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Akademický článek

Lipo-chitin oligosaccharides, plant symbiosis signalling molecules that modulate mammalian angiogenesis in vitro.

Autor: Michael A Djordjevic, Anna Bezos, Susanti, Laurence Marmuse, Hugues Driguez, Eric Samain, Boris Vauzeilles, Jean-Marie Beau, Farzaneh Kordbacheh, Barry G Rolfe, Ralf Schwörer, Alison M Daines, Peter M Gresshoff, Christopher R Parish

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e112635 (2014)

Lipochitin oligosaccharides (LCOs) are signaling molecules required by ecologically and agronomically important bacteria and fungi to establish symbioses with diverse land plants. In plants, oligo-chitins and LCOs can differentially interact with dif

Externí odkaz: https://doaj.org/article/1b2a436e97f3482bae7d5d6523b8b47b

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Biotechnological production of sialylated solid lipid microparticles as inhibitors of influenza A virus infection

Autor: Emeline Richard, Aurélien Traversier, Thomas Julien, Manuel Rosa-Calatrava, Jean-Luc Putaux, Isabelle Jeacomine, Eric Samain

Publikováno v: Glycobiology
Glycobiology, 2022, ⟨10.1093/glycob/cwac054⟩

Influenza viruses bind to their target through a multivalent interaction of their hemagglutinins (HAs) with sialosides at the host cell surface. To fight the virus, one therapeutic approach consists in developing sialylated multivalent structures tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fcdc18cb612697b4a89f8abf6c0c6ac
https://cnrs.hal.science/hal-03851647/document

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Production of perdeuterated fucose from glyco-engineered bacteria

Autor: Lukas, Gajdos, V Trevor, Forsyth, Matthew P, Blakeley, Michael, Haertlein, Anne, Imberty, Eric, Samain, Juliette M, Devos

Publikováno v: Glycobiology

l-Fucose and l-fucose-containing polysaccharides, glycoproteins or glycolipids play an important role in a variety of biological processes. l-Fucose-containing glycoconjugates have been implicated in many diseases including cancer and rheumatoid arth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6dee325db62b0c1b3b3495c837ab5bf7
https://pubmed.ncbi.nlm.nih.gov/32601663

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Chemoenzymatic Syntheses of Sialylated Oligosaccharides Containing C5-Modified Neuraminic Acids for Dual Inhibition of Hemagglutinins and Neuraminidases

Autor: Eric Samain, Julio Reyes-Leyva, Sébastien Fort, Gerardo Santos-López, Lémonia Birikaki, Sylvie Armand, Hugues Driguez, Stéphanie Pradeau, Bernard Priem, Luis Márquez-Domínguez

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2015, 21 (30), pp.10903-10912. ⟨10.1002/chem.201500708⟩

A fast chemoenzymatic synthesis of sialylated oligosaccharides containing C5-modified neuraminic acids is reported. Analogues of GM3 and GM2 ganglioside saccharidic portions where the acetyl group of NeuNAc has been replaced by a phenylacetyl (PhAc)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6af5b5caa86ef980c6697c49dfbaffd
https://doi.org/10.1002/chem.201500708

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Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution

Autor: Eric Samain, Rafi Chapanian, Miriam P. Kötzler, Jayachandran N. Kizhakkedathu, Stephen G. Withers, David H. Kwan, Alisdair B. Boraston, Iren Constantinescu, Melanie A. Higgins

Publikováno v: Journal of the American Chemical Society. 137:5695-5705

Blood transfusions are critically important in many medical procedures, but the presence of antigens on red blood cells (RBCs, erythrocytes) means that careful blood-typing must be carried out prior to transfusion to avoid adverse and sometimes fatal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e68d1d8883942efa954d48a10a7669a
https://doi.org/10.1021/ja5116088

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Determining the Site of Action of Strigolactones during Nodulation

Autor: Erin L. McAdam, Noel W. Davies, Sébastien Fort, CJ Hugill, Sylvain Cottaz, Eric Samain, Eloise Foo, James B. Reid

