Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Eric S. Geanes"'
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-10 (2024)
Abstract Background Increased inflammation caused by SARS-CoV-2 infection can lead to severe coronavirus disease 2019 (COVID-19) and long-term disease manifestations. The mechanisms of this variable long-term immune activation are poorly defined. One
Externí odkaz:
https://doaj.org/article/1b4881bd68094972a8a309a94266d9f0
Autor:
Eric S. Geanes, Rebecca McLennan, Stephen H. Pierce, Heather L. Menden, Oishi Paul, Venkatesh Sampath, Todd Bradley
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109975- (2024)
Summary: Severe COVID-19 often leads to secondary infections and sepsis that contribute to long hospital stays and mortality. However, our understanding of the precise immune mechanisms driving severe complications after SARS-CoV-2 infection remains
Externí odkaz:
https://doaj.org/article/66359978581b4fd894b7c2cfb051929c
Autor:
Cas LeMaster, Stephen H. Pierce, Eric S. Geanes, Santosh Khanal, Staci S. Elliott, Allison B. Scott, Daniel A. Louiselle, Rebecca McLennan, Devika Maulik, Tamorah Lewis, Tomi Pastinen, Todd Bradley
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Human milk is essential for infant nutrition and immunity, providing protection against infections and other immune-mediated diseases during the lactation period and beyond in later childhood. Milk contains a broad range of bioactive factors
Externí odkaz:
https://doaj.org/article/c54960105c8d48d4a967098069dc9f3c
Autor:
Eric S. Geanes, Cas LeMaster, Elizabeth R. Fraley, Santosh Khanal, Rebecca McLennan, Elin Grundberg, Rangaraj Selvarangan, Todd Bradley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract SARS-CoV-2 is a novel betacoronavirus that caused coronavirus disease 2019 and has resulted in millions of deaths worldwide. Novel coronavirus infections in humans have steadily become more common. Understanding antibody responses to SARS-Co
Externí odkaz:
https://doaj.org/article/c702567c959b4f8f930048baf979b985
Autor:
Eric S. Geanes, Stacey A. Krepel, Rebecca McLennan, Stephen Pierce, Santosh Khanal, Todd Bradley
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma, is typically treated with chemotherapy combined with the immunotherapy rituximab, an antibody targeting the B cell receptor, CD20. Despite the success of this treatment regimen,
Externí odkaz:
https://doaj.org/article/10008d2ecdca42efad47ee1176346b74
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Natural killer (NK) cells are critical for targeting and killing tumor, virus-infected and stressed cells as a member of the innate immune system. Recently, NK cells have also emerged as key regulators of adaptive immunity and have become a prominent
Externí odkaz:
https://doaj.org/article/249a7eb35bcd420699dbc67af39a34d3
Publikováno v:
The Journal of Infectious Diseases. 226:1712-1716
The SARS-CoV-2 Omicron variant has caused infections among individuals vaccinated or with prior COVID-19, suggesting immune escape. Here, we showed a decrease in binding and surrogate neutralizing antibody responses to the Omicron variant after 2 dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65f1394ef2ff8e1edebd10eb5d70181
https://doi.org/10.1093/infdis/jiac247
https://doi.org/10.1093/infdis/jiac247
Autor:
Joan Lewis-Wambi, Christy R. Hagan, Ossama Tawfik, Katherine R. Walter, Eric S. Geanes, Asona J. Lui, Taylor E. Escher
S1. E2 and GO-201 decrease IFITM1 expression. S2. Combination treatment with JAK/STAT inhibitor. S3. Alterations to IFITM1 expression upon MUC1 knockdown and Rux treatment. S4. Estrogen treatment reduces tumor size in Nude mice injected with MCF-7:5C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9353866a373f95b54e7722514cbcca1
https://doi.org/10.1158/1541-7786.22512468.v1
https://doi.org/10.1158/1541-7786.22512468.v1
Autor:
Joan Lewis-Wambi, Christy R. Hagan, Ossama Tawfik, Katherine R. Walter, Eric S. Geanes, Asona J. Lui, Taylor E. Escher
The human oncoprotein, mucin 1 (MUC1), drives tumorigenesis in breast carcinomas by promoting epithelial-to-mesenchymal transition (EMT), epigenetic reprogramming, and evasion of immune response. MUC1 interacts with STAT1, through JAK/STAT signaling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a989f1c292dc7a8a06dc9b7efcafb3b0
https://doi.org/10.1158/1541-7786.c.6540249.v1
https://doi.org/10.1158/1541-7786.c.6540249.v1
Autor:
Eric S. Geanes, Sean M. Holloran, Anuradha Roy, Olivia K. Provance, Sumedha Gunewardena, Christy R. Hagan, Scott Weir, Asona Lui, Joan Lewis-Wambi
Publikováno v:
Cancer Lett
Overexpression of interferon induced transmembrane protein-1 (IFITM1) enhances tumor progression in multiple cancers, but its role in triple-negative breast cancer (TNBC) is unknown. Here, we explore the functional significance and regulation of IFIT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96aeadd83c2e633eef553e643090dba
https://doi.org/10.1016/j.canlet.2021.05.006
https://doi.org/10.1016/j.canlet.2021.05.006