Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Eric S. McCoy"'
Publikováno v:
F1000Research, Vol 12 (2024)
Background The open field assay is used to study anxiety-related traits and anxiolytic drugs in rodents. This assay entails measuring locomotor activity and time spent in the center of a chamber that is maintained at ambient room temperature. However
Externí odkaz:
https://doaj.org/article/e24c445c7f0644bcac26b833d627826a
Publikováno v:
F1000Research, Vol 12 (2024)
Background The open field assay is used to study anxiety-related traits and anxiolytic drugs in rodents. This assay entails measuring locomotor activity and time spent in the center of a chamber that is maintained at ambient room temperature. However
Externí odkaz:
https://doaj.org/article/db345a6ead4e4f31b084e171a49e9555
Autor:
Lei Xing, Jeremy M. Simon, Travis S. Ptacek, Jason J. Yi, Lipin Loo, Hanqian Mao, Justin M. Wolter, Eric S. McCoy, Smita R. Paranjape, Bonnie Taylor-Blake, Mark J. Zylka
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112706- (2023)
Summary: The E3 ubiquitin ligase Ube3a is biallelically expressed in neural progenitors and glial cells, suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental disorders irrespective of parent of origin. Here, we engineered a
Externí odkaz:
https://doaj.org/article/e51c03b71c704840a187f7c84c88daee
Autor:
Lipin Loo, Jeremy M. Simon, Lei Xing, Eric S. McCoy, Jesse K. Niehaus, Jiami Guo, E. S. Anton, Mark J. Zylka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The authors perform single-cell RNA-seq of the mouse neocortex at an embryonic time point and at birth, and identify new and known cell types, and cell relatedness within and across age. These data serve as a resource to understand brain development
Externí odkaz:
https://doaj.org/article/eef916514df749ae928a6eaa25a3d703
Autor:
Brandon L. Pearson, Jeremy M. Simon, Eric S. McCoy, Gabriela Salazar, Giulia Fragola, Mark J. Zylka
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected
Externí odkaz:
https://doaj.org/article/40eab20cb9c14472bd55674dbc22b4f9
Autor:
Eric S. McCoy, Sang Kyoon Park, Rahul P. Patel, Dan F. Ryan, Zachary J. Mullen, Jacob J. Nesbitt, Josh E. Lopez, Bonnie Taylor-Blake, James L. Krantz, Wenxin Hu, Rosanna L. Garris, Lucas V. Lima, Susana G. Sotocinal, Jean-Sebastien Austin, Adam D. Kashlan, Jessica A. Jimenez, Sanya Shah, Abigail K. Trocinski, Kelly A. Vanden, Rami M. Major, Hannah O. Bazick, Morgan R. Klein, Jeffrey S. Mogil, Guorong Wu, Mark J. Zylka
Publikováno v:
The Journal of Pain. 24:35-36
Facial grimaces are now commonly used to quantify spontaneous pain in mice and other mammalian species, but scoring remains subjective and relies on humans with very different levels of proficiency. Here, we developed a Mouse Grimace Scale (MGS) for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed920e85a66890b243ee01bda5e89578
https://doi.org/10.1016/j.jpain.2023.02.113
https://doi.org/10.1016/j.jpain.2023.02.113
Publikováno v:
F1000Research. 12:234
Background: The open field assay is used to study anxiety-related traits and anxiolytic drugs in rodents. This assay entails measuring locomotor activity and time spent in the center of a chamber that is maintained at ambient room temperature. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb0cb9835b217d8c9a50a6d986f971a
https://doi.org/10.12688/f1000research.130474.1
https://doi.org/10.12688/f1000research.130474.1
Autor:
Wenxin Hu, Chih-Wei Liu, Jessica A. Jiménez, Eric S. McCoy, Yun-Chung Hsiao, Weili Lin, Stephanie M. Engel, Kun Lu, Mark J. Zylka
Publikováno v:
Environmental Health Perspectives. 130
Azoxystrobin (AZ) is a broad-spectrum strobilurin fungicide that is used in agriculture and was recently added to mold- and mildew-resistant wallboards. AZ was found to have toxic effects in animals at embryonic stages and was listed as a frontline t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94115ddf1cef36ea0d13ee225678e768
https://doi.org/10.1289/ehp9808
https://doi.org/10.1289/ehp9808
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36355 (2012)
Calcitonin gene-related peptide (CGRPα, encoded by Calca) is a classic marker of nociceptive dorsal root ganglia (DRG) neurons. Despite years of research, it is unclear what stimuli these neurons detect in vitro or in vivo. To facilitate functional
Externí odkaz:
https://doaj.org/article/fd658e4a913046d3948d56860295abd1
Autor:
Megumi Aita, Bonnie Taylor-Blake, Jeremy M. Simon, Mark J. Zylka, Eric S. McCoy, Benjamin D. Philpot
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutation or deletion of the maternalUBE3Aallele. The maternalUBE3Aallele is expressed in nearly all neurons of the brain and spinal cord, whereas the paternalUBE3Aallele is repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392d08c757ebbb940d761378c3dd4a5f
https://europepmc.org/articles/PMC5647775/
https://europepmc.org/articles/PMC5647775/
