Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Eric Tycksen"'
Autor:
Stuart B. Fass, Bernard Mulvey, Rebecca Chase, Wei Yang, Din Selmanovic, Sneha M. Chaturvedi, Eric Tycksen, Lauren A. Weiss, Joseph D. Dougherty
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Background Sex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions. Methods In order to understand the transcriptional basis of sex differences, we analyzed multiple, large-scale,
Externí odkaz:
https://doaj.org/article/659267bf36424f10b6dc38a41aa18e59
Autor:
Tusar Giri, Susan E. Maloney, Saswat Giri, Young Ah Goo, Jong Hee Song, Minsoo Son, Eric Tycksen, Sara B. Conyers, Annie Bice, Xia Ge, Joel R. Garbow, James D. Quirk, Adam Q. Bauer, Arvind Palanisamy
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108960- (2024)
Summary: Despite six decades of the use of exogenous oxytocin for management of labor, little is known about its effects on the developing brain. Motivated by controversial reports suggesting a link between oxytocin use during labor and autism spectr
Externí odkaz:
https://doaj.org/article/e9e5b58417e84477920ca10e804cdb9a
Autor:
Yeawon Kim, Chuang Li, Chenjian Gu, Yili Fang, Eric Tycksen, Anuradhika Puri, Terri A. Pietka, Jothilingam Sivapackiam, Kendrah Kidd, Sun-Ji Park, Bryce G. Johnson, Stanislav Kmoch, Jeremy S. Duffield, Anthony J. Bleyer, Meredith E. Jackrel, Fumihiko Urano, Vijay Sharma, Maria Lindahl, Ying Maggie Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD), a leading hereditary kidney disease. There are no targeted therapies. In our
Externí odkaz:
https://doaj.org/article/72c2d4d2fcd54509bc61bc5046fee857
Autor:
Nidhi Rohatgi, Wei Zou, Yongjia Li, Kevin Cho, Patrick L. Collins, Eric Tycksen, Gaurav Pandey, Carl J. DeSelm, Gary J. Patti, Anwesha Dey, Steven L. Teitelbaum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Treatment of osteoporosis commonly diminishes osteoclast number which suppresses bone formation thus compromising fracture prevention. Bone formation is not suppressed, however, when bone degradation is reduced by retarding osteoclast functi
Externí odkaz:
https://doaj.org/article/cccf1d8177fb4ec0a2c526ee79cec6f1
Autor:
Tusar Giri, Jia Jiang, Zhiqiang Xu, Ronald McCarthy, Carmen M. Halabi, Eric Tycksen, Alison G. Cahill, Sarah K. England, Arvind Palanisamy
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Despite the widespread use of oxytocin for induction of labor, mechanistic insights into fetal/neonatal wellbeing are lacking because of the absence of an animal model that recapitulates modern obstetric practice. Here, we create and validat
Externí odkaz:
https://doaj.org/article/4d38c134bb1f485a9120cb40bbe9b4c8
Autor:
Mary Elizabeth Mathyer, Erin A. Brettmann, Alina D. Schmidt, Zane A. Goodwin, Inez Y. Oh, Ashley M. Quiggle, Eric Tycksen, Natasha Ramakrishnan, Scot J. Matkovich, Emma Guttman-Yassky, John R. Edwards, Cristina de Guzman Strong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Selection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and
Externí odkaz:
https://doaj.org/article/562d1faba6444cc8a292faa17015f06a
Autor:
Kristina Sakers, Yating Liu, Lorida Llaci, Scott M. Lee, Michael J. Vasek, Michael A. Rieger, Sean Brophy, Eric Tycksen, Renate Lewis, Susan E. Maloney, Joseph D. Dougherty
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Quaking RNA binding protein (QKI) is known for its role in oligodendrocyte maturation. Here, the authors define the QKI targets in the mouse brain and show that loss of QKI disrupts the expression of cell maturation-associated genes in astrocytes in
Externí odkaz:
https://doaj.org/article/4e48d16143194a59a45f452f5de15b87
Autor:
Francesca Fontana, Jingyu Xiang, Xinming Su, Eric Tycksen, Rachel Nassau, Gregory Fox, Giulia Leanza, Katherine Weilbaecher, Roberto Civitelli
Publikováno v:
Journal of Bone Oncology, Vol 28, Iss , Pp 100356- (2021)
Tumor growth and metastases are dependent on interactions between cancer cells and the local environment. Expression of the cell–cell adhesion molecule N-cadherin (Ncad) is associated with highly aggressive cancers, and its expression by osteogenic
Externí odkaz:
https://doaj.org/article/8c504094029a430e87c87faaa1326bf6
Autor:
Vijay K Samineni, Jose G Grajales-Reyes, Gary E Grajales-Reyes, Eric Tycksen, Bryan A Copits, Christian Pedersen, Edem S Ankudey, Julian N Sackey, Sienna B Sewell, Michael R Bruchas, Robert W Gereau
Publikováno v:
eLife, Vol 10 (2021)
Itch is an unpleasant sensation that elicits robust scratching and aversive experience. However, the identity of the cells and neural circuits that organize this information remains elusive. Here, we show the necessity and sufficiency of chloroquine-
Externí odkaz:
https://doaj.org/article/577ca76edf784ff79d2ca897c084ec3a
Autor:
Tusar Giri, Jia Jiang, Zhiqiang Xu, Ronald McCarthy, Carmen M. Halabi, Eric Tycksen, Alison G. Cahill, Sarah K. England, Arvind Palanisamy
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/30a1f38063dd469f812b17e865c82659