Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Eric Valeur"'
Autor:
Hélène Adihou, Ranganath Gopalakrishnan, Tim Förster, Stéphanie M. Guéret, Raphael Gasper, Stefan Geschwindner, Carmen Carrillo García, Hacer Karatas, Ajaybabu V. Pobbati, Mercedes Vazquez‐Chantada, Paul Davey, Carola M. Wassvik, Jeremy Kah Sheng Pang, Boon Seng Soh, Wanjin Hong, Elisabetta Chiarparin, Dennis Schade, Alleyn T. Plowright, Eric Valeur, Malin Lemurell, Tom N. Grossmann, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEA
Externí odkaz:
https://doaj.org/article/34105208594045348e3822ea97b488f7
Autor:
Eric Valeur
Publikováno v:
The Handbook of Medicinal Chemistry ISBN: 9781788018982
Over the last decade, the landscape of therapeutic modalities has been deeply transformed by the development of novel chemical classes challenging the supremacy of small molecules and antibodies/biologics. Many of these New Modalities have now reache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d4b1a7a8cacb4c1656f0f1604217f6c
https://doi.org/10.1039/9781788018982-00911
https://doi.org/10.1039/9781788018982-00911
Autor:
Punit P. Seth, Johan Broddefalk, Patrik U. Andersson, Johan Meuller, Michael E. Østergaard, Thazha P. Prakash, Linda Sundström, Leonardo De Maria, Wuxia Fu, Ahlke Hayen, David Janzén, Carina Ämmälä, Eric Valeur, Laurent Knerr, Maria Ölwegård-Halvarsson, Richard G. Lee, Shalini Andersson, William J. Drury, Elaine Pirie, Mehran Nikan, Rasmus Jansson-Löfmark
Publikováno v:
Journal of the American Chemical Society. 143:3416-3429
The extra hepatic delivery of antisense oligonucleotides (ASOs) remains a challenge and hampers the widespread application of this powerful class of therapeutic agents. In that regard, pancreatic beta cells are a particularly attractive but challengi
Autor:
Stefan Geschwindner, Mercedes Vazquez-Chantada, Hacer Karatas, Carmen Carrillo García, Elisabetta Chiarparin, Dennis Schade, Malin Lemurell, Tom N. Grossmann, Paul R. J. Davey, Alleyn T. Plowright, Jeremy Kah Sheng Pang, Hélène Adihou, Boon Seng Soh, Stéphanie M. Guéret, Wanjin Hong, Carola M. Wassvik, Ranganath Gopalakrishnan, Eric Valeur, Tim Förster, Herbert Waldmann, Raphael Gasper, Ajaybabu V. Pobbati
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Adihou, H, Gopalakrishnan, R, Förster, T, Guéret, S M, Gasper, R, Geschwindner, S, Carrillo García, C, Karatas, H, Pobbati, A V, Vazquez-Chantada, M, Davey, P, Wassvik, C M, Pang, J K S, Soh, B S, Hong, W, Chiarparin, E, Schade, D, Plowright, A T, Valeur, E, Lemurell, M, Grossmann, T N & Waldmann, H 2020, ' A protein tertiary structure mimetic modulator of the Hippo signalling pathway ', Nature Communications, vol. 11, no. 1, 5425 . https://doi.org/10.1038/s41467-020-19224-8
Nature Communications, 11(1):5425. Nature Publishing Group
Nature Communications
Adihou, H, Gopalakrishnan, R, Förster, T, Guéret, S M, Gasper, R, Geschwindner, S, Carrillo García, C, Karatas, H, Pobbati, A V, Vazquez-Chantada, M, Davey, P, Wassvik, C M, Pang, J K S, Soh, B S, Hong, W, Chiarparin, E, Schade, D, Plowright, A T, Valeur, E, Lemurell, M, Grossmann, T N & Waldmann, H 2020, ' A protein tertiary structure mimetic modulator of the Hippo signalling pathway ', Nature Communications, vol. 11, no. 1, 5425 . https://doi.org/10.1038/s41467-020-19224-8
Nature Communications, 11(1):5425. Nature Publishing Group
Nature Communications
Transcription factors are key protein effectors in the regulation of gene transcription, and in many cases their activity is regulated via a complex network of protein–protein interactions (PPI). The chemical modulation of transcription factor acti
Autor:
Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams
Publikováno v:
Journal of Medicinal Chemistry. 63:5697-5722
Autor:
Niklas Larsson, Eric Valeur, Marco Potowski, Herbert Waldmann, Sasikala Thavam, Tom N. Grossmann, Anita Dellsén, Alleyn T. Plowright, Rodrigo J. Carbajo, Stéphanie M. Guéret, Malin Lemurell, Göran Dahl
Publikováno v:
Journal of the American Chemical Society, 142(10), 4904-4915. American Chemical Society
Journal of the American Chemical Society
Guéret, S M, Thavam, S, Carbajo, R J, Potowski, M, Larsson, N, Dahl, G, Dellsén, A, Grossmann, T N, Plowright, A T, Valeur, E, Lemurell, M & Waldmann, H 2020, ' Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments ', Journal of the American Chemical Society, vol. 142, no. 10, pp. 4904-4915 . https://doi.org/10.1021/jacs.0c00269
Journal of the American Chemical Society
Guéret, S M, Thavam, S, Carbajo, R J, Potowski, M, Larsson, N, Dahl, G, Dellsén, A, Grossmann, T N, Plowright, A T, Valeur, E, Lemurell, M & Waldmann, H 2020, ' Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments ', Journal of the American Chemical Society, vol. 142, no. 10, pp. 4904-4915 . https://doi.org/10.1021/jacs.0c00269
"Hot loop" protein segments have variable structure and conformation and contribute crucially to protein-protein interactions. We describe a new hot loop mimicking modality, termed PepNats, in which natural product (NP)-inspired structures are incorp
Autor:
Ranganath Gopalakrishnan, Anaïs F. M. Noisier, Martin A. Hayes, Lara R. Malins, Magnus Johansson, William J. Drury, Eric Valeur, Laurent Knerr
Publikováno v:
Angewandte Chemie. 131:19272-19278
The late-stage functionalization (LSF) of peptides represents a valuable strategy for the design of potent peptide pharmaceuticals by enabling rapid exploration of chemical diversity and offering novel opportunities for peptide conjugation. While the
Publikováno v:
Medchemcomm
An increasing focus on complex biology to cure diseases rather than merely treat symptoms has transformed how drug discovery can be approached. Instead of activating or blocking protein function, a growing repertoire of drug modalities can be leverag
Autor:
Eric Valeur
Publikováno v:
Protein Degradation with New Chemical Modalities ISBN: 9781788016865
Drug discovery has experienced repeated waves of innovation during the last three decades. Over time, small molecules were complemented with biologics to expand the range of therapeutic opportunities. With many successful treatments reaching the mark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b32ee557c172b5baf4784b5cd492eb4c
https://doi.org/10.1039/9781839160691-00277
https://doi.org/10.1039/9781839160691-00277
Publikováno v:
Nature Reviews Drug Discovery. 16:681-698
The strong biological rationale to pursue challenging drug targets such as protein-protein interactions has stimulated the development of novel screening strategies, such as DNA-encoded libraries, to allow broader areas of chemical space to be search