Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Eric W. Schmidt"'
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110834- (2024)
Summary: The varied pigments found in animals play both ecological and physiological roles. Virtually all echinoderms contain putative pigment biosynthetic enzymes, the polyketide synthases (PKSs). Among these, crinoids have complex pigments found bo
Externí odkaz:
https://doaj.org/article/db910d340f3046fba0eee822f02f98e2
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Animals synthesize simple lipids using a distinct fatty acid synthase (FAS) related to the type I polyketide synthase (PKS) enzymes that produce complex specialized metabolites. The evolutionary origin of the animal FAS and its relationship
Externí odkaz:
https://doaj.org/article/a1c8dbea0fb34a798fadcda3fcf72d7a
Autor:
Albebson L. Lim, Bailey W. Miller, Zhenjian Lin, Mark A. Fisher, Louis R. Barrows, Margo G. Haygood, Eric W. Schmidt
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Turnercyclamycin A and B lipopeptides exhibit Gram-negative bacteria-specific toxicity. This includes CDC urgent threat organisms such as multidrug-resistant Acinetobacter baumannii. Like the last-line agent colistin, turnercyclamycins inter
Externí odkaz:
https://doaj.org/article/54c4046ef672420ebbd5753d2a69f3bd
Autor:
Lili Sun, Jie Zhang, Changshan Niu, Cassandra E. Deering-Rice, Ronald W. Hughen, John G. Lamb, Katherine Rose, Kevin M. Chase, Marysol Almestica-Roberts, Markel Walter, Eric W. Schmidt, Alan R. Light, Baldomero M. Olivera, Christopher A. Reilly
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 68-81 (2023)
Pain is often debilitating, and current treatments are neither universally efficacious nor without risks. Transient receptor potential (TRP) ion channels offer alternative targets for pain relief, but little is known about the regulation or identitie
Externí odkaz:
https://doaj.org/article/6bb12ec7d65448d6a83796dbcdf8242d
Autor:
Eric W. Schmidt, Zhenjian Lin
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Chemists have studied marine animals for the better part of a century because they contain a diverse array of bioactive compounds. Tens of thousands of compounds have been reported, many with elaborate structural motifs and biological mechan
Externí odkaz:
https://doaj.org/article/10fb51b0ec0f40ecb74e07aef9f5b58b
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Complex polyketides are usually produced by microbes, whereas the origin of polyketides found in animals remained unknown. This study shows that sacoglossan animals, such as sea slugs, employ fatty acid synthase-like proteins to produce microbe-like
Externí odkaz:
https://doaj.org/article/e4be631f0db64b18a746004d3fa1c1f3
Autor:
Zhenjian Lin, Joshua P. Torres, Maren Watkins, Noemi Paguigan, Changshan Niu, Julita S. Imperial, Jortan Tun, Helena Safavi-Hemami, Rocio K. Finol-Urdaneta, Jorge L. B. Neves, Samuel Espino, Manju Karthikeyan, Baldomero M. Olivera, Eric W. Schmidt
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Venomous molluscs (Superfamily Conoidea) comprise a substantial fraction of tropical marine biodiversity (>15,000 species). Prior characterization of cone snail venoms established that bioactive venom components used to capture prey, defend against p
Externí odkaz:
https://doaj.org/article/d53cb04f1077429cb543b44418d5afd0
Autor:
Marvin A. Altamia, Zhenjian Lin, Amaro E. Trindade-Silva, Iris Diana Uy, J. Reuben Shipway, Diego Veras Wilke, Gisela P. Concepcion, Daniel L. Distel, Eric W. Schmidt, Margo G. Haygood
Publikováno v:
mSystems, Vol 6, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/2ab46a0eab394c52afeedf41beea9df8
Autor:
Marvin A. Altamia, Zhenjian Lin, Amaro E. Trindade-Silva, Iris Diana Uy, J. Reuben Shipway, Diego Veras Wilke, Gisela P. Concepcion, Daniel L. Distel, Eric W. Schmidt, Margo G. Haygood
Publikováno v:
mSystems, Vol 5, Iss 3 (2020)
ABSTRACT Shipworms play critical roles in recycling wood in the sea. Symbiotic bacteria supply enzymes that the organisms need for nutrition and wood degradation. Some of these bacteria have been grown in pure culture and have the capacity to make ma
Externí odkaz:
https://doaj.org/article/6d47976743a642bb8dd56d024294a1b8
Autor:
Roberta M O'Connor, Felix J Nepveux V, Jaypee Abenoja, Gregory Bowden, Patricia Reis, Josiah Beaushaw, Rachel M Bone Relat, Iwona Driskell, Fernanda Gimenez, Michael W Riggs, Deborah A Schaefer, Eric W Schmidt, Zhenjian Lin, Daniel L Distel, Jon Clardy, Timothy R Ramadhar, David R Allred, Heather M Fritz, Pradipsinh Rathod, Laura Chery, John White
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008600 (2020)
Apicomplexan parasites cause severe disease in both humans and their domesticated animals. Since these parasites readily develop drug resistance, development of new, effective drugs to treat infection caused by these parasites is an ongoing challenge
Externí odkaz:
https://doaj.org/article/f409fe1b5c164785aed21bd8fb436bc8