Výsledky vyhledávání - "Eric VanCutsem"

Impact of RAS mutations on immunologic characteristics of the tumor microenvironment (TME) in patients with microsatellite instability-high (MSI-H) or mismatch-repair–deficient (dMMR) colorectal cancer (CRC)

Autor: Mohamed E. Salem, Thierry Andre, Sherif Mohamed El-Refai, Scott Kopetz, Josep Tabernero, Frank A. Sinicrope, Jeanne Tie, Thomas J. George, Eric VanCutsem, Elizabeth Mauer, Sara Lonardi, Michael J. Overman, David Foureau

Publikováno v: Journal of Clinical Oncology. 40:3067-3067

3067 Background: The KEYNOTE-177 trial demonstrated pembrolizumab’s superiority over first-line chemotherapy in patients with MSI-H/dMMR mCRC. However, in a subgroup analysis, patients with KRAS or NRAS mutations did not show the same favorable PFS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d99e9e1e992f347c6bd52aa086d78f38
https://doi.org/10.1200/jco.2022.40.16_suppl.3067

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Comparative analysis of microsatellite instability-high (MSI-H) BRAF V600E-mutated versus MSI-H BRAFwild type colorectal cancers (CRC), including tumor microenvironment (TME), associated genomic alterations, and immunometabolomic biomarkers

Autor: Mohamed E. Salem, Scott Kopetz, Sherif Mohamed El-Refai, Josep Tabernero, Frank A. Sinicrope, Jeanne Tie, Thomas J. George, Eric VanCutsem, Elizabeth Mauer, Sara Lonardi, Thierry Andre, Michael J. Overman, David Foureau

Publikováno v: Journal of Clinical Oncology. 40:3066-3066

3066 Background: The BRAFV600E mutation is associated with the hypermethylator phenotype CIMP, which can also lead to the MSI-H phenotype. BRAFV600E mutation and MSI-H/dMMR status seem to be biologically intertwined; however, the impact of coexisting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5934872dcb702bcedf7eace0f7813893
https://doi.org/10.1200/jco.2022.40.16_suppl.3066

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Sex and Adverse Events of Adjuvant Chemotherapy in Colon Cancer: An Analysis of 34 640 Patients in the ACCENT Database

Publikováno v: J Natl Cancer Inst

Background Adjuvant chemotherapy is a standard treatment option for patients with stage III and high-risk stage II colon cancer. Sex is one of several factors responsible for the wide inter-patient variability in drug responses. Amalgamated data on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309b2f83e2def9ed8b5c94b96c037167
https://pubmed.ncbi.nlm.nih.gov/32835362

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Survival outcomes among older adults (OA) receiving second-line therapy for metastatic CRC (mCRC): 5,289 patients (pts) from the ARCAD Clinical Trials Program

Autor: Arnold Dirk, Mace L. Rothenberg, Qian Shi, Paulo M. Hoff, William S. Harmsen, Josep Tabernero, Eric VanCutsem, Leonard B. Saltz, Alfredo Falcone, Matthew T. Seymour, Richard M. Goldberg, Hans-Joachim Schmoll, Alberto Sobrero, Henry C. Pitot, Aimery de Gramont, Bruce J. Giantonio, Nadine Jackson McCleary, Miriam Koopman

Publikováno v: Web of Science

7009 Background: Survival outcomes of 2nd line mCRC therapy for OA are poorly understood. We evaluated the rates and survival outcomes of 2nd line therapy among OA age 70+ compared to younger adults (YA) age < 70 following progression on 1st line cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15625054be026e224db1a0963a23a299
https://doi.org/10.1200/jco.2020.38.15_suppl.7009

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Association of sex and adverse events (AEs) of adjuvant chemotherapy (ACT) in early stage colon cancer (CC): A pooled analysis of 28,636 patients (pts) in the ACCENT database

Publikováno v: Journal of Clinical Oncology. 36:3603-3603

3603Background: Sex is one of several factors known to affect drug efficacy and toxicity. Preliminary data in different types of cancers suggest a higher toxicity of chemotherapy in women. Aim of t...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdca71da977db83a9d0f5cadbbd14026
https://doi.org/10.1200/jco.2018.36.15_suppl.3603

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A Dynamic Model of Hand-and-Foot Syndrome in Patients Receiving Capecitabine

Autor: Pascal Girard, Emilie Henin, Paulo M. Hoff, Gilles Freyer, Céline Dartois, Eric VanCutsem, Florin Sirzen, Klaas P. Zuideveld, Michel Tod, Jim Cassidy, Benoit You, Chris Twelves

Publikováno v: Clinical Pharmacology & Therapeutics. 85:418-425

For the purpose of developing a longitudinal model to predict hand-and-foot syndrome (HFS) dynamics in patients receiving capecitabine, data from two large phase III studies were used. Of 595 patients in the capecitabine arms, 400 patients were rando

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fdbd5b00a8d67463600e148baabe0a
https://doi.org/10.1038/clpt.2008.220

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