Publikováno v: Plant Physiology
Plant Physiology, American Society of Plant Biologists, 2017, 175 (1), pp.529-542. ⟨10.1104/pp.17.00741⟩

Strigolactones (SLs) influence the ability of legumes to associate with nitrogen-fixing bacteria. In this study we determine the precise stage at which SLs influence nodulation. We show that SLs promote infection thread formation, as a null SL-defici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d18692ab8b9eb0fed0ae32405d56388
https://pubmed.ncbi.nlm.nih.gov/28751316

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Chemobacterial Synthesis of a Sialyl-Tn Cyclopeptide Vaccine Candidate

Autor: Emeline Richard, Olivier Renaudet, Eric Samain, Michele Fiore, Carlo Pifferi, Bernard Priem, Sébastien Fort, Audrey Le Gouellec

Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2017, 18 (17), pp.1730-1734. ⟨10.1002/cbic.201700240⟩
ChemBioChem, 2017, 18 (17), pp.1730-1734. ⟨10.1002/cbic.201700240⟩

International audience; A conjugatable form of the tumour-associated carbohydrate antigen sialyl-Tn (Neu5Ac-α-2,6-GalNAc) was efficiently produced in Escherichia coli. Metabolically engineered E. coli strains overexpressing the 6-sialyltransferase g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e7f5d660466ce14f3be7914a69c42d
https://pubmed.ncbi.nlm.nih.gov/28632300

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Efficient Conjugation of Oligosaccharides to Polymer Particles through Furan/Maleimide Diels-Alder Reaction: Application to the Capture of Carbohydrate-Binding Proteins

Autor: Eric Samain, Stéphanie Pradeau, Sébastien Fort, Sami Halila, Antoine Petrelli

Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2017, 18 (2), pp.206-212. ⟨10.1002/cbic.201600509⟩
ChemBioChem, 2017, 18 (2), pp.206-212. ⟨10.1002/cbic.201600509⟩

International audience; Glycan-protein interactions play a crucial role in physiological and pathological events. Hence, improving the isolation of carbohydrate-binding proteins (i.e. lectins and anti-glycan antibodies) from complex media can not onl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f44fcca453692aceec7a62adfcecb63
https://hal.archives-ouvertes.fr/hal-02115628/document

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Chemoselective coupling of sugar oximes and α-ketoacids to glycosyl amides and N-glycopeptides

Autor: Ramona Hilpert, Claudia Pöhner, Carlo Unverzagt, Vera Ullmann, Eric Samain

Publikováno v: Tetrahedron Letters. 55:2197-2200

The reaction of unprotected sugar hydroxylamines and oximes with α-ketoacids leads to the chemoselective formation of glycosyl amides following the decarboxylative condensation pathway of Bode’s ketoacid hydroxylamine (KAHA) ligation. Sugar oximes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::768f9acf4b9bcc1990905b5ea9cdb2f8
https://doi.org/10.1016/j.tetlet.2014.02.056

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Nod Factor Effects on Root Hair-Specific Transcriptome of Medicago truncatula: Focus on Plasma Membrane Transport Systems and Reactive Oxygen Species Networks

Publikováno v: Frontiers in Plant Science
Frontiers in Plant Science, Frontiers, 2016, 7, pp.794. ⟨10.3389/fpls.2016.00794⟩
Frontiers in Plant Science, Frontiers, 2015, 7, pp.794. ⟨10.3389/fpls.2016.00794⟩
Frontiers in Plant Science (7), 794. (2016)
Frontiers in Plant Science, Vol 7 (2016)
Frontiers in Plant Science, 2016, 7, pp.794. ⟨10.3389/fpls.2016.00794⟩

International audience; Root hairs are involved in water and nutrient uptake, and thereby in plant autotrophy. In legumes, they also play a crucial role in establishment of rhizobial symbiosis. To obtain a holistic view of Medicago truncatula genes e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bda4083bc56f8e6c883b57141020d3
https://doi.org/10.3389/fpls.2016.00794

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