Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Erica, Ballabio"'
Autor:
Nicholas T. Crump, Erica Ballabio, Laura Godfrey, Ross Thorne, Emmanouela Repapi, Jon Kerry, Marta Tapia, Peng Hua, Christoffer Lagerholm, Panagis Filippakopoulos, James O. J. Davies, Thomas A. Milne
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The role of BRD4 and Mediator in regulating enhancer-promoter interactions is poorly understood. Here the authors find that treatment with BET inhibitors or pharmacological degradation of BRD4 disrupts transcription while having very little effect on
Externí odkaz:
https://doaj.org/article/8fdcc190846d423ba9cdaa4d7f3a1b96
Autor:
Akihiko Numata, Hui Si Kwok, Akira Kawasaki, Jia Li, Qi-Ling Zhou, Jon Kerry, Touati Benoukraf, Deepak Bararia, Feng Li, Erica Ballabio, Marta Tapia, Aniruddha J. Deshpande, Robert S. Welner, Ruud Delwel, Henry Yang, Thomas A. Milne, Reshma Taneja, Daniel G. Tenen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Gene fusions involving MLL and different partner genes define unique subgroups of acute myelogenous leukemia, but the mechanisms underlying specific subgroups are not fully clear. Here the authors elucidate the mechanisms of MLL-AF6 induced transform
Externí odkaz:
https://doaj.org/article/9dfa107dbcde4625a8ba0c6b7e56e898
Autor:
Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P. Blackledge, Helen Ma, Erica Ballabio, Sorcha O’Byrne, Frida Ponthan, Olaf Heidenreich, Anindita Roy, Irene Roberts, Marina Konopleva, Robert J. Klose, Huimin Geng, Thomas A. Milne
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 482-495 (2017)
Summary: Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic pat
Externí odkaz:
https://doaj.org/article/3df8a0179df148b1b74368a6dccf96bb
Autor:
Juliana M. Benito, Laura Godfrey, Kensuke Kojima, Leah Hogdal, Mark Wunderlich, Huimin Geng, Isabel Marzo, Karine G. Harutyunyan, Leonard Golfman, Phillip North, Jon Kerry, Erica Ballabio, Triona Ní Chonghaile, Oscar Gonzalo, Yihua Qiu, Irmela Jeremias, LaKiesha Debose, Eric O’Brien, Helen Ma, Ping Zhou, Rodrigo Jacamo, Eugene Park, Kevin R. Coombes, Nianxiang Zhang, Deborah A. Thomas, Susan O’Brien, Hagop M. Kantarjian, Joel D. Leverson, Steven M. Kornblau, Michael Andreeff, Markus Müschen, Patrick A. Zweidler-McKay, James C. Mulloy, Anthony Letai, Thomas A. Milne, Marina Konopleva
Publikováno v:
Cell Reports, Vol 13, Iss 12, Pp 2715-2727 (2015)
Targeted therapies designed to exploit specific molecular pathways in aggressive cancers are an exciting area of current research. Mixed Lineage Leukemia (MLL) mutations such as the t(4;11) translocation cause aggressive leukemias that are refractory
Externí odkaz:
https://doaj.org/article/c1a105f3ea7b4ced908a81b1bad07bcd
Autor:
Adam C. Wilkinson, Erica Ballabio, Huimin Geng, Phillip North, Marta Tapia, Jon Kerry, Debabrata Biswas, Robert G. Roeder, C. David Allis, Ari Melnick, Marella F.T.R. de Bruijn, Thomas A. Milne
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 116-127 (2013)
The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans.
Externí odkaz:
https://doaj.org/article/afba6d9af8554e5ea61f17f6abc128fe
Autor:
Christian Hurtz, Lai N. Chan, Scott A. Armstrong, Jianjun Chen, Erica Ballabio, Huimin Geng, Thomas A. Milne, Gauri Deb, Patricia Ernst, Ari Melnick, Haytham Khoury, Chun-Wei Chen, Gang Xiao, Markus Müschen
Publikováno v:
Genes & Development. 33:1265-1279
Chromosomal rearrangements of the mixed lineage leukemia (MLL) gene occur in ∼10% of B-cell acute lymphoblastic leukemia (B-ALL) and define a group of patients with dismal outcomes. Immunohistochemical staining of bone marrow biopsies from most of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f3c9bbe920aa2643c31bff1cf10062
https://doi.org/10.1101/gad.327593.119
https://doi.org/10.1101/gad.327593.119
Autor:
Emmanouela Repapi, Panagis Filippakopoulos, Erica Ballabio, Christoffer Lagerholm, Peng Hua, Jon Kerry, Thomas A. Milne, Nicholas T. Crump, Laura Godfrey, Marta Tapia, James O.J. Davies, Ross Thorne
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Enhancers are DNA sequences that enable complex temporal and tissue-specific regulation of genes in higher eukaryotes. Although it is not entirely clear how enhancer-promoter interactions can increase gene expression, this proximity has been observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911d87e3a31d6657c7578744a95c3c3b
https://doi.org/10.1038/s41467-020-20400-z
https://doi.org/10.1038/s41467-020-20400-z
Autor:
Erica Ballabio, Regina Regan, Elisa Garimberti, Jochen Harbott, Jutta Bradtke, Andrea Teigler-Schlegel, Andrea Biondi, Giovanni Cazzaniga, Giovanni Giudici, James S Wainscoat, Jacqueline Boultwood, Joanna M Bridger, Samantha J L Knight, Sabrina Tosi
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20607 (2011)
Leukaemia is often associated with genetic alterations such as translocations, amplifications and deletions, and recurrent chromosome abnormalities are used as markers of diagnostic and prognostic relevance. However, a proportion of acute myeloid leu
Externí odkaz:
https://doaj.org/article/20d196a998a84cfb97abb260fc0fc215
Autor:
Teresa Marafioti, Jennifer C. Paterson, Erica Ballabio, Andreas Chott, Yasodha Natkunam, Manuel Rodriguez-Justo, Anne Plonquet, Socorro M. Rodriguez-Pinilla, Wolfram Klapper, Martin-L. Hansmann, Stefano A. Pileri, Peter G. Isaacson, Harald Stein, Miguel A. Piris, David Y. Mason, Philippe Gaulard
Publikováno v:
Haematologica, Vol 95, Iss 3 (2010)
Background T follicular helper (TFH) cells reside in the light zone of germinal centers and are considered the cell of origin of angioimmunoblastic T-cell lymphoma. Recently, CXCL13, PD-1 and SAP were described as useful markers for TFH cells and ang
Externí odkaz:
https://doaj.org/article/8c565518df4f40909ad2730781b5ab21
Autor:
Giovanna Roncador, José-Francisco García Verdes-Montenegro, Sara Tedoldi, Jennifer C. Paterson, Wolfram Klapper, Erica Ballabio, Lorena Maestre, Stefano Pileri, Martin-Leo Hansmann, Miguel A. Piris, David Y. Mason, Teresa Marafioti
Publikováno v:
Haematologica, Vol 92, Iss 8 (2007)
Background and Objectives In the present paper we report that SAP, an intracytoplasmic molecule that is involved in cell signaling, is an immunohistologic marker for germinal center T cells in paraffin-embedded tissue. We document its expression, and
Externí odkaz:
https://doaj.org/article/e4f7520ecc674a0dbace9c98afb01cd1