Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Eric Spierings"'
Autor:
Benedict M. Matern, Eric Spierings, Selle Bandstra, Abeer Madbouly, Stefan Schaub, Eric T. Weimer, Matthias Niemann
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
IntroductionModern histocompatibility algorithms depend on the comparison and analysis of high-resolution HLA protein sequences and structures, especially when considering epitope-based algorithms, which aim to model the interactions involved in anti
Externí odkaz:
https://doaj.org/article/837d41c767274cfdaaea7944fce232b1
Autor:
Gautam Kok, MD, PhD, Eveline F. Ilcken, MSc, Roderick H.J. Houwen, MD, PhD, Caroline A. Lindemans, MD, PhD, Edward E.S. Nieuwenhuis, MD, PhD, Eric Spierings, PhD, Sabine A. Fuchs, MD, PhD
Publikováno v:
Annals of Surgery Open, Vol 4, Iss 3, p e334 (2023)
Objective:. We aim to investigate the effects of genetically based HLA matching on patient and graft survival, and acute and chronic rejection after liver transplantation Background:. Liver transplantation is a common treatment for patients with end-
Externí odkaz:
https://doaj.org/article/b77e2674970448f99891cba5a9969236
Autor:
Gerdien Mijnheer, Nila Hendrika Servaas, Jing Yao Leong, Arjan Boltjes, Eric Spierings, Phyllis Chen, Liyun Lai, Alessandra Petrelli, Sebastiaan Vastert, Rob J de Boer, Salvatore Albani, Aridaman Pandit, Femke van Wijk
Publikováno v:
eLife, Vol 12 (2023)
Autoimmune inflammation is characterized by tissue infiltration and expansion of antigen-specific T cells. Although this inflammation is often limited to specific target tissues, it remains yet to be explored whether distinct affected sites are infil
Externí odkaz:
https://doaj.org/article/7571fb8d41c545a59ee5ff9879ec1345
Autor:
Matthias Niemann, Yara Strehler, Nils Lachmann, Fabian Halleck, Klemens Budde, Gideon Hönger, Stefan Schaub, Benedict M. Matern, Eric Spierings
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Development of donor-specific human leukocyte antigen (HLA) antibodies (DSA) remains a major risk factor for graft loss following organ transplantation, where DSA are directed towards patches on the three-dimensional structure of the respective organ
Externí odkaz:
https://doaj.org/article/bbd636c2afcf480f920489f8af6db569
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The role of the indirect T-cell recognition pathway of allorecognition in acute T cell-mediated rejection (aTCMR) is not well defined. The amount of theoretical T-cell epitopes available for indirect allorecognition can be quantified for donor-recipi
Externí odkaz:
https://doaj.org/article/d6c04afad6ed489b89052a379c69414d
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Histocompatibility in solid-organ transplantation has a strong impact on long-term graft survival. Although recent advances in matching of both B-cell epitopes and T-cell epitopes have improved understanding of allorecognition, the immunogenic determ
Externí odkaz:
https://doaj.org/article/4aad96b447fd4081a61ee2fc3b734450
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Predicted Indirectly ReCognizable Human Leukocyte Antigen (HLA) Epitopes (PIRCHE) are known to be a significant risk factor for the development of donor HLA-specific antibodies after organ transplantation. Most previous studies on PIRCHE limited thei
Externí odkaz:
https://doaj.org/article/07b37444db6548e083a9b6a64c939cb0
Autor:
Emma T. M. Peereboom, Benedict M. Matern, Toshihide Tomosugi, Matthias Niemann, Julia Drylewicz, Irma Joosten, Wil A. Allebes, Arnold van der Meer, Luuk B. Hilbrands, Marije C. Baas, Franka E. van Reekum, Marianne C. Verhaar, Elena G. Kamburova, Marc A. J. Seelen, Jan Stephan Sanders, Bouke G. Hepkema, Annechien J. Lambeck, Laura B. Bungener, Caroline Roozendaal, Marcel G. J. Tilanus, Christien E. Voorter, Lotte Wieten, Elly M. van Duijnhoven, Mariëlle A. C. J. Gelens, Maarten H. L. Christiaans, Frans J. van Ittersum, Azam Nurmohamed, Neubury M. Lardy, Wendy Swelsen, Karlijn A. van der Pant, Neelke C. van der Weerd, Ineke J. M. ten Berge, Fréderike J. Bemelman, Aiko P. J. de Vries, Johan W. de Fijter, Michiel G. H. Betjes, Dave L. Roelen, Frans H. Claas, Henny G. Otten, Sebastiaan Heidt, Arjan D. van Zuilen, Takaaki Kobayashi, Kirsten Geneugelijk, Eric Spierings
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
CD4+ T-helper cells play an important role in alloimmune reactions following transplantation by stimulating humoral as well as cellular responses, which might lead to failure of the allograft. CD4+ memory T-helper cells from a previous immunizing eve
Externí odkaz:
https://doaj.org/article/304c2f59ef3743a597b164b0c8125533
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009248 (2021)
The EuroTransplant Kidney Allocation System (ETKAS) aims at allocating organs to patients on the waiting list fairly whilst optimizing HLA match grades. ETKAS currently considers the number of HLA-A, -B, -DR mismatches. Evidently, epitope matching is
Externí odkaz:
https://doaj.org/article/906fa0f267b24e0b8042e575073c0d4f
Autor:
Toshihide Tomosugi, Kenta Iwasaki, Shintaro Sakamoto, Matthias Niemann, Eric Spierings, Isao Nahara, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Asami Takeda, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai, Takaaki Kobayashi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In pre-sensitizing events, immunological memory is mainly created via indirect allorecognition where CD4+ T cells recognize foreign peptides in the context of self-HLA class II (pHLA) presented on antigen-presenting cells. This recognition makes it p
Externí odkaz:
https://doaj.org/article/69f868b0fa394ddaaa0c251a6b4a74e0