Výsledky vyhledávání - "Erica C, Larson"

Akademický článek

HIV-1 provirus transcription and translation in macrophages differs from pre-integrated cDNA complexes and requires E2F transcriptional programs

Autor: Albebson L. Lim, Philip Moos, Christopher D. Pond, Erica C. Larson, Laura J. Martins, Matthew A. Szaniawski, Vicente Planelles, Louis R. Barrows

Publikováno v: Virulence, Vol 13, Iss 1, Pp 386-413 (2022)

HIV-1 cDNA pre-integration complexes persist for weeks in macrophages and remain transcriptionally active. While previous work has focused on the transcription of HIV-1 genes; our understanding of the cellular milieu that accompanies viral production

Externí odkaz: https://doaj.org/article/d117a10300674c17bc372d36e1db60f3

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Akademický článek

Spontaneous Control of SIV Replication Does Not Prevent T Cell Dysregulation and Bacterial Dissemination in Animals Co-Infected with M. tuberculosis

Autor: Ryan V. Moriarty, Mark A. Rodgers, Amy L. Ellis, Alexis J. Balgeman, Erica C. Larson, Forrest Hopkins, Michael R. Chase, Pauline Maiello, Sarah M. Fortune, Charles A. Scanga, Shelby L. O’Connor

Publikováno v: Microbiology Spectrum, Vol 10, Iss 3 (2022)

ABSTRACT Individuals co-infected with HIV and Mycobacterium tuberculosis (Mtb) are more likely to develop severe tuberculosis (TB) disease than HIV-naive individuals. To understand how a chronic pre-existing Simian immunodeficiency virus (SIV) infect

Externí odkaz: https://doaj.org/article/492e19bcf78a4140bfc2ee5b6a89f818

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Akademický článek

MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection.

Autor: Amy L Ellis, Alexis J Balgeman, Erica C Larson, Mark A Rodgers, Cassaundra Ameel, Tonilynn Baranowski, Nadean Kannal, Pauline Maiello, Jennifer A Juno, Charles A Scanga, Shelby L O'Connor

Publikováno v: PLoS Pathogens, Vol 16, Iss 5, p e1008585 (2020)

Mucosal-associated invariant T (MAIT) cells can recognize and respond to some bacterially infected cells. Several in vitro and in vivo models of Mycobacterium tuberculosis (Mtb) infection suggest that MAIT cells can contribute to control of Mtb, but

Externí odkaz: https://doaj.org/article/da336923d11e4271be30be209e0ba75c

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Akademický článek

Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase.

Autor: Erica C Larson, Albebson L Lim, Christopher D Pond, Matthew Craft, Mirela Čavužić, Grover L Waldrop, Eric W Schmidt, Louis R Barrows

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0233485 (2020)

Antimicrobial resistance is a growing global health and economic concern. Current antimicrobial agents are becoming less effective against common bacterial infections. We previously identified pyrrolocins A and C, which showed activity against a vari

Externí odkaz: https://doaj.org/article/61a42a47bae64743abf8d6027c3f20a5

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Host Immunity to Mycobacterium tuberculosis Infection Is Similar in Simian Immunodeficiency Virus (SIV)-Infected, Antiretroviral Therapy-Treated and SIV-Naïve Juvenile Macaques

Publikováno v: Infection and Immunity. 91

Pre-existing HIV infection increases tuberculosis (TB) risk in children. Antiretroviral therapy (ART) reduces, but does not abolish, this risk in children with HIV.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::172adcaad3e8215a412007bdcdad27f3
https://doi.org/10.1128/iai.00558-22

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Host Immunity toMycobacterium tuberculosisInfection is Similar in Simian Immunodeficiency Virus (SIV)-infected, Antiretroviral Therapy-treated and SIV-naïve Juvenile Macaques

Pre-existing HIV infection increases tuberculosis (TB) risk in children. Antiretroviral therapy (ART) reduces, but does not abolish, this risk in children with HIV. The immunologic mechanisms involved in TB progression in both HIV-naïve and HIV-infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::741f374e2e2ee5f6f6b5e43dc6310405
https://doi.org/10.1101/2022.12.14.520525

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Pre-existing Simian Immunodeficiency Virus Infection Increases Expression of T Cell Markers Associated with Activation during Early Mycobacterium tuberculosis Coinfection and Impairs TNF Responses in Granulomas

Autor: Pauline Maiello, Chelsea M Causgrove, Cassaundra Ameel, Jaime A Tomko, Alexis J. Balgeman, Tonilynn M Baranowski, Ryan V. Moriarty, Charles A. Scanga, Erica C. Larson, Amy L. Ellis-Connell, Mark Rodgers, Shelby L. O’Connor

Publikováno v: The Journal of Immunology. 207:175-188

Tuberculosis (TB) is the leading infectious cause of death among people living with HIV. People living with HIV are more susceptible to contracting Mycobacterium tuberculosis and often have worsened TB disease. Understanding the immunologic defects c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a460db9957cceb93b64fc701681cc0c
https://doi.org/10.4049/jimmunol.2100073

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Akademický článek

Mycobacterium tuberculosis reactivates latent HIV-1 in T cells in vitro.

Autor: Erica C Larson, Camille L Novis, Laura J Martins, Amanda B Macedo, Kadyn E Kimball, Alberto Bosque, Vicente Planelles, Louis R Barrows

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0185162 (2017)

Following proviral integration into the host cell genome and establishment of a latent state, the human immunodeficiency virus type 1 (HIV-1) can reenter a productive life cycle in response to various stimuli. HIV-1 reactivation occurs when transcrip

Externí odkaz: https://doaj.org/article/a2e8dc7a41ce4fd4a5543da80b0e0f14

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