Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Eric W. Stawiski"'
Autor:
Jeffrey D. Wall, J. Fah Sathirapongsasuti, Ravi Gupta, Asif Rasheed, Radha Venkatesan, Saurabh Belsare, Ramesh Menon, Sameer Phalke, Anuradha Mittal, John Fang, Deepak Tanneeru, Manjari Deshmukh, Akshi Bassi, Jacqueline Robinson, Ruchi Chaudhary, Sakthivel Murugan, Zameer ul-Asar, Imran Saleem, Unzila Ishtiaq, Areej Fatima, Saqib Shafi Sheikh, Shahid Hameed, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Anjum Jalal, Shahid Abbas, Philippe Frossard, Christian Fuchsberger, Lukas Forer, Sebastian Schoenherr, Qixin Bei, Tushar Bhangale, Jennifer Tom, Santosh Gopi Krishna Gadde, Priya B V, Naveen Kumar Naik, Minxian Wang, Pui-Yan Kwok, Amit V. Khera, B. R. Lakshmi, Adam S. Butterworth, Rajiv Chowdhury, John Danesh, Emanuele di Angelantonio, Aliya Naheed, Vinay Goyal, Rukmini M. Kandadai, Hrishikesh Kumar, Rupam Borgohain, Adreesh Mukherjee, Pettarusp M. Wadia, Ravi Yadav, Soaham Desai, Niraj Kumar, Atanu Biswas, Pramod Kumar Pal, Uday B. Muthane, Shymal K. Das, Vedam L. Ramprasad, Prashanth L. Kukkle, Somasekar Seshagiri, Sekar Kathiresan, Arkasubhra Ghosh, V. Mohan, Danish Saleheen, Eric W. Stawiski, Andrew S. Peterson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The benefits of large-scale genetic studies for healthcare of the populations studied are well documented, but these genetic studies have traditionally ignored people from some parts of the world, such as South Asia. Here we describe whole g
Externí odkaz:
https://doaj.org/article/c5c553736d824d84a9c6fd8682dcf4dd
Autor:
Kristin M. Zimmerman Savill, Brian B. Lee, Jason Oeh, Jie Lin, Eva Lin, Wei-Jen Chung, Amy Young, Wennie Chen, Monika Miś, Kathryn Mesh, Jeffrey Eastham, Florian Gnad, Zhaoshi Jiang, Eric W. Stawiski, Benjamin Haley, Anneleen Daemen, Xiaojing Wang, Hartmut Koeppen, Zora Modrusan, Scott E. Martin, Deepak Sampath, Kui Lin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
How resistance to different classes of AKT inhibitors can emerge is unclear. Here, the authors show that resistance to allosteric inhibitors is mainly due to mutation of AKT1 while the ATP competitive resistance is driven by activation of PIM kinases
Externí odkaz:
https://doaj.org/article/942eedd4f9f14214ba862fbc21b1991f
Autor:
Kushal Suryamohan, Devan Diwanji, Eric W. Stawiski, Ravi Gupta, Shane Miersch, Jiang Liu, Chao Chen, Ying-Ping Jiang, Frederic A. Fellouse, J. Fah Sathirapongsasuti, Patrick K. Albers, Tanneeru Deepak, Reza Saberianfar, Aakrosh Ratan, Gavin Washburn, Monika Mis, Devi Santhosh, Sneha Somasekar, G. H. Hiranjith, Derek Vargas, Sangeetha Mohan, Sameer Phalke, Boney Kuriakose, Aju Antony, Mart Ustav Jr, Stephan C. Schuster, Sachdev Sidhu, Jagath R. Junutula, Natalia Jura, Somasekar Seshagiri
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Suryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped
Externí odkaz:
https://doaj.org/article/32225ac91a454b1683c6a373e209aa04
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate
Autor:
Akhilesh Pandey, Eric W. Stawiski, Steffen Durinck, Harsha Gowda, Leonard D. Goldstein, Mustafa A. Barbhuiya, Markus S. Schröder, Sreelakshmi K. Sreenivasamurthy, Sun-Whe Kim, Sameer Phalke, Kushal Suryamohan, Kayla Lee, Papia Chakraborty, Vasumathi Kode, Xiaoshan Shi, Aditi Chatterjee, Keshava Datta, Aafaque A. Khan, Tejaswini Subbannayya, Jing Wang, Subhra Chaudhuri, Sanjiv Gupta, Braj Raj Shrivastav, Bijay S. Jaiswal, Satish S. Poojary, Shushruta Bhunia, Patricia Garcia, Carolina Bizama, Lorena Rosa, Wooil Kwon, Hongbeom Kim, Youngmin Han, Thakur Deen Yadav, Vedam L. Ramprasad, Amitabha Chaudhuri, Zora Modrusan, Juan Carlos Roa, Pramod Kumar Tiwari, Jin-Young Jang, Somasekar Seshagiri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Gallbladder cancer incidence shows characteristic geographic patterns. Here the authors perform a genomic analysis of gallbladder cancers in patients from countries with high incidence (South Korea, India and Chile) and identify ELF3 and other signif
