Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Erica A. Pyles"'
Autor:
Sophia Liu, Yuetian Yan, Cody M. Secor, Zachary R. Oberholtzer, Donna J. Skow, Mushhood Sheikh, Youmi Moon, Yue Fu, Cristinel Sandu, Shunhai Wang, Ning Li, Jennifer B. Nguyen, Michael P. Rosconi, Erica A. Pyles
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTCo-formulation of multiple drug products is an efficient and convenient approach to simultaneously deliver multiple biotherapeutics with the potentially added benefit of a synergistic therapeutic effect. However, co-formulation also increases
Externí odkaz:
https://doaj.org/article/1494bc863c804d3eb9523d2ed2f12fcb
Autor:
Xiaobin Xu, Aming Zhang, Yingjie Xu, Yuan Cao, Stephen Cale, Matthew Franklin, Prasad Sarangapani, Peter M. Ihnat, Haibo Qiu, Dingjiang Liu, Erica A. Pyles, Mohammed Shameem, Ning Li
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1335-1345
High concentration formulations of therapeutic monoclonal antibodies (mAbs) are highly desired for subcutaneous injection. However, high concentration formulations can exhibit unusual molecular behaviors, such as high viscosity or aggregation, that p
Autor:
Zhijie Wu, Hongxia Wang, Jikang Wu, Yu Huang, Xueqing Zhao, Jennifer B. Nguyen, Michael P. Rosconi, Erica A. Pyles, Haibo Qiu, Ning Li
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 223:115147
Therapeutic antibodies are a major class of pharmaceutical drugs used to treat a wide variety of diseases. They have several advantages including the high specificity and binding affinity to their molecular targets, and generally low immunotoxicity a
Publikováno v:
Journal of pharmaceutical sciences. 111(11)
Over seventy percent of marketed monoclonal antibody therapeutics contain between 0.001% and 0.1% (w/v) polysorbate, as it has a generally beneficial stabilizing effect that increases drug product shelf life. However, polysorbate has also been shown
Publikováno v:
Biochemistry. 37:5194-5200
I nEscherichia coli, the cyclic AMP receptor protein (CRP) serves as a sensor of the intracellular level of cyclic AMP. At increasing concentrations of cyclic AMP, CRP becomes activated upon binding a cyclic AMP molecule. The activated CRP is capable
Autor:
J. Ching Lee, Erica A. Pyles
Publikováno v:
Biochemistry. 37:5201-5210
The effect of DNA sequence variability and the degree of cyclic AMP receptor protein (CRP)-induced bending of the flanking ends of fluorescently labeled DNA were investigated by steady-state fluorescence and differential phase polarization studies in
Autor:
Erica A. Pyles, James Lee
Publikováno v:
Biochemistry. 35:1162-1172
Escherichia coli cAMP receptor protein (CRP) controls more than 20 genes. There are significant differences in the promoter regions in these genes. Thus, an elucidation of the mechanism of CRP action requires knowledge about the mode of selectivity i
Autor:
Erica A. Pyles, Susan Bane Hastie
Publikováno v:
The Journal of Organic Chemistry. 58:2751-2759
A dinitrophenyl substituent at the C-7 position of N-deacetylcolchicine and N-deacetylisocolchicine was shown to perturb the 1 H NMR and circular dichroic spectra of colchicinoid ring systems. The perturbations were explained by an interaction betwee
Autor:
Erica A. Pyles, Susan Bane Hastie
Publikováno v:
Biochemistry. 31:7086-7093
Fluorescence spectra of several B-ring derivatives of allocolchicine in a variety of solvents have been obtained. The quantum yields of the allocolchicine derivatives decreased with amine substitution at the C-7 position (R = H > NH2 >> NHCH3 > N(CH3
Publikováno v:
Biochemistry. 31:2034-2039
Near-ultraviolet absorption and circular dichroic spectra of several B-ring derivatives of colchicine have been obtained in a variety of solvents. The spectra of the molecules in solvent were analyzed and compared with spectra of the molecules bound