Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Eric T. Whalley"'
Autor:
Barry Ticho, Eman M. Salah, Aaron Deykin, Eric T. Whalley, Glenn J. Smits, Stevan P. Tofovic, Edwin K. Jackson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 356:333-340
Heart failure with preserved ejection fraction (HFpEF) is prevalent and often accompanied by metabolic syndrome. Current treatment options are limited. Here, we test the hypothesis that combined A1/A2B adenosine receptor blockade is beneficial in obe
Autor:
Juerg Nussberger, Jane K. Relton, Werner Müller-Esterl, Klaus Zweckberger, Nikolaus Plesnila, Raimund Trabold, Michael Bader, Christian Erös, Eric T. Whalley, Heike Beck
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 30:130-139
Inflammatory mechanisms are known to contribute to the pathophysiology of traumatic brain injury (TBI). Since bradykinin is one of the first mediators activated during inflammation, we investigated the role of bradykinin and its receptors in posttrau
Publikováno v:
American Journal of Nephrology. 30:521-526
Background/Aims: Cisplatin (CIS) induces nephrotoxicity partly through renal vasoconstriction and decreased glomerular filtration effects thought to involve adenosine acting on adenosine A1 receptors (A1Rs). We studied the effect of the orally active
Autor:
Mark Cornebise, C. Nickerson-Nutter, Brian M. Dolinski, Stuart J. Perper, Steve Adams, Alan Gill, Diane R Leone, Doreen Lepage, Keith Giza, R. B. Pepinsky, L. L. Chen, Eric T. Whalley, Roy R. Lobb, K. Wortham, Petter Russell C, Daniel Scott, Wen-Cherng Lee, A. Chakraborty
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:742-750
Integrin alpha4beta1 plays an important role in inflammatory processes by regulating the migration of leukocytes into inflamed tissues. Previously, we identified BIO5192 [2(S)-{[1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2(S)-carbonyl]-amino}-4-[4-
Autor:
Frank Lutterodt, Xiaowei Jin, Eric T. Whalley, Glenn Smits, Barry Ticho, Alan Gill, John A. Auchampach
Publikováno v:
Drug Development Research. 58:486-492
Stimulation of A 1 adenosine receptors in the kidney reduces glomerular filtration rate (GFR) via tubuloglomerular feedback and increases sodium reabsorption. Blocking A 1 adenosine receptors would therefore maintain GFR and cause natriuresis. These
Autor:
Roy R. Lobb, Mark Cornebise, Russell C. Petter, C. Nickerson-Nutter, K. Wortham, Doreen Lepage, R. B. Pepinsky, Wen-Cherng Lee, Steve Adams, L. L. Chen, Daniel Scott, J. C. Spell, Brian M. Dolinski, Alan Gill, W. Yang, Keith Giza, Stuart J. Perper, Eric T. Whalley, Diane R Leone
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 305:1150-1162
Integrin alpha 4 beta 1 plays an important role in inflammatory processes by regulating the migration of lymphocytes into inflamed tissues. Here we evaluated the biochemical, pharmacological, and pharmacodynamic properties and efficacy in experimenta
Publikováno v:
Stroke. 32:199-205
Background and Purpose —The present study was performed to determine the role of α4 (CD49d), a member of the integrin family of adhesion molecules, in ischemic brain pathology. Methods —Male spontaneously hypertensive rats (SHR) or Sprague-Dawle
Autor:
Michael Burkard, Val S. Goodfellow, Mary Francis, Manoj V. Marathe, Lajos Gera, Sherman E. Ross, Maciej Wieczorek, Timothy D. Fitzpatrick, Lyle W. Spruce, Steven W. Jones, Albert Gyorkos, John M. Stewart, Eric T. Whalley, John S. Zuzack, William M. Selig, Virginia E. Beckey, Anna Pilyavskaya
Publikováno v:
Biochemical Pharmacology. 54:283-291
The determination of the relationship between ligand affinity and bioactivity is important for the understanding of receptor function in biological systems and for drug development. Several physiological and pathophysiological functions of bradykinin
Autor:
D F Dyckes, M R Burkard, J K Blodgett, John S. Zuzack, Eric T. Whalley, H B Kroona, S E Ross, A H Leimer, D L Gernert
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 75:633-638
Les maladies inflammatoires ont generalement une etiologie complexe et mettent en jeu une multitude de mediateurs; il semblerait donc approprie de les considerer en utilisant une approche polytherapeutique. Dans certaines conditions inflammatoires ch
Autor:
Matthias Siebeck, Hans Fritz, Michael Fautz, Eric T. Whalley, Sabine Eich-Rathfelder, Felix Hohenbleicher
Publikováno v:
Immunopharmacology. 36:173-177
Previous experiments in anesthetized pigs have demonstrated that blockade of the bradykinin B2 receptor in experimental endotoxin shock attenuates LPS-induced organ failure, lung dysfunction and mortality. Additional B1 receptor blockade in this situ