Cdx1andCdx2have overlapping functions in anteroposterior patterning and posterior axis elongation

Autor: Kallayanee Chawengsaksophak, Barbara I. Meyer, Eric van den Akker, Wim de Graaff, Jacqueline Deschamps, Sylvie Forlani, Felix Beck

Publikováno v: Development. 129:2181-2193

Mouse Cdx and Hox genes presumably evolved from genes on a common ancestor cluster involved in anteroposterior patterning. Drosophila caudal (cad) is involved in specifying the posterior end of the early embryo, and is essential for patterning tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f611ac00fb715552801ce612f142801
https://doi.org/10.1242/dev.129.9.2181

Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice

Autor: Dick Jaarsma, Jan C. Holstege, Eric van den Akker, Wim de Graaff, Sebastian Cardona Cano, Mehdi Hossaini, J. Deschamps

Publikováno v: Proceedings of the National Academy of Sciences of the U.S.A., 105(17), 6338-6343. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 105(17), 6338-6343. National Academy of Sciences

Although Hox gene expression has been linked to motoneuron identity, a role of these genes in development of the spinal sensory system remained undocumented. Hoxb genes are expressed at high levels in the dorsal horn of the spinal cord. Hoxb8 null mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f863af2f4901c521c7a869273a36d7
https://pure.eur.nl/en/publications/377e9cab-f9fb-4309-b68f-39bd518bb5d2

Diagnostic DHPLC Quality Assurance (DDQA): a collaborative approach to the generation of validated and standardized methods for DHPLC-based mutation screening in clinical genetics laboratories

Autor: Geneviève Michils, Stephan Schrooten, Bruno Vankeirsbilck, Zandra Clark, Shirley McQuaid, Elisabeth Dequeker, Gert Matthijs, Harvey Js, Els Schollen, Eric van den Akker, Ron van Schooten

Publikováno v: Human mutation. 25(6)

Genetic testing in a clinical diagnostic environment must be subject to rigorous quality control procedures, in order to ensure consistency and accuracy of results. Denaturing high performance liquid chromatography (DHPLC) has become a standard presc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d8b9eb7409d64243c17b9bdadf313f
https://pubmed.ncbi.nlm.nih.gov/15880509

Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes

Autor: Jeroen Korving, Jacqueline Deschamps, Mark Reijnen, Eric van den Akker, Antje Brouwer, Frits Meijlink

Publikováno v: Mechanisms of development. 89(1-2)

Hoxb8 mutant mice were generated by inserting the lacZ coding sequence in frame with the first exon of Hoxb8. These mice express a fusion protein with a functional β-galactosidase activity instead of Hoxb8. Mutant embryos were analyzed for anatomica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12498d08c8aeaeddc43a367cd374c1b1
https://pubmed.ncbi.nlm.nih.gov/10559485

C/G to A/T transversions represent the main type of mutation induced by gamma-irradiation in double-stranded M13mp10 DNA in a nitrogen-saturated solution

Autor: Eric van den Akker, M. Vincent M. Lafleur, Jacqueline E.F. Braun, A.Handayani Wanamarta, J. Retèl

Publikováno v: Mutation research. 289(2)

To get more insight into the possible mutagenic consequences of DNA damage induced by radiation-generated H radicals (.H), a nitrogen-saturated solution of double-stranded (ds) M13mp10 DNA in phosphate buffer was irradiated with gamma-rays. Under the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5097815dfd5a4f0887c08510eda3ab77
https://pubmed.ncbi.nlm.nih.gov/7690894