Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Eric Shifrut"'
Autor:
Avishai Maliah, Nadine Santana-Magal, Shivang Parikh, Sagi Gordon, Keren Reshef, Yuval Sade, Aseel Khateeb, Alon Richter, Amit Gutwillig, Roma Parikh, Tamar Golan, Matan Krissi, Manho Na, Gal Binshtok, Paulee Manich, Nadav Elkoshi, Sharon Grisaru-Tal, Valentina Zemser-Werner, Ronen Brenner, Hananya Vaknine, Eran Nizri, Lilach Moyal, Iris Amitay-Laish, Luiza Rosemberg, Ariel Munitz, Noga Kronfeld-Schor, Eric Shifrut, Oren Kobiler, Asaf Madi, Tamar Geiger, Yaron Carmi, Carmit Levy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract T cell inhibitory mechanisms prevent autoimmune reactions, while cancer immunotherapy aims to remove these inhibitory signals. Chronic ultraviolet (UV) exposure attenuates autoimmunity through promotion of poorly understood immune-suppressiv
Externí odkaz:
https://doaj.org/article/558f6188a6ba4158b35fee08d311324d
Autor:
Beatrice Claudia Cianciotti, Zulma Irene Magnani, Alessia Ugolini, Barbara Camisa, Ivan Merelli, Valentina Vavassori, Alessia Potenza, Antonio Imparato, Francesco Manfredi, Danilo Abbati, Laura Perani, Antonello Spinelli, Eric Shifrut, Fabio Ciceri, Luca Vago, Raffaella Di Micco, Luigi Naldini, Pietro Genovese, Eliana Ruggiero, Chiara Bonini
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIn adoptive T cell therapy, the long term therapeutic benefits in patients treated with engineered tumor specific T cells are limited by the lack of long term persistence of the infused cellular products and by the immunosuppressive mechani
Externí odkaz:
https://doaj.org/article/0c75a1d1ee5c498d8c626e70eae69c03
Autor:
Joseph Hiatt, Judd F. Hultquist, Michael J. McGregor, Mehdi Bouhaddou, Ryan T. Leenay, Lacy M. Simons, Janet M. Young, Paige Haas, Theodore L. Roth, Victoria Tobin, Jason A. Wojcechowskyj, Jonathan M. Woo, Ujjwal Rathore, Devin A. Cavero, Eric Shifrut, Thong T. Nguyen, Kelsey M. Haas, Harmit S. Malik, Jennifer A. Doudna, Andrew P. May, Alexander Marson, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Hiatt et al. report the knock-out of over 400 genes in primary CD4+ T cells to assess their functional role in HIV replication, finding 86 initial candidates of which 47 are validated as HIV host factors, including 23 with restrictive activity.
Externí odkaz:
https://doaj.org/article/4afe586db1e74b9e9e49556512d17fd5
Autor:
Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Jonathan Chu, Nicholas C. Love, Anastasia Tikhonova, Sergei Radaev, Xiaoping Sun, Annette Ko, Tomer Arnon, Eric Shifrut, Nir Friedman, Nan-Ping Weng, Alfred Singer, Peter D. Sun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 o
Externí odkaz:
https://doaj.org/article/2135b8948a994dbda344f75d21b684fb
Autor:
Brian R. Shy, Vivasvan S. Vykunta, Alvin Ha, Alexis Talbot, Theodore L. Roth, David N. Nguyen, Wolfgang G. Pfeifer, Yan Yi Chen, Franziska Blaeschke, Eric Shifrut, Shane Vedova, Murad R. Mamedov, Jing-Yi Jing Chung, Hong Li, Ruby Yu, David Wu, Jeffrey Wolf, Thomas G. Martin, Carlos E. Castro, Lumeng Ye, Jonathan H. Esensten, Justin Eyquem, Alexander Marson
Publikováno v:
Nat Biotechnol
Nature biotechnology, vol 41, iss 4
Nature biotechnology, vol 41, iss 4
Enhancing CRISPR-mediated site-specific transgene insertion efficiency by homology-directed repair (HDR) using high concentrations of double-stranded DNA (dsDNA) with Cas9 target sequences (CTSs) can be toxic to primary cells. Here, we develop single
Autor:
Franziska Blaeschke, Yan Yi Chen, Ryan Apathy, Zhongmei Li, Cody T. Mowery, William A. Nyberg, Angela To, Ruby Yu, Raymund Bueno, Min Cheol Kim, Ralf Schmidt, Daniel B. Goodman, Tobias Feuchtinger, Justin Eyquem, Chun Jimmie Ye, Eric Shifrut, Theodore L. Roth, Alexander Marson
Publikováno v:
Blood. 140:7404-7406
Autor:
Min Cheol Kim, Rachel Gate, David S. Lee, Andrew Lu, Erin Gordon, Eric Shifrut, Alexander Marson, Vasilis Ntranos, Chun Jimmie Ye
Differential expression analysis of scRNA-seq data is central for characterizing how experimental factors affect the distribution of gene expression. However, it remains challenging to distinguish biological and technical sources of cell-cell variabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f9e61c8e52e808370baf3810396fee1
https://doi.org/10.1101/2022.11.09.515836
https://doi.org/10.1101/2022.11.09.515836
Autor:
Dina Schneidman-Duhovny, Natalia Khuri, Guang Qiang Dong, Michael B Winter, Eric Shifrut, Nir Friedman, Charles S Craik, Kathleen P Pratt, Pedro Paz, Fred Aswad, Andrej Sali
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206654 (2018)
Accurate predictions of T-cell epitopes would be useful for designing vaccines, immunotherapies for cancer and autoimmune diseases, and improved protein therapies. The humoral immune response involves uptake of antigens by antigen presenting cells (A
Externí odkaz:
https://doaj.org/article/7669ab41e79446a5a678b9627ae1f550
Autor:
Asaf Madi, Asaf Poran, Eric Shifrut, Shlomit Reich-Zeliger, Erez Greenstein, Irena Zaretsky, Tomer Arnon, Francois Van Laethem, Alfred Singer, Jinghua Lu, Peter D Sun, Irun R Cohen, Nir Friedman
Publikováno v:
eLife, Vol 6 (2017)
Diversity of T cell receptor (TCR) repertoires, generated by somatic DNA rearrangements, is central to immune system function. However, the level of sequence similarity of TCR repertoires within and between species has not been characterized. Using n
Externí odkaz:
https://doaj.org/article/3937974f5c114e8194e5e132044691d1
Autor:
Franziska Blaeschke, Yan Yi Chen, Ryan Apathy, Zhongmei Li, Cody T. Mowery, William A. Nyberg, Angela To, Ruby Yu, Raymund Bueno, Min Cheol Kim, Ralf Schmidt, Daniel B. Goodman, Tobias Feuchtinger, Justin Eyquem, Chun Jimmie Ye, Eric Shifrut, Theodore L. Roth, Alexander Marson
SUMMARYChronic stimulation can cause T cell dysfunction and limit efficacy of cellular immunotherapies. CRISPR screens have nominated gene targets for engineered T cells, but improved methods are required to compare large numbers of synthetic knockin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::168f46d465c9cfad52b2b8e8995fc5ac
https://doi.org/10.1101/2022.07.27.501186
https://doi.org/10.1101/2022.07.27.501186