Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Eric X Chen"'
Autor:
William W. Du, Chi Zhou, Hui Yang, Shuoyang Wen, Yu Chen, Eric X. Chen, Xiuwei H. Yang, Feiya Li, Kevin Y. Du, Hui Yuan, Ting Ye, Javeria Qadir, Burton B. Yang
Publikováno v:
Research, Vol 7 (2024)
Colitis is a chronic bowel disease characterized by damage to the lining of the large intestine, with its precise underlying causes remaining incompletely understood. In this study, we provide evidence that circular RNA circNlgn plays a pivotal role
Externí odkaz:
https://doaj.org/article/0cd0199ab161448a9e670d091141a477
Autor:
Satheesh Krishna, Andrew Sertic, Zhihui (Amy) Liu, Zijin Liu, Gail E. Darling, Jonathon Yeung, Rebecca Wong, Eric X. Chen, Sangeetha Kalimuthu, Michael J. Allen, Chihiro Suzuki, Elan Panov, Lucy X. Ma, Yvonne Bach, Raymond W. Jang, Carol J. Swallow, Savtaj Brar, Elena Elimova, Patrick Veit-Haibach
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
ObjectivesTo identify combined clinical, radiomic, and delta-radiomic features in metastatic gastroesophageal adenocarcinomas (GEAs) that may predict survival outcomes.MethodsA total of 166 patients with metastatic GEAs on palliative chemotherapy wit
Externí odkaz:
https://doaj.org/article/cb4adeee45f74899aa5598ea3cb25dab
Autor:
Mélina Boutin, James T. Topham, Harriet Feilotter, Hagen F. Kennecke, Félix Couture, Mohammed Harb, Peter Kavan, Scott Berry, Howard J. Lim, John R. Goffin, Chaudhary Ahmad, Anthony Lott, Daniel J. Renouf, Derek J. Jonker, Dongsheng Tu, Chris J. O’Callaghan, Eric X. Chen, Jonathan M. Loree
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: The number of somatic mutations detectable in circulating tumor DNA (ctDNA) is highly heterogeneous in metastatic colorectal cancer (mCRC). The optimal number of mutations required to assess disease kinetics is relevant and remains poorly
Externí odkaz:
https://doaj.org/article/e6eff85bf5f845bf871d3d8d86b0404b
Autor:
Eoghan R. Malone, Jeremy Lewin, Xuan Li, Wen‐Jiang Zhang, Susan Lau, Keith Jarvi, Robert J. Hamilton, Aaron R. Hansen, Eric X. Chen, Philippe L. Bedard
Publikováno v:
Cancer Medicine, Vol 11, Iss 3, Pp 728-734 (2022)
Abstract Background Testicular cancer survivors often have impaired gonadal function possibly related to chemotherapy. Platinum is a heavy metal that can be detected at low levels in serum many years after treatment, it is not known whether platinum
Externí odkaz:
https://doaj.org/article/1f3d79b1a97a4f49b6034e4c0a6ef01d
Autor:
Pei Jye Voon, Eric X. Chen, Helen X. Chen, Albert C. Lockhart, Solmaz Sahebjam, Karen Kelly, Ulka N. Vaishampayan, Vivek Subbiah, Albiruni R. Razak, Daniel J. Renouf, Sebastien J. Hotte, Arti Singh, Philippe L. Bedard, Aaron R. Hansen, S. Percy Ivy, Lisa Wang, Lee-Anne Stayner, Lillian L. Siu, Anna Spreafico
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-15 (2022)
Abstract Background Trametinib is an oral MEK 1/2 inhibitor, with a single agent recommended phase 2 dose (RP2D) of 2 mg daily (QD). This study was designed to evaluate RP2D, maximum tolerated dose (MTD), and pharmacokinetic (PK) profile of trametini
Externí odkaz:
https://doaj.org/article/dfe80954e86a42808631f0fc9dd65391
Autor:
Di M. Jiang, Chihiro Suzuki, Osvaldo Espin‐Garcia, Charles H. Lim, Lucy X. Ma, Peiran Sun, Hao‐Wen Sim, Akina Natori, Bryan A. Chan, Stephanie Moignard, Eric X. Chen, Geoffrey Liu, Carol J. Swallow, Gail E. Darling, Rebecca Wong, Raymond W. Jang, Elena Elimova
Publikováno v:
Cancer Medicine, Vol 9, Iss 9, Pp 3023-3032 (2020)
Abstract Background The goal of surveillance testing is to enable curative salvage therapy through early disease detection, however supporting evidence in gastroesophageal adenocarcinoma is limited. We evaluated frequency of successful salvage therap
Externí odkaz:
https://doaj.org/article/c307b0469a764a6eb8cd13f50c8acbc5
Autor:
Ryan Hudnall, Eric X. Chen, Patrick J. Opperman, Sean Kelly, Justin A. Cramer, Daniel L. Surdell
Publikováno v:
Interdisciplinary Neurosurgery, Vol 26, Iss , Pp 101298- (2021)
Purpose: Cerebral cavernous malformations are common central nervous system vascular malformations. They are typically a discrete, well-circumscribed cluster of thin-walled vascular sinusoids with a characteristic “mulberry” or “popcorn” appe
Externí odkaz:
https://doaj.org/article/293c0fe9bc12454481cf53525f60ef41
Autor:
Joseph Longo, Peter J. Mullen, Rosemary Yu, Jenna E. van Leeuwen, Mehdi Masoomian, Dixon T.S. Woon, Yuzhuo Wang, Eric X. Chen, Robert J. Hamilton, Joan M. Sweet, Theodorus H. van der Kwast, Neil E. Fleshner, Linda Z. Penn
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 119-130 (2019)
Objective: The statin family of cholesterol-lowering drugs has been shown to induce tumor-specific apoptosis by inhibiting the rate-limiting enzyme of the mevalonate (MVA) pathway, HMG-CoA reductase (HMGCR). Accumulating evidence suggests that statin
Externí odkaz:
https://doaj.org/article/f03d8eaff63e4e4990bc23cc62eb3734
Autor:
James T. Topham, Chris J. O'Callaghan, Harriet Feilotter, Hagen F. Kennecke, Young S. Lee, Weimin Li, Kimberly C. Banks, Katie Quinn, Daniel J. Renouf, Derek J. Jonker, Dongsheng Tu, Eric X. Chen, Jonathan M. Loree
Publikováno v:
Journal of Clinical Oncology. 41:485-496
PURPOSE Anti–epidermal growth factor receptor (EGFR) antibodies are effective treatments for metastatic colorectal cancer. Improved understanding of acquired resistance mechanisms may facilitate circulating tumor DNA (ctDNA) monitoring, anti-EGFR r
Autor:
Lucy X Ma, Osvaldo Espin-Garcia, Yvonne Bach, Hiroko Aoyama, Michael J Allen, Xin Wang, Gail E Darling, Jonathan Yeung, Carol J Swallow, Savtaj Brar, Patrick Veit-Haibach, Sangeetha Kalimuthu, Rebecca Wong, Eric X Chen, Grainne M O’Kane, Raymond W Jang, Elena Elimova
Publikováno v:
The Oncologist. 28:214-219
4057 Background: While several clinical scoring systems exist to aid prognostication and patient (pt) selection for clinical trials in oncology, none are standardly used. We compared the ability of four prognostic scores to predict overall survival (