0654a398e8fa0e34097c012
Publikováno v:
Reproduction. 159:R213-R235
The placenta performs a range of crucial functions that support fetal growth during pregnancy, including facilitating the supply of oxygen and nutrients to the fetus, removal of waste products from the fetus and the endocrine modulation of maternal p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a389b5c143d4a541367cb11239ad6b0
https://doi.org/10.1530/rep-20-0007
https://doi.org/10.1530/rep-20-0007
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Abnormal uptake or metabolism of folate increases risk of human pregnancy complications, though the mechanism is unclear. Here, we explore how defective folate metabolism influences early development by analysing mice with the hypomorphic Mtrr gt mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f99e0d07612bc9b72e29aa0954818f0
Publikováno v:
The Journal of physiologyReferences. 599(17)
Endoplasmic reticulum (ER) stress promotes placental dysmorphogenesis and is associated with poor pregnancy outcomes. We show that unfolded protein response signalling pathways located in the ER drive differentiation of mouse trophoblast stem cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbbd2625ba9de8540e7a1c53ee1f443
https://pubmed.ncbi.nlm.nih.gov/34269420
https://pubmed.ncbi.nlm.nih.gov/34269420
Autor:
Francesca Colleoni, Nisha Padmanabhan, Hong-Wa Yung, Erica D Watson, Irene Cetin, Martha C Tissot van Patot, Graham J Burton, Andrew J Murray
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55194 (2013)
Fetal growth is critically dependent on energy metabolism in the placenta, which drives active exchange of nutrients. Placental oxygen levels are therefore vital, and chronic hypoxia during pregnancy impairs fetal growth. Here we tested the hypothesi
Externí odkaz:
https://doaj.org/article/b91a72c70fb2420d8bb2cd89b845db84
Autor:
Ada M. Krzak, Nisha Padmanabhan, Jens Kieckbusch, Erica D. Watson, Joanna Rakoczy, Tereza Cindrova-Davies
Publikováno v:
Placenta. 59:46-56
Introduction Throughout pregnancy, the placenta dynamically changes as trophoblast progenitors differentiate into mature trophoblast cell subtypes. This process is in part controlled by epigenetic regulation of DNA methylation leading to the inactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65022f6b1e0a896f6803560f329eb3e0
https://doi.org/10.1016/j.placenta.2017.09.008
https://doi.org/10.1016/j.placenta.2017.09.008
Autor:
Colleen Geary Joo, Georgina E T Blake, Malwina Prater, Erica D. Watson, Russell S. Hamilton, Katerina Menelaou, Simon James Tunster, James C. Cross
Publikováno v:
Reproduction (Cambridge, England)
Assisted reproduction technologies (ARTs) are becoming increasingly common. Therefore, how these procedures influence gene regulation and foeto-placental development are important to explore. Here, we assess the effects of blastocyst transfer on mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7472aa618f3e1b230b572121cce42481
https://pubmed.ncbi.nlm.nih.gov/31751309
https://pubmed.ncbi.nlm.nih.gov/31751309