Externí odkaz:
https://doaj.org/article/4947118a87984a6abb9c9a6e884df1b9
Autor:
Wenlin Yuan, Leonard D. Goldstein, Steffen Durinck, Ying-Jiun Chen, Thong T. Nguyen, Noelyn M. Kljavin, Ethan S. Sokol, Eric W. Stawiski, Benjamin Haley, James Ziai, Zora Modrusan, Somasekar Seshagiri
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-11 (2019)
Abstract Background PIK3CA mutations are frequent in human breast cancer. Pik3caH1047R mutant expression in mouse mammary gland promotes tumorigenesis. TP53 mutations co-occur with PIK3CA mutations in human breast cancers. We previously generated a c
Externí odkaz:
https://doaj.org/article/bac8665eabf64d8bb2b775dde6b82c72
Autor:
Derek K. Smith, Lance Kates, Steffen Durinck, Nisha Patel, Eric W. Stawiski, Noelyn Kljavin, Oded Foreman, Bence Sipos, Mark J. Solloway, Bernard B. Allan, Andrew S. Peterson
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 5, Pp 100058- (2020)
Summary: The cellular origin of sporadic pancreatic neuroendocrine tumors (PNETs) is obscure. Hormone expression suggests that these tumors arise from glucagon-producing alpha cells or insulin-producing β cells, but instability in hormone expression
Externí odkaz:
https://doaj.org/article/1c910c653f594e98a5df4c10a69d5fe9
Autor:
Viswanathan Mohan, Venkatesan Radha, Thong T. Nguyen, Eric W. Stawiski, Kanika Bajaj Pahuja, Leonard D. Goldstein, Jennifer Tom, Ranjit Mohan Anjana, Monica Kong-Beltran, Tushar Bhangale, Suresh Jahnavi, Radhakrishnan Chandni, Vijay Gayathri, Paul George, Na Zhang, Sakthivel Murugan, Sameer Phalke, Subhra Chaudhuri, Ravi Gupta, Jingli Zhang, Sam Santhosh, Jeremy Stinson, Zora Modrusan, V. L. Ramprasad, Somasekar Seshagiri, Andrew S. Peterson
Publikováno v:
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Maturity-onset diabetes of the young (MODY) is an early-onset, autosomal dominant form of non-insulin dependent diabetes. Genetic diagnosis of MODY can transform patient management. Earlier data on the genetic predisposition to MO
Externí odkaz:
https://doaj.org/article/d6c8437dec844385a226c2db1c84a725
Autor:
Somasekar Seshagiri, Zora Modrusan, Scott E. Martin, John Moffat, Eva Lin, Weiru Wang, Jianping Yin, Eric W. Stawiski, Steffen Durinck, Bijay S. Jaiswal
Supplementary Table S1: X-ray crystallography data processing and structure refinement statistics Supplementary Table S2: BRAF and RAS mutational status of cell lines used in the study Supplementary Table: S3: Cellular IC50 (nM) of parental and ERKi-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a818d88cbb2792b0dc8376b635414b
https://doi.org/10.1158/1078-0432.22475625
https://doi.org/10.1158/1078-0432.22475625
Autor:
Somasekar Seshagiri, Zora Modrusan, Scott E. Martin, John Moffat, Eva Lin, Weiru Wang, Jianping Yin, Eric W. Stawiski, Steffen Durinck, Bijay S. Jaiswal
Purpose: MAPK pathway inhibitors targeting BRAF and MEK have shown clinical efficacy in patients with RAF- and/or RAS-mutated tumors. However, acquired resistance to these agents has been an impediment to improved long-term survival in the clinic. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e9fdf05a747ff859670a43c8cc3d77
https://doi.org/10.1158/1078-0432.c.6529128
https://doi.org/10.1158/1078-0432.c.6529128
Autor:
Somasekar Seshagiri, Zora Modrusan, Scott E. Martin, John Moffat, Eva Lin, Weiru Wang, Jianping Yin, Eric W. Stawiski, Steffen Durinck, Bijay S. Jaiswal
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395ca6436d6c1d18c409c6cbe9805ecd
https://doi.org/10.1158/1078-0432.22475637.v1
https://doi.org/10.1158/1078-0432.22475637.v1