Výsledky vyhledávání - "Erica A, Fradinger"

Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system

Autor: Hayden Schmidt, Zoran Radić, Erica A. Fradinger, Palmer Taylor

Publikováno v: Toxicology and Applied Pharmacology. 284:197-203

The zebrafish is rapidly becoming an important model system for screening of new therapeutics. Here we evaluated the zebrafish as a potential pharmacological model for screening novel oxime antidotes to organophosphate (OP)-inhibited acetylcholineste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e55ded9a4303a6737d78902a42c814d
https://doi.org/10.1016/j.taap.2015.02.011

Zobrazit plný text záznamu

Organophosphate pesticides induce morphological abnormalities and decrease locomotor activity and heart rate inDanio rerioandXenopus laevis

Autor: Zackery K. Turman, Jonathan Gregg, Fiona L. Watson, Joseph M. Tilghman, Natalie Hole, Hayden Schmidt, Hena Garcia, Erica A. Fradinger

Publikováno v: Environmental Toxicology and Chemistry. 33:1337-1345

Organophosphate pesticides (OPs), a class of acetylcholinesterase inhibitors, are used widely in agriculture to reduce insect populations. Because of the conservation of acetylcholinesterase between invertebrates and vertebrates, OPs also can adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b0abd2def5bb4a8117bf034247f220b
https://doi.org/10.1002/etc.2559

Zobrazit plný text záznamu

The functional group on (E)-4,4′–disubstituted stilbenes influences toxicity and antioxidative activity in differentiated PC-12 cells

Autor: Ralph Isovitsch, Michael Galbreath, Erica A. Fradinger, Cameron R. Pye, Sean W. Larsen, Genevieve X. Garcia

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:6355-6359

This work probes the relationship between stilbene functional group and biological activity. The biological activity of synthesized stilbenes (E)-4,4'-dicyanostilbene, (E)-4,4'-diacetylstilbene, (E)-4,4'-diaminostilbene, a novel stilbene, 1,1'-(vinyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644d06a1a999a0d56d78a10ef37600b7
https://doi.org/10.1016/j.bmcl.2013.09.073

Zobrazit plný text záznamu

Mechanistic Investigation of the Inhibition of Aβ42 Assembly and Neurotoxicity by Aβ42 C-Terminal Fragments

Autor: George B. Benedek, Miao Tan, Aleksey Lomakin, Brigita Urbanc, Bernhard H. Monien, Sean M. Spring, Erica A. Fradinger, Huiyuan Li, Reeve Zemel, Gal Bitan, Cui-Wei Xie

Publikováno v: Biochemistry. 49:6358-6364

Oligomeric forms of amyloid beta-protein (Abeta) are key neurotoxins in Alzheimer's disease (AD). Previously, we found that C-terminal fragments (CTFs) of Abeta42 interfered with assembly of full-length Abeta42 and inhibited Abeta42-induced toxicity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54010b6622630236f6d5c082659d3ef1
https://doi.org/10.1021/bi100773g

Zobrazit plný text záznamu

Biophysical Characterization of Aβ42 C-Terminal Fragments: Inhibitors of Aβ42 Neurotoxicity

Autor: Brigita Urbanc, Huiyuan Li, Gal Bitan, Erica A. Fradinger, Bernhard H. Monien

Publikováno v: Biochemistry. 49:1259-1267

A key event in Alzheimer's disease (AD) is age-dependent, brain accumulation of amyloid beta-protein (Abeta) leading to Abeta self-association into neurotoxic oligomers. Previously, we showed that Abeta oligomerization and neurotoxicity could be inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6187bc2732c30f0442b95988f374bc
https://doi.org/10.1021/bi902075h

Zobrazit plný text záznamu

Role of Two Genes Encoding PACAP in Early Brain Development in Zebrafish

Autor: Sheng Wu, Erica A. Fradinger, Nancy M. Sherwood, Bruce A. Adams

Publikováno v: Annals of the New York Academy of Sciences. 1070:602-621

To study the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in early brain development, we examined PACAP and its receptors for first expression and then separately knocked down the two forms of PACAP in zebrafish where developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f4ed6558c6b08f5a2e48a6695d4925
https://doi.org/10.1196/annals.1317.091

Zobrazit plný text záznamu

Plný text ve formátu HTML

Characterization of four receptor cDNAs: PAC1, VPAC1, a novel PAC1 and a partial GHRH in zebrafish

Autor: Javier Tello, Nancy M. Sherwood, Jean Rivier, Erica A. Fradinger

Publikováno v: Molecular and Cellular Endocrinology. 231:49-63

To understand the role of growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase-activating polypeptide (PACAP) and to examine the functional significance of the co-expression of GHRH and PACAP in fish, their receptors were character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a360bcc1b9398e3e9cd45ddb39eeeb77
https://doi.org/10.1016/j.mce.2004.12.002

Zobrazit plný text záznamu

Developmental changes in the expression of growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide in zebrafish

Autor: Erica A. Fradinger, Sandra L. Krueckl, Nancy M. Sherwood

Publikováno v: The Journal of Comparative Neurology. 455:396-405

Growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase-activating polypeptide (PACAP) are structurally and functionally related members of the glucagon superfamily, a group of hormones important in development, growth, and metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776e6285e5fa56a6ba68ba2831c91f76
https://doi.org/10.1002/cne.10494

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání