Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eric Y. Hu"'
Autor:
Sushmita L Allam, Jean-Marie C Bouteiller, Eric Y Hu, Nicolas Ambert, Renaud Greget, Serge Bischoff, Michel Baudry, Theodore W Berger
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140333 (2015)
Glutamatergic synapses are the most prevalent functional elements of information processing in the brain. Changes in pre-synaptic activity and in the function of various post-synaptic elements contribute to generate a large variety of synaptic respon
Externí odkaz:
https://doaj.org/article/91c6ae112398461bb33fce83b967d63f
Publikováno v:
EMBC
The molecular mechanisms underlying Alzheimer’s disease (AD) have been and are still under heavy scrutiny to better understand what leads to the onset and progression of the disease, and to design and develop efficacious therapeutic strategies. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279114bd9a96ea881fe45030c6a68b1f
https://pubmed.ncbi.nlm.nih.gov/31946282
https://pubmed.ncbi.nlm.nih.gov/31946282
Autor:
Dong Song, Theodore W. Berger, Clayton S. Bingham, Eric Y. Hu, Adam Mergenthal, Jean-Marie C. Bouteiller
Publikováno v:
Frontiers in Computational Neuroscience, Vol 12 (2018)
Frontiers in Computational Neuroscience
Frontiers in Computational Neuroscience
In synapses, calcium is required for modulating synaptic transmission, plasticity, synaptogenesis, and synaptic pruning. The regulation of calcium dynamics within neurons involves cellular mechanisms such as synaptically activated channels and pumps,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f13fdad1eb691424036cde5f3bb3e6
https://doi.org/10.3389/fncom.2018.00058
https://doi.org/10.3389/fncom.2018.00058
Publikováno v:
EMBC
Synapses are key components in signal transmission in the brain, often exhibiting complex non-linear dynamics. Yet, they are often crudely modelled as linear exponential equations in large-scale neuron network simulations. Mechanistic models that use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092af128dae68a316a10e5f32a4b3b3e
https://doi.org/10.1109/embc.2018.8513616
https://doi.org/10.1109/embc.2018.8513616
Publikováno v:
EMBC
Postsynaptic calcium dynamics play a critical role in synaptic plasticity, but are often difficult to measure in experimental protocols due to their relatively fast rise and decay times, and the small spine dimensions. To circumvent these limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465023a1c90479d54baae128a3290d92
https://doi.org/10.1109/embc.2016.7592121
https://doi.org/10.1109/embc.2016.7592121
Publikováno v:
The Journal of Neuroscience. 29:4228-4238
17-beta-Estradiol (E2) is a steroid hormone involved in numerous bodily functions, including several brain functions. In particular, E2 is neuroprotective against excitotoxicity and other forms of brain injuries, a property that requires the extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaca52931bf8265ade9f8feaaa2e0cdf
https://doi.org/10.1523/jneurosci.0550-09.2009
https://doi.org/10.1523/jneurosci.0550-09.2009
Publikováno v:
Frontiers in Computational Neuroscience
Chemical synapses are comprised of a wide collection of intricate signaling pathways involving complex dynamics. These mechanisms are often reduced to simple spikes or exponential representations in order to enable computer simulations at higher spat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078b2d09274b95dab8c7d3379a0b0825
https://doi.org/10.3389/fncom.2015.00112
https://doi.org/10.3389/fncom.2015.00112
Publikováno v:
EMBC
Synaptic transmission is governed by a series of complex and highly nonlinear mechanisms and pathways in which the dynamics have a profound influence on the overall signal sent to the postsynaptic cell. In simulation, these mechanisms are often repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d431d1fec851fa1aba8803e8473bedea
https://doi.org/10.1109/embc.2015.7319095
https://doi.org/10.1109/embc.2015.7319095
Autor:
Serge Bischoff, Jean-Marie C. Bouteiller, Alexander Onopa, Zhuobo Feng, Michel Baudry, Theodore W. Berger, Mike Huang, Endre Somogyi, Eric Y. Hu
Publikováno v:
NER
Computational models are mathematical representations meant to replicate the biological system they represent, as well as provide insights and predict the system's dynamics in response to changing conditions. In a bottom-up modeling approach, a multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f08af7f8a456b5d4ecc75ca9d886f2e
https://doi.org/10.1109/ner.2015.7146619
https://doi.org/10.1109/ner.2015.7146619
Publikováno v:
EMBC
Presynaptic vesicular release of neurotransmitters is a stochastic process involving complex mechanisms triggered by an elevation of calcium concentration. The mechanisms behind neurotransmitters release play a critical role in synaptic function and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4006b994dc03c2bd402dcdca7f15e7
https://pubmed.ncbi.nlm.nih.gov/25570168
https://pubmed.ncbi.nlm.nih.gov/25570168