STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL2 and BCLXL following glucocorticoid treatment

Autor: Jordy C.G. van der Zwet, Valentina Cordo’, Jessica G.C.A.M. Buijs-Gladdines, Rico Hagelaar, Willem K. Smits, Eric Vroegindeweij, Laura T.M. Graus, Vera Poort, Marloes Nulle, Rob Pieters, Jules P.P. Meijerink

Publikováno v: Haematologica, Vol 108, Iss 3 (2022)

Physiological and pathogenic interleukin-7-receptor (IL7R)-induced signaling provokes glucocorticoid resistance in a subset of patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL). Activation of downstream STAT5 has been suggested to c

Externí odkaz: https://doaj.org/article/67b16264c0434bffacc7a8302e7a785b

STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of

Autor: Jordy C G, Van der Zwet, Valentina, Cordo', Jessica G C A M, Buijs-Gladdines, Rico, Hagelaar, Willem K, Smits, Eric, Vroegindeweij, Laura T M, Graus, Vera, Poort, Marloes, Nulle, Rob, Pieters, Jules P P, Meijerink

Publikováno v: Haematologica.

Physiologic and pathogenic IL7-receptor (IL7R) induced signaling provokes glucocorticoid resistance in a subset of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients. Activation of downstream STAT5 has been suggested to cause steroid resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8fe7a19033376fd45a0c0b1f0160842
https://pubmed.ncbi.nlm.nih.gov/35734930

IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study

Autor: Ronald van Marion, Andrew P. Stubbs, R.C. Buijsman, Rob Pieters, Eric Vroegindeweij, Guido J.R. Zaman, Willem K. Smits, Kirsten Canté-Barrett, Peter J. van der Spek, Jessica G.C.A.M. Buijs-Gladdines, Roland P. Kuiper, Yunlei Li, Winand N.M. Dinjens, Martin A. Horstmann, Jules P.P. Meijerink

Publikováno v: PLoS Medicine, Vol 13, Iss 12, p e1002200 (2016)
PLoS Medicine
PLoS Medicine (online), 13(12):e1002200. Public Library of Science

Background Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the leading cause of cancer-related mortality in children. T cell ALL (T-ALL) represents about 15% of pediatric ALL cases and is considered a high-risk di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f3ec8a6a2019ee615d0d66a655501a
http://europepmc.org/articles/PMC5172551?pdf=render

Characterization of Lgr5-positive epithelial cells in the murine thymus

Autor: Irene van Mourik, Tom Cupedo, Eric Vroegindeweij, Jan J. Cornelissen

Publikováno v: European Journal of Immunology. 43:1243-1251

Leucine-rich repeat-containing G protein-coupled receptor (Lgr)5 is a marker for epithelial stem cells in the adult intestine of mice. Lgr5 transcripts have also been detected in the developing murine thymus, leading to speculation that Lgr5 is a mar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea91cd5f424535ebaa1e19cbed5cb3a1
https://doi.org/10.1002/eji.201242947

Dynamics of thymus organogenesis and colonization in early human development

Autor: Eric Vroegindeweij, C. Clare Blackburn, Frances H. Stenhouse, Lucy Morris, Harsh J. Vaidya, Marianne L G Depreter, Alison Farley, Richard A. Anderson, Jan J. Cornelissen, Simon R. Tomlinson, Tom Cupedo

Publikováno v: Farley, A M, Morris, L X, Vroegindeweij, E, Depreter, M L G, Vaidya, H, Stenhouse, F H, Tomlinson, S R, Anderson, R A, Cupedo, T, Cornelissen, J J & Blackburn, C C 2013, ' Dynamics of thymus organogenesis and colonization in early human development ', Development, vol. 140, no. 9, pp. 2015-2026 . https://doi.org/10.1242/dev.087320
Development (Cambridge, England)
Development, 140(9), 2015-2026. Company of Biologists Ltd

The thymus is the central site of T-cell development and thus is of fundamental importance to the immune system, but little information exists regarding molecular regulation of thymus development in humans. Here we demonstrate, via spatial and tempor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51113712341326b9a95ce66f16a0751
https://hdl.handle.net/20.500.11820/a6266cd9-f720-4a88-80be-b328d88a8316