Zobrazeno 1 - 10
of 461
pro vyhledávání: '"Eric Verdin"'
Autor:
Marius Walter, Anoria K. Haick, Rebeccah Riley, Paola A. Massa, Daniel E. Strongin, Lindsay M. Klouser, Michelle A. Loprieno, Laurence Stensland, Tracy K. Santo, Pavitra Roychoudhury, Martine Aubert, Matthew P. Taylor, Keith R. Jerome, Eric Verdin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Gene drives are genetic modifications designed to propagate efficiently through a population. Most applications rely on homologous recombination during sexual reproduction in diploid organisms such as insects, but we recently developed a gen
Externí odkaz:
https://doaj.org/article/acd1c8473e194f38b1e8720b1d136bac
Autor:
Alan Tomusiak, Ariel Floro, Ritesh Tiwari, Rebeccah Riley, Hiroyuki Matsui, Nicolas Andrews, Herbert G. Kasler, Eric Verdin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic age relative to chronological age (epigenetic age accel
Externí odkaz:
https://doaj.org/article/bc8d0826fa71413d9bde7369cffd7143
Autor:
Dean Ornish, Catherine Madison, Miia Kivipelto, Colleen Kemp, Charles E. McCulloch, Douglas Galasko, Jon Artz, Dorene Rentz, Jue Lin, Kim Norman, Anne Ornish, Sarah Tranter, Nancy DeLamarter, Noel Wingers, Carra Richling, Rima Kaddurah-Daouk, Rob Knight, Daniel McDonald, Lucas Patel, Eric Verdin, Rudolph E. Tanzi, Steven E. Arnold
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Evidence links lifestyle factors with Alzheimer’s disease (AD). We report the first randomized, controlled clinical trial to determine if intensive lifestyle changes may beneficially affect the progression of mild cognitive impa
Externí odkaz:
https://doaj.org/article/88f3200bfb0542db8b347084c5b976dd
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103074- (2024)
Summary: Lysine malonylation is a protein posttranslational modification. We present a protocol to generate stable gene-knockdown K562 cell lines through lentiviral infection of a CRISPR interference (CRISPRi) system followed by lysine malonylation m
Externí odkaz:
https://doaj.org/article/5ff7c7179f8a4985bab2dca07820f187
Autor:
Delphine Massé, Thierry Candresse, Denis Filloux, Sébastien Massart, Nathalie Cassam, Bruno Hostachy, Armelle Marais, Emmanuel Fernandez, Philippe Roumagnac, Eric Verdin, Pierre-Yves Teycheney, Jean-Michel Lett, Pierre Lefeuvre
Publikováno v:
Viruses, Vol 16, Iss 7, p 1146 (2024)
The cultivation of pineapple (Ananas comosus) is threatened worldwide by mealybug wilt disease of pineapple (MWP), whose etiology is not yet fully elucidated. In this study, we characterized pineapple mealybug wilt-associated ampeloviruses (PMWaVs, f
Externí odkaz:
https://doaj.org/article/fe4e11103fd7456388bfe9f8d173957b
Autor:
Chris Carrico, Andrew Cruz, Marius Walter, Jesse Meyer, Cameron Wehrfritz, Samah Shah, Lei Wei, Birgit Schilling, Eric Verdin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications that regulate protein function. In mitochondria, lysine acylation is predominantly non-enzymatic, and only a specific subset of the proteome is
Externí odkaz:
https://doaj.org/article/b718fbde6dbd4edebb61ac04bfebc4d0
Autor:
Rosalba Perrone, Prasanna Vadhana Ashok Kumaar, Lauren Haky, Cosmo Hahn, Rebeccah Riley, Julia Balough, Giuliana Zaza, Bikem Soygur, Kaitlyn Hung, Leandro Prado, Herbert G. Kasler, Ritesh Tiwari, Hiroyuki Matsui, Genesis Vega Hormazabal, Indra Heckenbach, Morten Scheibye-Knudsen, Francesca E. Duncan, Eric Verdin
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107949- (2023)
Summary: Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show
Externí odkaz:
https://doaj.org/article/b684e354f37142c3801059b7ca25046d
Autor:
Rachid Boutoual, Hyunsun Jo, Indra Heckenbach, Ritesh Tiwari, Herbert Kasler, Chad A. Lerner, Samah Shah, Birgit Schilling, Vincenzo Calvanese, Matthew J. Rardin, Morten Scheibye-Knudsen, Eric Verdin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Post-translational modifications, such as lysine acetylation, regulate the activity of diverse proteins across many cellular compartments. Protein deacetylation in mitochondria is catalyzed by the enzymatic activity of the NAD+-dependent dea
Externí odkaz:
https://doaj.org/article/b028fc2b6f7e4beeb56bfa8dbba5cc9e
Autor:
Ran Zhang, Joanna Bons, Grace Scheidemantle, Xiaojing Liu, Olga Bielska, Chris Carrico, Jacob Rose, Indra Heckenbach, Morten Scheibye-Knudsen, Birgit Schilling, Eric Verdin
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106193- (2023)
Summary: The posttranslational modification lysine malonylation is found in many proteins, including histones. However, it remains unclear whether histone malonylation is regulated or functionally relevant. Here, we report that availability of malony
Externí odkaz:
https://doaj.org/article/163eef16f75240ae901b4483744024e4
Autor:
Judith Hirsch, Marion Szadkowski, Catherine Wipf-Scheibel, Elise Lepage, Paul Dumeaux, Elodie Nguyen, Eric Verdin, Benoît Moury, Loup Rimbaud
Publikováno v:
Viruses, Vol 15, Iss 11, p 2159 (2023)
In the past decade, severe epidemics of cucumber mosaic virus (CMV) have caused significant damage to Espelette pepper crops. This virus threatens the production of Espelette pepper, which plays a significant role in the local economy and touristic a
Externí odkaz:
https://doaj.org/article/eadf814242a84ca1bed41e53acde442f