A systems biology analysis of reproductive toxicity effects induced by multigenerational exposure to ionizing radiation in C. elegans

Autor: Rémi Guédon, Erica Maremonti, Olivier Armant, Simon Galas, Dag Anders Brede, Catherine Lecomte-Pradines

Publikováno v: Ecotoxicology and Environmental Safety, Vol 225, Iss , Pp 112793- (2021)

Understanding the effects of chronic exposure to pollutants over generations is of primary importance for the protection of humans and the environment; however, to date, knowledge on the molecular mechanisms underlying multigenerational adverse effec

Externí odkaz: https://doaj.org/article/c17fe4b09cd14ba29e5b3c2b2b04d2e2

Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network

Autor: Knut Erik Tollefsen, Frédéric Alonzo, Nicholas A. Beresford, Dag Anders Brede, Elizabeth Dufourcq-Sekatcheff, Rodolphe Gilbin, Nele Horemans, Selma Hurem, Patrick Laloi, Erica Maremonti, Deborah Oughton, Olivier Simon, You Song, Michael D. Wood, Li Xie, Sandrine Frelon

Publikováno v: International Journal of Radiation Biology
International Journal of Radiation Biology, 2022, 98 (12), pp.1816-1831. ⟨10.1080/09553002.2022.2110317⟩

International audience; Background: Reproductive effects of ionizing radiation in organisms have been observed under laboratory and field conditions. Such assessments often rely on associations between exposure and effects, and thus lacking a detaile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60681781615372012a1118c859d184a
https://doi.org/10.1080/09553002.2022.2110317

Adaptive tolerance to multigenerational silver nanoparticle (NM300K) exposure by the nematode Caenorhabditis elegans is associated with increased sensitivity to AgNO3

Autor: Dag Anders Brede, Erica Maremonti, Lisa M. Rossbach, Deborah Oughton, Dag M. Eide

Publikováno v: Nanotoxicology. 13:527-542

Toxic effects of silver nanoparticles (Ag NPs) are, in most cases, measured within a single generation, while information regarding multigenerational exposure remains scarce. The current study asse...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f817feef44e8566d4890f510fdc06c3b
https://doi.org/10.1080/17435390.2018.1557272

Ionizing radiation, genotoxic stress, and mitochondrial DNA copy-number variation in Caenorhabditis elegans: droplet digital PCR analysis

Autor: Erica Maremonti, Einar Sverre Berg, Dag Markus Eide, Ann-Karin Olsen, Dag Anders Brede

Publikováno v: Mutation Research. Genetic Toxicology and Environmental Mutagenesis

Mitochondria are vulnerable to the effects of ionizing radiation; damage to mitochondrial DNA (mtDNA) may be more extensive and persistent than damage to nuclear DNA (nDNA). Variation in mtDNA copy number has been proposed as a marker for mitochondri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3eb560e2e474d97a5e586b3bb59e07
https://hdl.handle.net/11250/2823361

Adaptive tolerance to multigenerational silver nanoparticle (NM300K) exposure by the nematode

Autor: Lisa M, Rossbach, Erica, Maremonti, Dag M, Eide, Deborah H, Oughton, Dag A, Brede

Publikováno v: Nanotoxicology. 13(4)

Toxic effects of silver nanoparticles (Ag NPs) are, in most cases, measured within a single generation, while information regarding multigenerational exposure remains scarce. The current study assessed changes in toxic response (reproduction, fertili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba401554684cd610dafbc25d906f824f
https://pubmed.ncbi.nlm.nih.gov/30773089