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pro vyhledávání: '"Eric Witherspoon"'
Autor:
Eric Witherspoon, Nicholas Zuczek, Gabrielle Williams, Briana Bernstein, Anjik Ghosh, Marko Culjat, Suhasini Kaushal, Patrick A. Forcelli
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionExposure to a range of anti-seizure medications (ASMs) during early brain development adversely impacts neurodevelopmental outcomes in both animal models and in clinical studies. Many ASMs, including phenobarbital, phenytoin, valproate (V
Externí odkaz:
https://doaj.org/article/9959f71ca64c463db4add9fe3d231bb9
Autor:
Irene Sanchez-Brualla, Anjik Ghosh, Viktoriya A. Gibatova, Sean Quinlan, Eric Witherspoon, Stefano Vicini, Patrick A. Forcelli
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionNeonatal hypoxia is a common cause of early-life seizures. Both hypoxia-induced seizures (HS), and the drugs used to treat them (e.g., phenobarbital, PB), have been reported to have long-lasting impacts on brain development. For example,
Externí odkaz:
https://doaj.org/article/d5dd8f24a3a2482bbf43e175406c6a61
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100279- (2020)
Cholinergic neuromodulation plays an important role in numerous cognitive functions including regulating arousal and attention, as well as associative learning and extinction processes. Further, studies demonstrate that cholinergic inputs from the ba
Externí odkaz:
https://doaj.org/article/0d998a9d5dd742eda1603ba717cfcf57
Publikováno v:
Pharmacological Reports. 74:1092-1098
The treatment of epilepsy during early life poses unique challenges-first-line therapies leave many individuals with poorly controlled seizures. In response to the pharmaco-resistance of current first-line anti-seizure drugs (ASDs) during early life,
Publikováno v:
Neurobiology of Stress
Neurobiology of Stress, Vol 13, Iss, Pp 100279-(2020)
Neurobiology of Stress, Vol 13, Iss, Pp 100279-(2020)
Cholinergic neuromodulation plays an important role in numerous cognitive functions including regulating arousal and attention, as well as associative learning and extinction processes. Further, studies demonstrate that cholinergic inputs from the ba