Zobrazeno 1 - 10
of 391
pro vyhledávání: '"Eric T, Kool"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Methods for fluorescently labelling DNAs are expensive and labour-intensive. Here the authors report an in situ DNA labelling strategy for oligonucleotides as well as dsDNA that makes use of aldehyde-reactive rotor dyes to trap AP sites resulting fro
Externí odkaz:
https://doaj.org/article/7ba6e6d9bdcf4817a8b92421226d6b59
Autor:
Ru-Yi Zhu, Chandrima Majumdar, Cindy Khuu, Mariarosaria De Rosa, Patricia L. Opresko, Sheila S. David, Eric T. Kool
Publikováno v:
ACS Central Science, Vol 6, Iss 10, Pp 1735-1742 (2020)
Externí odkaz:
https://doaj.org/article/b83d1007b30843a0aba07520da049229
Autor:
Ling Zhang, Laura Misiara, Govindi J. Samaranayake, Nisha Sharma, Dao M. Nguyen, Yu-Ki Tahara, Eric T. Kool, Priyamvada Rai
Publikováno v:
Redox Biology, Vol 40, Iss , Pp 101848- (2021)
Cancer cells develop protective adaptations against oxidative DNA damage, providing a strong rationale for targeting DNA repair proteins. There has been a high degree of recent interest in inhibiting the mammalian Nudix pyrophosphatase MutT Homolog 1
Externí odkaz:
https://doaj.org/article/731941f3c3714aa9adb34e60d80e9306
Publikováno v:
ACS Central Science. 9:531-539
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a768c18ba3525bf16f7e9cc64f133daa
https://doi.org/10.1021/acscentsci.2c01237
https://doi.org/10.1021/acscentsci.2c01237
Publikováno v:
Journal of the American Chemical Society. 145:143-151
RNA 2'-OH acylation is widely used both for mapping structure and for conjugating RNA, generally relying on selective reactions with unpaired nucleotides over paired ones. Common reagents for this acylation have been chiefly restricted to two similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b2251f1c12eecf6b24dd83a780cc64
https://doi.org/10.1021/jacs.2c09040
https://doi.org/10.1021/jacs.2c09040
Autor:
Yujeong Lee, Yoshiyuki Onishi, Lisa McPherson, Anna M. Kietrys, Marian Hebenbrock, Yong Woong Jun, Ishani Das, Shanthi Adimoolam, Debin Ji, Michael G. Mohsen, James M. Ford, Eric T. Kool
Publikováno v:
ACS Chemical Biology. 17:2074-2087
Impaired DNA repair activity has been shown to greatly increase rates of cancer clinically. It has been hypothesized that upregulating repair activity in susceptible individuals may be a useful strategy for inhibiting tumorigenesis. Here, we report t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a752122c9007342d181d33a1590b96c
https://doi.org/10.1021/acschembio.2c00038
https://doi.org/10.1021/acschembio.2c00038
Autor:
Priyamvada Rai, Eric T. Kool, Antonio Barrientos, Marcus S. Cooke, Mahsa Karbaschi, David J. Robbins, Dao M. Nguyen, Yoshiyuki Onishi, Lisa McPherson, Debin Ji, Christina J. Jayaraj, Mai Huynh, Ling Zhang, Clara I. Troccoli, Govindi J. Samaranayake
Supplementary legends and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ae6c4c5262686816c60f64ad2fc910
https://doi.org/10.1158/1535-7163.22506834.v1
https://doi.org/10.1158/1535-7163.22506834.v1
Autor:
Zachary D Nagel, Andrew A Beharry, Patrizia Mazzucato, Gaspar J Kitange, Jann N Sarkaria, Eric T Kool, Leona D Samson
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0208341 (2019)
The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) strongly influences the effectiveness of cancer treatment with chemotherapeutic alkylating agents, and MGMT status in cancer cells could potentially contribute to tailored therapies
Externí odkaz:
https://doaj.org/article/6cb244a315884924966a4e8becf14c02
Autor:
Linglan Fang, Willem A Velema, Yujeong Lee, Lu Xiao, Michael G Mohsen, Anna M Kietrys, Eric T Kool
The off-target toxicity of drugs targeted to proteins imparts substantial health and economic costs. Proteome interaction studies can reveal off-target effects with unintended proteins; however, little attention has been paid to intracellular RNAs as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4be11dd43ceee6ee2d4b218a5e8be56
https://doi.org/10.1101/2022.07.18.500496
https://doi.org/10.1101/2022.07.18.500496
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::588da7a64dbee2b7befe9d23ad7e4910
https://doi.org/10.1096/fasebj.2022.36.s1.l7412
https://doi.org/10.1096/fasebj.2022.36.s1.l7412