Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Eric T. Clambey"'
Autor:
Emily K. Kleczko, Trista K. Hinz, Teresa T. Nguyen, Natalia J. Gurule, Andre Navarro, Anh T. Le, Amber M. Johnson, Jeff Kwak, Diana I. Polhac, Eric T. Clambey, Mary Weiser-Evans, Daniel T. Merrick, Michael C. Yang, Tejas Patil, Erin L. Schenk, Lynn E. Heasley, Raphael A. Nemenoff
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract Lung cancers bearing oncogenic EML4-ALK fusions respond to targeted tyrosine kinase inhibitors (TKIs; e.g., alectinib), with variation in the degree of shrinkage and duration of treatment (DOT). However, factors that control this response ar
Externí odkaz:
https://doaj.org/article/8192c462eff74d50be9a1f7314bb046e
Autor:
Emily K. Kleczko, Dustin T. Nguyen, Kenneth H. Marsh, Colin D. Bauer, Amy S. Li, Marie-Louise T. Monaghan, Michael D. Berger, Seth B. Furgeson, Berenice Y. Gitomer, Michel B. Chonchol, Eric T. Clambey, Kurt A. Zimmerman, Raphael A. Nemenoff, Katharina Hopp
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Innate and adaptive immune cells modulate the severity of autosomal dominant polycystic kidney disease (ADPKD), a common kidney disease with inadequate treatment options. ADPKD has parallels with cancer, in which immune checkpoint inhibitors have bee
Externí odkaz:
https://doaj.org/article/db0e24d1120a4e91b18a5137cdd01738
Autor:
Dustin T. Nguyen, Emily K. Kleczko, Nidhi Dwivedi, Marie-Louise T. Monaghan, Berenice Y. Gitomer, Michel B. Chonchol, Eric T. Clambey, Raphael A. Nemenoff, Jelena Klawitter, Katharina Hopp
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic nephropathy, is characterized by phenotypic variability that exceeds genic effects. Dysregulated metabolism and immune cell function are key disease modifiers. The trypto
Externí odkaz:
https://doaj.org/article/309833323f31402ebb2adcd39a55bdfc
Autor:
Sean P. Korpela, Trista K. Hinz, Ayman Oweida, Jihye Kim, Jacob Calhoun, Robert Ferris, Raphael A. Nemenoff, Sana D. Karam, Eric T. Clambey, Lynn E. Heasley
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background Epidermal growth factor receptor (EGFR) is frequently amplified or overexpressed in head and neck squamous cell carcinoma (HNSCC) and is a clinically validated target for the therapeutic antibody, cetuximab, in the management of t
Externí odkaz:
https://doaj.org/article/6d59c8e01ce041bf87fdfd079c2692c1
Autor:
Julianne B. Riggs, Eva M. Medina, Loni J. Perrenoud, Diana L. Bonilla, Eric T. Clambey, Linda F. van Dyk, Leslie J. Berg
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Investigating the dynamics of virus-host interactions in vivo remains an important challenge, often limited by the ability to directly identify virally infected cells. Here, we utilize a beta-lactamase activated fluorescent substrate to identify prim
Externí odkaz:
https://doaj.org/article/a5d65b88875f488e82aa0fae07cd233b
Autor:
Louis Cicchini, Joseph A. Westrich, Tao Xu, Daniel W. Vermeer, Jennifer N. Berger, Eric T. Clambey, Denis Lee, John I. Song, Paul F. Lambert, Robert O. Greer, John H. Lee, Dohun Pyeon
Publikováno v:
mBio, Vol 7, Iss 3 (2016)
ABSTRACT High-risk human papillomaviruses (HPVs) are causally associated with multiple human cancers. Previous studies have shown that the HPV oncoprotein E7 induces immune suppression; however, the underlying mechanisms remain unknown. To understand
Externí odkaz:
https://doaj.org/article/968814f4f50343f0bc8be64a70db166d
Autor:
Kevin W. Diebel, Lauren M. Oko, Eva M. Medina, Brian F. Niemeyer, Cody J. Warren, David J. Claypool, Scott A. Tibbetts, Carlyne D. Cool, Eric T. Clambey, Linda F. van Dyk
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
ABSTRACT Many viruses express noncoding RNAs (ncRNAs). The gammaherpesviruses (γHVs), including Epstein-Barr virus, Kaposi’s sarcoma-associated herpesvirus, and murine γHV68, each contain multiple ncRNA genes, including microRNAs (miRNAs). While
Externí odkaz:
https://doaj.org/article/b949fbeb6ede4d07999a559993d6083a
Autor:
Laurel B. Darragh, Michael M. Knitz, Junxiao Hu, Eric T. Clambey, Jennifer Backus, Andrew Dumit, Von Samedi, Andrew Bubak, Casey Greene, Timothy Waxweiler, Sanjana Mehrotra, Shilpa Bhatia, Jacob Gadwa, Thomas Bickett, Miles Piper, Kareem Fakhoury, Arthur Liu, Joshua Petit, Daniel Bowles, Ashesh Thaker, Kimberly Atiyeh, Julie Goddard, Robert Hoyer, Adrie Van Bokhoven, Kimberly Jordan, Antonio Jimeno, Angelo D’Alessandro, David Raben, Jessica D. McDermott, Sana D. Karam
Publikováno v:
Nature Cancer. 3:1300-1317
Five-year survival for human papilloma virus-unrelated head and neck squamous cell carcinomas remain below 50%. We assessed the safety of administering combination hypofractionated stereotactic body radiation therapy with single-dose durvalumab (anti
Autor:
Raphael A. Nemenoff, Eric T. Clambey, Mary C. Weiser-Evans, Lynn E. Heasley, Trisha R. Sippel, Joanna M. Poczobutt, Jeff Kwak, Teresa T. Nguyen, Bonnie Bullock, Maria McSharry, Howard Y. Li
Flow cytometry gating strategy for identifying CD4+ and CD8+ T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ceb30405e4269cfdd72ebad700454df
https://doi.org/10.1158/2326-6066.22539158
https://doi.org/10.1158/2326-6066.22539158
Autor:
Raphael A. Nemenoff, Eric T. Clambey, Mary C. Weiser-Evans, Lynn E. Heasley, Trisha R. Sippel, Joanna M. Poczobutt, Jeff Kwak, Teresa T. Nguyen, Bonnie Bullock, Maria McSharry, Howard Y. Li
Flow gating strategy for identification of PD-L1(high) cells in the TME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125f3aeb8354c9b5590ddb2cf7087153
https://doi.org/10.1158/2326-6066.22539164
https://doi.org/10.1158/2326-6066.22539164