Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Eric S. Hayes"'
Publikováno v:
European Journal of Pharmacology. 844:241-252
A series of amino-2-cyclohexyl ester derivatives were studied for their ion channel blocking and antiarrhythmic actions in the rat and a structure-activity analysis was conducted. The compounds are similar in chemical structure except for ionizable a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298155c861846a53a5ee41362571d065
https://doi.org/10.1016/j.ejphar.2018.12.025
https://doi.org/10.1016/j.ejphar.2018.12.025
Publikováno v:
Measurement of Cardiac Function ISBN: 9781003071853
Measurement of Cardiac Function
Measurement of Cardiac Function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90f36d9bbb062a3ec8ab70b6f32f9521
https://doi.org/10.1201/9781003071853-4
https://doi.org/10.1201/9781003071853-4
Autor:
David A. Saint, Richard A. Wall, Bernard A. MacLeod, Michael J A Walker, G. Adaikan, Alan L. Goldin, G.N. Beatch, Eric S. Hayes, Michael K. Pugsley, Shlomo Abraham
Publikováno v:
Biomedicine & Pharmacotherapy. 106:510-522
Background RSD921, the R,R enantiomer of the kappa (k) agonist PD117,302, lacks significant activity on opioid receptors. Methods The pharmacological and toxicological actions were studied with reference to cardiovascular, cardiac, antiarrhythmic, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f17d1cb72e1f9443e909132f37860f
https://doi.org/10.1016/j.biopha.2018.06.157
https://doi.org/10.1016/j.biopha.2018.06.157
Autor:
Diah Iskandriati, Eric S. Hayes, Fitriya Nur Annisa Dewi, Joko Pamungkas, Villiandra Villiandra, Dondin Sajuthi, Sela Septima Mariya, Yasmina Arditi Pramastri, R.P. Agus Lelana, Ligaya Ita Tumbelaka
Publikováno v:
Jurnal Respirologi Indonesia. 38:115-122
Background: Animal models are essential for the development and improvement of novel and effective methods for diagnostic and treatment of human diseases. Cynomolgus monkeys have been used as animal model in asthma studies wherein they exhibited diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73b57de69649bf50d1d09551a12e1e19
https://doi.org/10.36497/jri.v38i2.166
https://doi.org/10.36497/jri.v38i2.166
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss, Pp 427-435 (2019)
Decades of focus on selective ion channel blockade has been dismissed as an effective approach to antiarrhythmic drug development. In that context many older antiarrhythmic drugs lacking ion channel selectivity may serve as tools to explore mixed ion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc613411a52387b544dc0286c6a25119
https://pubmed.ncbi.nlm.nih.gov/30594781
https://pubmed.ncbi.nlm.nih.gov/30594781
Autor:
Fitriya Nur Annisa Dewi, Joko Pamungkas, Uus Saepuloh, Eric S. Hayes, Dondin Sajuthi, Villiandra Villiandra, Diah Iskandriati, Sela Septima Mariya, Yasmina Paramastri
Publikováno v:
Hayati Journal of Biosciences, Vol 26, Iss 3 (2019)
Cynomolgus macaques (Macaca fascicularis) are an established animal model of asthma, which exhibit different responses to allergen exposure that are clinically relevant. The chemokine ligand gene (CCL7) encodes Monocyte Chemotactic Protein-3, which h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3cc223cc4762a03c11e0896abb3611
https://doi.org/10.4308/hjb.26.3.129
https://doi.org/10.4308/hjb.26.3.129
Publikováno v:
Pharmacological Research. 97:64-69
This study characterized the antiarrhythmic effects of the opioid receptor antagonist naloxone in rats subject to electrically induced and ischemic arrhythmias. Naloxone (2, 8 and 32 μmol/kg/min) was examined on heart rate, blood pressure, and the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395e380b08cc8b72940f866f26bcd3c4
https://doi.org/10.1016/j.phrs.2015.04.011
https://doi.org/10.1016/j.phrs.2015.04.011
Autor:
Eric S. Hayes, Michael K. Pugsley, Simon Authier, Michael V. Accardi, Robert L. Hamlin, Michael J. Curtis
Publikováno v:
Journal of pharmacological and toxicological methods. 81
Safety pharmacology (SP) has evolved in terms of architecture and content since the inception of the SP Society (SPS). SP was initially focused on the issue of drug-induced QT prolongation, but has now become a broad spectrum discipline with expandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e31fd5aadb32800f440d15bd18d1fb
https://pubmed.ncbi.nlm.nih.gov/27343819
https://pubmed.ncbi.nlm.nih.gov/27343819
Publikováno v:
Handbook of experimental pharmacology. 229
Cardiac safety pharmacology is a continuously evolving discipline that uses the basic principles of pharmacology in a regulatory-driven process to generate data to inform risk/benefit assessment of a new chemical entity (NCE). The aim of cardiac safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec6117acf75925469f866cbd2e9c6f94
https://pubmed.ncbi.nlm.nih.gov/26091640
https://pubmed.ncbi.nlm.nih.gov/26091640
Publikováno v:
European journal of pharmacology. 761
These studies examined the opioid and non-opioid in vivo and in vitro actions of PD117,302 (((±)-trans-N-methyl-N-[2-(l-pyrrolidinyl)-cyclohexyl]benzo[b]thiophene-4-acetamide), a kappa (κ)-opioid receptor agonist. PD117,302 selectively labeled the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e458e72e87a7ad2f407e62bde8520f2
https://pubmed.ncbi.nlm.nih.gov/26086860
https://pubmed.ncbi.nlm.nih.gov/26086860