Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Eric Sekyere"'
Autor:
Belamy B. Cheung, Ritu Mittra, Jayne Murray, Qian Wang, Janith A. Seneviratne, Mukesh Raipuria, Iris Poh Ling Wong, David Restuccia, Andrew Gifford, Alice Salib, Selina Sutton, Libby Huang, Parisa Vahidi Ferdowsi, Joanna Tsang, Eric Sekyere, Chelsea Mayoh, Lin Luo, Darren L. Brown, Jennifer L. Stow, Shizhen Zhu, Richard J. Young, Benjamin J. Solomon, Stephane Chappaz, Benjamin Kile, Andrew Kueh, Marco J. Herold, Douglas J. Hilton, Tao Liu, Murray D. Norris, Michelle Haber, Daniel R. Carter, Michael W. Parker, Glenn M. Marshall
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract MYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to gene
Externí odkaz:
https://doaj.org/article/7aab45a11a28499aa2b12d59ee58078b
Autor:
Glenn M Marshall, Pei Y Liu, Samuele Gherardi, Christopher J Scarlett, Antonio Bedalov, Ning Xu, Nuncio Iraci, Emanuele Valli, Dora Ling, Wayne Thomas, Margo van Bekkum, Eric Sekyere, Kacper Jankowski, Toby Trahair, Karen L Mackenzie, Michelle Haber, Murray D Norris, Andrew V Biankin, Giovanni Perini, Tao Liu
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002135 (2011)
The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc expression. N-Myc protein is stabilized when phosphorylated at Serine 62 by phosphorylated ERK
Externí odkaz:
https://doaj.org/article/540a116698744d01b5e6204be81788da
Autor:
Michelle Haber, Glenn M. Marshall, Susan K. Gilmour, Allen Buxton, Wendy B. London, Nicola Venn, Rosemary Sutton, Janice Smith, Jayne Murray, Ngan Ching Cheng, Wayne Thomas, Joanna Keating, Eric Sekyere, Huaqing Zhao, Rong Guo, Bruce Pawel, Candace S. Hayes, Nicholas F. Evageliou, Xueyuan Liu, Kimberly Davis, Murray D. Norris, Michael D. Hogarty
Supplementary Figure 3 from ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700c4d77b427e6efa78dc9e53bc001dd
https://doi.org/10.1158/0008-5472.22373888
https://doi.org/10.1158/0008-5472.22373888
Autor:
Michelle Haber, Glenn M. Marshall, Susan K. Gilmour, Allen Buxton, Wendy B. London, Nicola Venn, Rosemary Sutton, Janice Smith, Jayne Murray, Ngan Ching Cheng, Wayne Thomas, Joanna Keating, Eric Sekyere, Huaqing Zhao, Rong Guo, Bruce Pawel, Candace S. Hayes, Nicholas F. Evageliou, Xueyuan Liu, Kimberly Davis, Murray D. Norris, Michael D. Hogarty
Supplementary Figure 1 from ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed06e559bbe07257326da16d3ed3ff2
https://doi.org/10.1158/0008-5472.22373894.v1
https://doi.org/10.1158/0008-5472.22373894.v1
Autor:
Michelle Haber, Glenn M. Marshall, Susan K. Gilmour, Allen Buxton, Wendy B. London, Nicola Venn, Rosemary Sutton, Janice Smith, Jayne Murray, Ngan Ching Cheng, Wayne Thomas, Joanna Keating, Eric Sekyere, Huaqing Zhao, Rong Guo, Bruce Pawel, Candace S. Hayes, Nicholas F. Evageliou, Xueyuan Liu, Kimberly Davis, Murray D. Norris, Michael D. Hogarty
Neuroblastoma is a frequently lethal childhood tumor in which MYC gene deregulation, commonly as MYCN amplification, portends poor outcome. Identifying the requisite biopathways downstream of MYC may provide therapeutic opportunities. We used transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::991bf1c84c53fbb340cea38d7fea5f4c
https://doi.org/10.1158/0008-5472.c.6497243
https://doi.org/10.1158/0008-5472.c.6497243
Autor:
Michelle Haber, Glenn M. Marshall, Susan K. Gilmour, Allen Buxton, Wendy B. London, Nicola Venn, Rosemary Sutton, Janice Smith, Jayne Murray, Ngan Ching Cheng, Wayne Thomas, Joanna Keating, Eric Sekyere, Huaqing Zhao, Rong Guo, Bruce Pawel, Candace S. Hayes, Nicholas F. Evageliou, Xueyuan Liu, Kimberly Davis, Murray D. Norris, Michael D. Hogarty
Supplementary Figure Legends 1-3 from ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3025b5146eca54acb7db353f6bcb731a
https://doi.org/10.1158/0008-5472.22373885.v1
https://doi.org/10.1158/0008-5472.22373885.v1
Publikováno v:
Alternative and Complementary Therapies. 26:158-167
Diet and dietary components are known to have a direct impact on the modifiable risk factors for autoimmune disease. In this study, we review a selection of popular diets—Mediterranean, vegetarian/...
Publikováno v:
Alternative and Complementary Therapies. 26:112-118
The prevalence of autoimmune disease is estimated to outweigh the prevalence of cancer and heart disease combined and is increasing at an alarming rate. Common autoimmune diseases include, but are ...
Publikováno v:
Med Sci Educ
Currently in higher education, there is a move towards providing more student-centred learning experiences, where students are actively involved in the learning process. To promote learner engagement and communication between peers, many educators ut
Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis
Autor:
Glenn M. Marshall, Marina Pajic, Murray D. Norris, Eric Sekyere, Katleen De Preter, Belamy B. Cheung, Rani E. George, Daniel R. Carter, Michelle Haber, Selina K. Sutton, Anneleen Beckers, Jamie I. Fletcher, Jayne Murray, Franki Speleman
Publikováno v:
Molecular Oncology. 10:866-878
The MYCN gene is amplified and overexpressed in a large proportion of high stage neuroblastoma patients and has been identified as a key driver of tumorigenesis. However, the mechanism by which MYCN promotes tumor initiation is poorly understood. Her