Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Erica A. Pyles"'
Autor:
Sophia Liu, Yuetian Yan, Cody M. Secor, Zachary R. Oberholtzer, Donna J. Skow, Mushhood Sheikh, Youmi Moon, Yue Fu, Cristinel Sandu, Shunhai Wang, Ning Li, Jennifer B. Nguyen, Michael P. Rosconi, Erica A. Pyles
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTCo-formulation of multiple drug products is an efficient and convenient approach to simultaneously deliver multiple biotherapeutics with the potentially added benefit of a synergistic therapeutic effect. However, co-formulation also increases
Externí odkaz:
https://doaj.org/article/1494bc863c804d3eb9523d2ed2f12fcb
Autor:
Dharia Sara Silas, Bindiya Juneja, Keerat Kaur, Muralikrishna Narayanareddy Gari, Yingjian You, Youmi Moon, Yizhuo Chen, Srishti Arora, Johanna Hansen, Kathir Muthusamy, Yue Fu, Nisha Palackal, Erica A. Pyles
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1227 (2024)
Background: In vitro-transcribed (IVT) mRNA has been established as a promising platform for therapeutics and vaccine development. Double-stranded RNA (dsRNA) is a major impurity of IVT mRNA and can trigger unfavored immune responses, potentially cau
Externí odkaz:
https://doaj.org/article/3c9a6241abe84136aea0e57880826076
Autor:
Xiaobin Xu, Aming Zhang, Yingjie Xu, Yuan Cao, Stephen Cale, Matthew Franklin, Prasad Sarangapani, Peter M. Ihnat, Haibo Qiu, Dingjiang Liu, Erica A. Pyles, Mohammed Shameem, Ning Li
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1335-1345
High concentration formulations of therapeutic monoclonal antibodies (mAbs) are highly desired for subcutaneous injection. However, high concentration formulations can exhibit unusual molecular behaviors, such as high viscosity or aggregation, that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5df5011bc0d9950e5e4b7d3f135ef7
https://doi.org/10.1016/j.xphs.2021.12.027
https://doi.org/10.1016/j.xphs.2021.12.027
Publikováno v:
Journal of pharmaceutical sciences. 111(11)
Over seventy percent of marketed monoclonal antibody therapeutics contain between 0.001% and 0.1% (w/v) polysorbate, as it has a generally beneficial stabilizing effect that increases drug product shelf life. However, polysorbate has also been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddce91116d6d6fa60350a27a7a12aa1c
https://pubmed.ncbi.nlm.nih.gov/35977591
https://pubmed.ncbi.nlm.nih.gov/35977591
Autor:
Zhijie Wu, Hongxia Wang, Jikang Wu, Yu Huang, Xueqing Zhao, Jennifer B. Nguyen, Michael P. Rosconi, Erica A. Pyles, Haibo Qiu, Ning Li
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 223:115147
Therapeutic antibodies are a major class of pharmaceutical drugs used to treat a wide variety of diseases. They have several advantages including the high specificity and binding affinity to their molecular targets, and generally low immunotoxicity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ce0ee8f42d9e9bf330a7323651028e
https://doi.org/10.1016/j.jpba.2022.115147
https://doi.org/10.1016/j.jpba.2022.115147
Publikováno v:
Biochemistry. 37:5194-5200
I nEscherichia coli, the cyclic AMP receptor protein (CRP) serves as a sensor of the intracellular level of cyclic AMP. At increasing concentrations of cyclic AMP, CRP becomes activated upon binding a cyclic AMP molecule. The activated CRP is capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4c68d745e0660ce014b369736afbeb
https://doi.org/10.1021/bi972450i
https://doi.org/10.1021/bi972450i
Autor:
J. Ching Lee, Erica A. Pyles
Publikováno v:
Biochemistry. 37:5201-5210
The effect of DNA sequence variability and the degree of cyclic AMP receptor protein (CRP)-induced bending of the flanking ends of fluorescently labeled DNA were investigated by steady-state fluorescence and differential phase polarization studies in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea72d1493f45f30ea196796c1630cea8
https://doi.org/10.1021/bi972451a
https://doi.org/10.1021/bi972451a
Autor:
Erica A. Pyles, Susan Bane Hastie
Publikováno v:
The Journal of Organic Chemistry. 58:2751-2759
A dinitrophenyl substituent at the C-7 position of N-deacetylcolchicine and N-deacetylisocolchicine was shown to perturb the 1 H NMR and circular dichroic spectra of colchicinoid ring systems. The perturbations were explained by an interaction betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd8aebf158e9592631789e5684c1423d
https://doi.org/10.1021/jo00062a016
https://doi.org/10.1021/jo00062a016
Publikováno v:
Biochemistry. 31:2034-2039
Near-ultraviolet absorption and circular dichroic spectra of several B-ring derivatives of colchicine have been obtained in a variety of solvents. The spectra of the molecules in solvent were analyzed and compared with spectra of the molecules bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e520005c82818eb14a62523f99a0cd
https://doi.org/10.1021/bi00122a020
https://doi.org/10.1021/bi00122a020
Autor:
Erica A. Pyles, Susan Bane Hastie
Publikováno v:
Biochemistry. 32(9)
The kinetics of four B-ring derivatives of colchicine binding to tubulin has been examined quantitatively. The bindings of deacetamidocolchicine, deacetylcolchicine, demecolcine, and N-methyl- demecolcine to tubulin were biphasic processes. The assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7243be6df9e697914e0b5a5bd4834ca0
https://pubmed.ncbi.nlm.nih.gov/8443174
https://pubmed.ncbi.nlm.nih.gov/8443174