Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Eric W Brunskill"'
Autor:
Francis M Kobia, Kristina Preusse, Quanhui Dai, Nicholas Weaver, Matthew R Hass, Praneet Chaturvedi, Sarah J Stein, Warren S Pear, Zhenyu Yuan, Rhett A Kovall, Yi Kuang, Natanel Eafergen, David Sprinzak, Brian Gebelein, Eric W Brunskill, Raphael Kopan
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000850 (2020)
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for
Externí odkaz:
https://doaj.org/article/56bb8176d92c404f8da9d4b31d6102f3
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0216261 (2019)
Focal segmental glomerulosclerosis is a major cause of end stage renal disease. Many patients prove unresponsive to available therapies. An improved understanding of the molecular basis of the disease process could provide insights leading to novel t
Externí odkaz:
https://doaj.org/article/0bb07f4453cd45abae649a4b5ca7a050
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24640 (2011)
The podocyte is a remarkable cell type, which encases the capillaries of the kidney glomerulus. Although mesodermal in origin it sends out axonal like projections that wrap around the capillaries. These extend yet finer projections, the foot processe
Externí odkaz:
https://doaj.org/article/89c8ed94655748249e833694ff4bb79b
Autor:
Eric W Brunskill, S Steven Potter
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12034 (2010)
Endothelial cells are remarkably heterogeneous in both morphology and function, and they play critical roles in the formation of multiple organ systems. In addition endothelial cell dysfunction can contribute to disease processes, including diabetic
Externí odkaz:
https://doaj.org/article/7a08fdca138a407f8065f512143c961f
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mammalian nephron endowment is determined by the coordinated cessation of nephrogenesis in independent niches. Here we report that translatome analysis in Tsc1+/− nephron progenitor cells from mice with elevated nephron numbers reveals how differen
Mammalian nephron endowment is determined by the coordinated cessation of nephrogenesis in independent niches. Here we report that in young niches, cellular Wnt agonists are poorly translated, Fgf20 levels are high and R-spondin levels are low, resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc21d214c89ac26d37ccdd555583e60f
https://doi.org/10.1101/2020.03.12.989343
https://doi.org/10.1101/2020.03.12.989343
Autor:
Raphael Kopan, Brian Gebelein, Francis M. Kobia, Sarah J. Stein, Rhett A. Kovall, Warren S. Pear, Kristina Preusse, Quanhui Dai, Yi Kuang, David Sprinzak, Natanel Eafergen, Eric W. Brunskill, Praneet Chaturvedi, Nicholas Weaver, Matthew R. Hass, Zhenyu Yuan
Publikováno v:
PLoS Biology
PLoS Biology, Vol 18, Iss 10, p e3000850 (2020)
PLoS Biology, Vol 18, Iss 10, p e3000850 (2020)
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for
Autor:
Nathan Salomonis, Christian I. Hong, Raphael Kopan, Eric W. Brunskill, Phillip J. Dexheimer, Tongli Zhang, S. Steven Potter, Bruce J. Aronow, Shuang Chen
Publikováno v:
Developmental Cell. 35(1):49-62
SummaryDuring fetal development, nephrons of the metanephric kidney form from a mesenchymal progenitor population that differentiates en masse before or shortly after birth. We explored intrinsic and extrinsic mechanisms controlling progenitor lifesp
Autor:
Bruce J. Aronow, Andrew J. Plassard, Andrew S. Potter, Andrew DiStasio, Phillip J. Dexheimer, S. Steven Potter, Eric W. Brunskill
Publikováno v:
Developmental Biology. 391:133-146
We present a gene expression atlas of early mouse craniofacial development. Laser capture microdissection (LCM) was used to isolate cells from the principal critical microregions, whose development, differentiation and signaling interactions are resp
Publikováno v:
Developmental Biology. 381:312-323
Much of the bone, cartilage and smooth muscle of the vertebrate face is derived from neural crest (NC) cells. During craniofacial development, the anterior neural ridge (ANR) and olfactory pit (OP) signaling centers are responsible for driving the ou