ADP ribosylation factor like 2 (Arl2) regulates breast tumor aggressivity in immunodeficient mice.

Autor: Anne Beghin, Stéphane Belin, Rouba Hage-Sleiman, Stéphanie Brunet Manquat, Sophie Goddard, Eric Tabone, Lars P Jordheim, Isabelle Treilleux, Marie-France Poupon, Jean-Jacques Diaz, Charles Dumontet

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7478 (2009)

We have previously reported that ADP ribosylation factor like 2 (Arl2), a small GTPase, content influences microtubule dynamics and cell cycle distribution in breast tumor cells, as well as the degree and distribution of phosphorylated P53. Here we s

Externí odkaz: https://doaj.org/article/2e159abbf12f4af18f45bfe0c66c546d

Malignant transformation of a rat fibroma by the treatment with an anti-fibrosing drug: CY-168F (Plastenan)

Autor: Sonia G. Andrade, Jean Alexis Grimaud, Eric Tabone, Manoel Barral Netto

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 76, Iss 3, Pp 259-268 (1981)

Fifteen albino (Sprague Dawley) rats with subcutaneous transplanted fibromas was used in the present study. The tumour was formed by typical fibroblasts in a dense collagen matrix and was provenient from a fibroma that appeared spontaneously in an al

Externí odkaz: https://doaj.org/article/340dcd253b2e46b6b5f092ab218791b5

KIT Mutations Induce Intracellular Retention and Activation of an Immature Form of the KIT Protein in Gastrointestinal Stromal Tumors

Autor: Jean-François Emile, Jean-Philippe Michot, Séverine Tabone-Eglinger, Laurent Alberti, Nathalie Théou-Anton, Antoinette Lemoine, Jean-Yves Blay, Hiba El Sayadi, Eric Tabone, Frédéric Subra

Publikováno v: Clinical Cancer Research
Clinical Cancer Research, American Association for Cancer Research, 2008, 14 (8), pp.2285-94. ⟨10.1158/1078-0432.CCR-07-4102⟩

Purpose: Gastrointestinal stromal tumors (GIST) are frequently associated with gain-of-function mutations of KIT, which can be inhibited by imatinib both in vitro and in vivo. The survival of patients with GIST, following imatinib therapy, has been c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95a8cdc6127201b3f93aafdf690e27c
https://doi.org/10.1158/1078-0432.ccr-07-4102

Alteration of Transforming Growth Factor-β Signaling System Expression in Adult Rat Germ Cells with a Chronic Apoptotic Cell Death Process after Fetal Androgen Disruption

Autor: Claire Mauduit, Eric Tabone, Krisztian Kaszas, Daniel Regnier, Pierre Contard, Magali Maire, Remi Bars, Anne Florin, Mohamed Benahmed

Publikováno v: Endocrinology. 146:5135-5143

In utero exposure to chemicals with antiandrogen activity induces undescended testis, hypospadias, and sub- or infertility. The hypospermatogenesis observed in the adult rat testis exposed in utero to the antiandrogen flutamide has been reported to b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c7307048538f6ecf2f1af37dd4d8b1
https://doi.org/10.1210/en.2005-0592

α6 integrin subunit mediates laminin enhancement of cisplatin-induced apoptosis in testicular tumor germ cells

Autor: Maoulana Andjilani, Jean-Pierre Droz, Mohamed Benahmed, Eric Tabone

Publikováno v: International Journal of Cancer. 117:68-81

Our study demonstrates that laminin potentiates cisplatin-induced apoptosis in NCCIT, a testicular tumor germ cell line. When cultured on laminin, NCCIT cells displayed a significantly higher susceptibility to cisplatin-induced apoptosis than on plas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317522ce0d947239739a6a1aff12d2b4
https://doi.org/10.1002/ijc.21144