Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Eric T Clambey"'
Autor:
Brian F Niemeyer, Bridget Sanford, Joy E Gibson, Jennifer N Berger, Lauren M Oko, Eva Medina, Eric T Clambey, Linda F van Dyk
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010019 (2021)
Gammaherpesviruses establish life-long infections within their host and have been shown to be the causative agents of devastating malignancies. Chronic infection within the host is mediated through cycles of transcriptionally quiescent stages of late
Externí odkaz:
https://doaj.org/article/9de3c67c9b8e4b4dafad6081faeabaa1
Autor:
Eric T Clambey, Jacob Gadwa, Thomas E Bickett, Laurel B Darragh, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Sana D Karam, Michael W Knitz, Ayman J Oweida, Adam C Mueller, Douglas G Osborne, Xiyuan Bai, Sarah E Ferrara, Mary-Keara Boss, Andrew Goodspeed, Matthew A Burchill, Beth A Jirón Tamburini, Edward D Chan, Curtis R Pickering
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate the
Externí odkaz:
https://doaj.org/article/cbf79a9cbfcd4744b19d4b8a1b088264
Autor:
Alexander J Neuwelt, Abigail K Kimball, Amber M Johnson, Benjamin W Arnold, Bonnie L Bullock, Rachael E Kaspar, Emily K Kleczko, Jeff W Kwak, Meng-Han Wu, Lynn E Heasley, Robert C Doebele, Howard Y Li, Raphael A Nemenoff, Eric T Clambey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Programmed death 1/programmed death ligand 1 (PD-1/PD-L1) targeted immunotherapy affords clinical benefit in ~20% of unselected patients with lung cancer. The factor(s) that determine whether a tumor responds or fails to respond to immunot
Externí odkaz:
https://doaj.org/article/392478c81db649bab2de6e5e9eb696a8
Autor:
Lauren M Oko, Abigail K Kimball, Rachael E Kaspar, Ashley N Knox, Carrie B Coleman, Rosemary Rochford, Tim Chang, Benjamin Alderete, Linda F van Dyk, Eric T Clambey
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007849 (2019)
Virus-host interactions are frequently studied in bulk cell populations, obscuring cell-to-cell variation. Here we investigate endogenous herpesvirus gene expression at the single-cell level, combining a sensitive and robust fluorescent in situ hybri
Externí odkaz:
https://doaj.org/article/bac2e87bf14243709af7a93ebfc389cd
Autor:
Eric T Clambey, Bernard Collins, Mary H Young, Jens Eberlein, Alexandria David, John W Kappler, Philippa Marrack
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57435 (2013)
The Ikaros family of transcription factors is critical for normal T cell development while limiting malignant transformation. Mature CD8 T cells express multiple Ikaros family members, yet little is known about their function in this context. To test
Externí odkaz:
https://doaj.org/article/1a2a32c056b147608c4943d1c861a41a
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32416 (2012)
Anti-inflammatory signals play an essential role in constraining the magnitude of an inflammatory response. Extracellular adenosine is a critical tissue-protective factor, limiting the extent of inflammation. Given the potent anti-inflammatory effect
Externí odkaz:
https://doaj.org/article/4ba6b2ba679c42a9aabebe28550902ae
Autor:
Emily K. Kleczko, Trista K. Hinz, Teresa T. Nguyen, Natalia J. Gurule, Andre Navarro, Anh T. Le, Amber M. Johnson, Jeff Kwak, Diana I. Polhac, Eric T. Clambey, Mary Weiser-Evans, Daniel T. Merrick, Michael C. Yang, Tejas Patil, Erin L. Schenk, Lynn E. Heasley, Raphael A. Nemenoff
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract Lung cancers bearing oncogenic EML4-ALK fusions respond to targeted tyrosine kinase inhibitors (TKIs; e.g., alectinib), with variation in the degree of shrinkage and duration of treatment (DOT). However, factors that control this response ar
Externí odkaz:
https://doaj.org/article/8192c462eff74d50be9a1f7314bb046e
Autor:
Emily K. Kleczko, Dustin T. Nguyen, Kenneth H. Marsh, Colin D. Bauer, Amy S. Li, Marie-Louise T. Monaghan, Michael D. Berger, Seth B. Furgeson, Berenice Y. Gitomer, Michel B. Chonchol, Eric T. Clambey, Kurt A. Zimmerman, Raphael A. Nemenoff, Katharina Hopp
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Innate and adaptive immune cells modulate the severity of autosomal dominant polycystic kidney disease (ADPKD), a common kidney disease with inadequate treatment options. ADPKD has parallels with cancer, in which immune checkpoint inhibitors have bee
Externí odkaz:
https://doaj.org/article/db0e24d1120a4e91b18a5137cdd01738
Autor:
Dustin T. Nguyen, Emily K. Kleczko, Nidhi Dwivedi, Marie-Louise T. Monaghan, Berenice Y. Gitomer, Michel B. Chonchol, Eric T. Clambey, Raphael A. Nemenoff, Jelena Klawitter, Katharina Hopp
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic nephropathy, is characterized by phenotypic variability that exceeds genic effects. Dysregulated metabolism and immune cell function are key disease modifiers. The trypto
Externí odkaz:
https://doaj.org/article/309833323f31402ebb2adcd39a55bdfc
Autor:
Laurel B. Darragh, Michael M. Knitz, Junxiao Hu, Eric T. Clambey, Jennifer Backus, Andrew Dumit, Von Samedi, Andrew Bubak, Casey Greene, Timothy Waxweiler, Sanjana Mehrotra, Shilpa Bhatia, Jacob Gadwa, Thomas Bickett, Miles Piper, Kareem Fakhoury, Arthur Liu, Joshua Petit, Daniel Bowles, Ashesh Thaker, Kimberly Atiyeh, Julie Goddard, Robert Hoyer, Adrie Van Bokhoven, Kimberly Jordan, Antonio Jimeno, Angelo D’Alessandro, David Raben, Jessica D. McDermott, Sana D. Karam
Publikováno v:
Nature Cancer. 3:1300-1317
Five-year survival for human papilloma virus-unrelated head and neck squamous cell carcinomas remain below 50%. We assessed the safety of administering combination hypofractionated stereotactic body radiation therapy with single-dose durvalumab (anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629377889c7c9cf5ce0c51a52febe8f7
https://doi.org/10.1038/s43018-022-00450-6
https://doi.org/10.1038/s43018-022-00450-6