Výsledky vyhledávání - "Eric T Clambey"

Akademický článek

The gammaherpesvirus 68 viral cyclin facilitates expression of LANA.

Autor: Brian F Niemeyer, Bridget Sanford, Joy E Gibson, Jennifer N Berger, Lauren M Oko, Eva Medina, Eric T Clambey, Linda F van Dyk

Publikováno v: PLoS Pathogens, Vol 17, Iss 11, p e1010019 (2021)

Gammaherpesviruses establish life-long infections within their host and have been shown to be the causative agents of devastating malignancies. Chronic infection within the host is mediated through cycles of transcriptionally quiescent stages of late

Externí odkaz: https://doaj.org/article/9de3c67c9b8e4b4dafad6081faeabaa1

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Akademický článek

Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)

Background Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate the

Externí odkaz: https://doaj.org/article/cbf79a9cbfcd4744b19d4b8a1b088264

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Akademický článek

Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression.

Autor: Lauren M Oko, Abigail K Kimball, Rachael E Kaspar, Ashley N Knox, Carrie B Coleman, Rosemary Rochford, Tim Chang, Benjamin Alderete, Linda F van Dyk, Eric T Clambey

Publikováno v: PLoS Pathogens, Vol 15, Iss 6, p e1007849 (2019)

Virus-host interactions are frequently studied in bulk cell populations, obscuring cell-to-cell variation. Here we investigate endogenous herpesvirus gene expression at the single-cell level, combining a sensitive and robust fluorescent in situ hybri

Externí odkaz: https://doaj.org/article/bac2e87bf14243709af7a93ebfc389cd

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Akademický článek

The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.

Autor: Eric T Clambey, Bernard Collins, Mary H Young, Jens Eberlein, Alexandria David, John W Kappler, Philippa Marrack

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57435 (2013)

The Ikaros family of transcription factors is critical for normal T cell development while limiting malignant transformation. Mature CD8 T cells express multiple Ikaros family members, yet little is known about their function in this context. To test

Externí odkaz: https://doaj.org/article/1a2a32c056b147608c4943d1c861a41a

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Akademický článek

Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation.

Autor: Heidi Ehrentraut, Joseph A Westrich, Holger K Eltzschig, Eric T Clambey

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32416 (2012)

Anti-inflammatory signals play an essential role in constraining the magnitude of an inflammatory response. Extracellular adenosine is a critical tissue-protective factor, limiting the extent of inflammation. Given the potent anti-inflammatory effect

Externí odkaz: https://doaj.org/article/4ba6b2ba679c42a9aabebe28550902ae

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