Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Eric Schnell"'
Publikováno v:
eLife, Vol 12 (2024)
Dystroglycan (Dag1) is a transmembrane glycoprotein that links the extracellular matrix to the actin cytoskeleton. Mutations in Dag1 or the genes required for its glycosylation result in dystroglycanopathy, a type of congenital muscular dystrophy cha
Externí odkaz:
https://doaj.org/article/e565adc5784f413eb06c05992cf9eccf
Autor:
Eric Schnell, Elham Karamooz, Melanie J Harriff, Jane E Yates, Christopher D Pfeiffer, Stephen M Smith
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255123 (2021)
Coronavirus disease (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, is responsible for a global pandemic characterized by high transmissibility and morbidity. Healthcare workers (HCWs) are at
Externí odkaz:
https://doaj.org/article/1f7b983d31ba4943a09e7c197742e028
Autor:
Christina Chatzi, Yingyu Zhang, Wiiliam D Hendricks, Yang Chen, Eric Schnell, Richard H Goodman, Gary L Westbrook
Publikováno v:
eLife, Vol 8 (2019)
Exercise is a potent enhancer of learning and memory, yet we know little of the underlying mechanisms that likely include alterations in synaptic efficacy in the hippocampus. To address this issue, we exposed mice to a single episode of voluntary exe
Externí odkaz:
https://doaj.org/article/98c98939191c434cadd6f6d187a96c20
Autor:
Kunal Gupta, Eric Schnell
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0215789 (2019)
Mouse models of mesial temporal lobe epilepsy recapitulate aspects of human epilepsy, which is characterized by neuronal network remodeling in the hippocampal dentate gyrus. Observational studies suggest that this remodeling is associated with altere
Externí odkaz:
https://doaj.org/article/67b13c94e8664fd3ab45db52a82aed8a
Publikováno v:
eLife, Vol 4 (2015)
The majority of adult hippocampal newborn cells die during early differentiation from intermediate progenitors (IPCs) to immature neurons. Neural stem cells in vivo are located in a relative hypoxic environment, and hypoxia enhances their survival, p
Externí odkaz:
https://doaj.org/article/ba32d3aa7e434adda3c0d4dda502755a
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48045 (2012)
Adult-born dentate granule cells integrate into the hippocampal network, extend neurites and form synapses in otherwise mature tissue. Excitatory and inhibitory inputs innervate these new granule cells in a stereotyped, temporally segregated manner,
Externí odkaz:
https://doaj.org/article/4a1b7366ec7a4702a0eb9d6f91d43a9e
Dystroglycan (Dag1) is a transmembrane glycoprotein that links the extracellular matrix to the actin cytoskeleton. Mutations inDag1or the genes required for its glycosylation result in dystroglycanopathy, a type of congenital muscular dystrophy chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac1347e33b54b4cfdb4d55fb56b5d7e
https://doi.org/10.7554/elife.87965.1
https://doi.org/10.7554/elife.87965.1
Publikováno v:
J Neurosci
Hilar mossy cells regulate network function in the hippocampus through both direct excitation and di-synaptic inhibition of dentate granule cells (DGCs). Substantial mossy cell loss accompanies hippocampal circuit changes in epilepsy. We examined the
Publikováno v:
Journal of Neurotrauma. 38:2490-2501
Protein biomarkers are often measured at hospital presentation to diagnose traumatic brain injury (TBI) and predict patient outcomes. However, a biomarker measurement at this single time point is no more accurate at predicting patient outcomes than l
Publikováno v:
Proceedings of the National Academy of Sciences. 116:10994-10999
In temporal lobe epilepsy, sprouting of hippocampal mossy fiber axons onto dentate granule cell dendrites creates a recurrent excitatory network. However, unlike mossy fibers projecting to CA3, sprouted mossy fiber synapses depress upon repetitive ac